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Jia Liu, Min Liu, Zhe Chen, Yumei Jia and Guang Wang

-mapping value along with the increased severity of thyroid dysfunction (among the control group, the EU group, the SHO group and the HO group) ( P  < 0.01; Figs 1 , 2 and Table 1 ). Figure 1 Color maps of thyroid T1-mapping based on a modified

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Xiujuan Su, Yan Zhao, Zhijuan Cao, Yingying Yang, Tony Duan and Jing Hua

disease varies widely in its subtypes and populations ( 6 , 7 ). A systematic review reported that pooled prevalence of thyroid dysfunction, using the 97.5th percentile as an upper limit for TSH, ranges from 0.5 to 3.5% in different subtypes ( 8

Open access

Paolo G Arduino, Dora Karimi, Federico Tirone, Veronica Sciannameo, Fulvio Ricceri, Marco Cabras, Alessio Gambino, Davide Conrotto, Stefano Salzano, Mario Carbone and Roberto Broccoletti

, hypertension, and HCV infection. Discussion To the best of our knowledge, this is the largest prospective study ever published reporting the possible positive relationship between OLP and thyroid diseases. The prevalence of thyroid dysfunction

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Nese Cinar and Alper Gurlek

ADP, vaspin, and visfatin in the context of thyroid dysfunction and the associated changes in adipose tissue and insulin resistance. The reason for choosing them is the increasing evidence regarding their changes in states of thyroid dysfunction

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L E Zijlstra, D M van Velzen, S Simsek, S P Mooijaart, M van Buren, D J Stott, I Ford, J W Jukema and S Trompet

conflicting results from large observational studies. Therefore, the aim of this study is to investigate whether kidney function modifies the association of subclinical thyroid dysfunction and the risk of cardiovascular outcomes in older patients

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Jakob Kirkegård, Dora Körmendiné Farkas, Jens Otto Lunde Jørgensen and Deirdre P Cronin-Fenton

disease. Some gastrointestinal cancers may also present with symptoms mimicking thyroid dysfunction such as fatigue, fever, gastrointestinal symptoms and weight loss. This could lead to an early cancer diagnosis, increasing the SIRs in the first year of

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Jiashu Li, Aihua Liu, Haixia Liu, Chenyan Li, Weiwei Wang, Cheng Han, Xinyi Wang, Yuanyuan Zhang, Weiping Teng and Zhongyan Shan

Introduction Thyroid dysfunction is a common endocrine disorder among reproductively aged women ( 1 ), with a morbidity of 2–3%. Subclinical hypothyroidism (SCH) is the most common condition of thyroid disorders during pregnancy ( 2 ) and is

Open access

J Brossaud, V Pallet and J-B Corcuff

Vitamin A (retinol) is a micronutrient critical for cell proliferation and differentiation. In adults, vitamin A and metabolites such as retinoic acid (RA) play major roles in vision, immune and brain functions and tissue remodelling and metabolism. This review presents the physiological interactions of retinoids and endocrine tissues and hormonal systems. Two endocrine systems have been particularly studied. In the pituitary, retinoids target the corticotrophs with a possible therapeutic use in corticotropinomas. In the thyroid, retinoids interfere with iodine metabolism and vitamin A deficiency aggravates thyroid dysfunction caused by iodine-deficient diets. Retinoids use in thyroid cancer appears less promising than expected. Recent and still controversial studies investigated the relations between retinoids and metabolic syndrome. Indeed, retinoids contribute to pancreatic development and modify fat and glucose metabolism. However, more detailed studies are needed before planning any therapeutic use. Finally, retinoids probably play more minor roles in adrenal and gonads development and function apart from their major effects on spermatogenesis.

Open access

Aleksandra Krygier, Ewelina Szczepanek-Parulska, Dorota Filipowicz and Marek Ruchala

Introduction: Hepcidin is an acute-phase protein and a key regulator of iron homeostasis. Anaemia frequently occurs in patients with thyroid dysfunction, and hepcidin may be a potential link.

Objectives: Prospective assessment of hepcidin serum concentration and other parameters related to Fe homeostasis in hyperthyroid patients in the course of GD at diagnosis and during remission.

Patients and Methods: Out of 70 patients recruited, 42 (32 women, 10 men), aged 42.5±15.1 years, met the inclusion criteria. Clinical and biochemical assessment, including hepcidin measurement by ELISA, was performed at baseline (T0) and after restoration of euthyroidism (T1).

Results: Hepcidin concentration at T0 in the 24 patients who completed the study was significantly higher than the value during euthyroidism (28.7 (8.1-39.4) ng/mL vs. 7.9 (4.3-12.9) ng/mL, p<0.001). Hepcidin level was most significantly correlated with ferritin (rho = 0.723) in women at T0. In both men (377 (171-411) vs. 165 (84-237) ng/mL, p=0.001) and women (84 (23-104) vs. 35 (16-64) ng/mL, p=0.001), a significant decrease in ferritin level was demonstrated following therapy. A significant (p<0.001) increase in mean corpuscular volume (MCV) (83.5 (82.5-87.1) vs. 89.5 (88.8-90.0) fL) and mean concentration of haemoglobin (MCH) (29.0 (28.0-29.4) vs. 30.4 (29.5-31.1) pg) was observed.

Conclusions: Hepcidin and ferritin decrease significantly during the transition from a hyperthyroid state to euthyroidism in patients with GD. The observed changes occur in parallel to iron homeostasis fluctuations. During the transition from the hyperthyroid state to euthyroidism, the improvement of haematological status is reflected mainly by the increase in MCV and MCH.

Open access

Amir Bashkin, Eliran Yaakobi, Marina Nodelman and Ohad Ronen

Introduction Routine TSH blood level screening test for thyroid function in hospitalized patients with other acute disease is not recommended by the leading associations of thyroid medicine ( 1 , 2 , 3 , 4 ). Thyroid dysfunction during