Search Results

You are looking at 1 - 10 of 45 items for :

  • "thyroid nodule" x
Clear All
Open access

Yun Hu, Na Li, Peng Jiang, Liang Cheng, Bo Ding, Xiao-Mei Liu, Ke He, Yun-Qing Zhu, Bing-li Liu, Xin Cao, Hong Zhou and Xiao-Ming Mao

Introduction Thyroid nodules are very common; up to 65% of the general population have at least one thyroid nodule ( 1 ), but most of them have no symptoms, and life expectancy is not affected ( 2 ). Recent studies have focused mainly on the

Open access

Helle Døssing, Finn Noe Bennedbæk and Laszlo Hegedüs

Introduction Thyroid nodules are common in the adult population and according to several studies 15–30% of thyroid nodules are cystic or predominantly cystic ( 1 ). The incidence of thyroid cancer in cystic nodules is low and comparable or

Open access

Barbora Pekova, Sarka Dvorakova, Vlasta Sykorova, Gabriela Vacinova, Eliska Vaclavikova, Jitka Moravcova, Rami Katra, Petr Vlcek, Pavla Sykorova, Daniela Kodetova, Josef Vcelak and Bela Bendlova

Introduction Thyroid nodules affect around 1% of the pediatric population. The incidence has been steadily increasing over the last decades, by approximately 1.1% per year worldwide ( 1 , 2 ). Possible reasons for this increase are

Open access

Giorgio Grani, Livia Lamartina, Vito Cantisani, Marianna Maranghi, Piernatale Lucia and Cosimo Durante

Introduction Thyroid nodules are an increasingly common finding during imaging examinations of the neck, but only a small proportion of these lesions ultimately prove to be malignant ( 1 ). Fine-needle aspiration (FNA) biopsy plays a major

Open access

Kristine Zøylner Swan, Steen Joop Bonnema, Marie Louise Jespersen and Viveque Egsgaard Nielsen

ultrasonography (US) and fine-needle aspiration biopsy (FNAB) are very useful in the evaluation of thyroid nodules, the identification of malignancy remains a challenge. Several US characteristics have been found to be more prevalent in malignant compared with

Open access

Anello Marcello Poma, Riccardo Giannini, Paolo Piaggi, Clara Ugolini, Gabriele Materazzi, Paolo Miccoli, Paolo Vitti and Fulvio Basolo

Sawka AM Schlumberger M 2015 American Thyroid Association Management Guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: the American Thyroid Association Guidelines task force on thyroid nodules and

Open access

Adriano N Cury, Verônica T Meira, Osmar Monte, Marília Marone, Nilza M Scalissi, Cristiane Kochi, Luís E P Calliari and Carlos A Longui

I, such as thyroid carcinoma and gonadal and hematological abnormalities, were observed. One patient was diagnosed with a thyroid nodule during a long follow-up, but a cytological analysis confirmed a benign subtype (adenoma). Discussion RAI

Open access

Marco Marino, Valentina Cirello, Valentina Gnarini, Carla Colombo, Elisa Pignatti, Livio Casarini, Chiara Diazzi, Vincenzo Rochira, Katia Cioni, Bruno Madeo, Cesare Carani, Manuela Simoni and Laura Fugazzola

Papillary thyroid carcinoma (PTC) is the most common endocrine malignancy, with a steadily increasing incidence in the last few decades worldwide. The predisposition to developing this carcinoma by the heterozygous state of rs2910164 within the precursor of the miR-146a has been reported, but recently not confirmed. Interestingly, on the same chromosome, almost 50 kb separate the pre-miR-146a from the pituitary tumor-transforming gene 1 (PTTG1), a proto-oncogene involved in several tumors, including thyroid cancers. In this study, we analyzed, using a case–control design, the genetic association between PTC and the genomic region encompassing pre-miR-146a rs2910164 and PTTG1 rs1862391 and rs2910202. We enrolled 307 affected patients and 206 healthy controls. The possible presence of thyroid nodules in controls was excluded by ultrasonography. All the cases were submitted to single-nucleotide polymorphism (SNP) genotyping of pre-miR-146a and PTTG1, and risk association analyses were carried out. The genotypic and allelic frequencies of pre-miR-146a rs2910164 were not statistically different in the patients and controls, and this SNP was not in linkage disequilibrium with the investigated PTTG1 SNPs. Consistently, meta-analyses, the first including all the affected cases published to date, did not confirm the previously reported association of the heterozygous CG genotype with PTC. The PTTG1 SNPs exhibited the same allelic frequency in the patients and controls and were not associated with the disease. In conclusion, in a well-selected Italian population, neither pre-miR-146a rs2910164 nor PTTG1 rs1862391 and rs2910202 were found to be associated with the risk of developing PTC.

Open access

Bekir Cakir, F Neslihan Cuhaci Seyrek, Oya Topaloglu, Didem Ozdemir, Ahmet Dirikoc, Cevdet Aydin, Sefika Burcak Polat, Berna Evranos Ogmen, Ali Abbas Tam, Husniye Baser, Aylin Kilic Yazgan, Mehmet Kilic, Afra Alkan and Reyhan Ersoy

lesions, such as cervical lymph nodes and thyroid nodules, may occasionally remain difficult ( 7 , 13 ). Ultrasound elastography (USE) is a non-invasive and dynamic technique that objectively evaluates tissue hardness by measuring tissue elasticity ( 14

Open access

Philippe Thuillier, Nathalie Roudaut, Geneviève Crouzeix, Marie Cavarec, Philippe Robin, Ronan Abgral, Véronique Kerlan and Pierre-Yves Salaun

eventual thyroiditis were reported. Thyroid nodules were characterized according to the usual criteria (dimensions, echogenicity, echostructure, margins, presence or absence of macrocalcifiations, microcalcifications and type of vascularization: absent