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Joanna Klubo-Gwiezdzinska, John Costello Jr, Kirk Jensen, Aneeta Patel, Rok Tkavc, Douglas Van Nostrand, Kenneth D Burman, Leonard Wartofsky and Vasyl Vasko

Introduction Standard treatment of thyroid cancer consists of surgical resection and radioiodine ( 131 I) therapy ( 1 ). Depending on the risk stratification of the individual patient, the primary goal of the application of radioactive iodine

Open access

Zeming Liu, Di Hu, Yihui Huang, Sichao Chen, Wen Zeng, Ling Zhou, Wei Zhou, Min Wang, Haifeng Feng, Wei Wei, Chao Zhang, Danyang Chen and Liang Guo

carcinoma. Among pediatric patients, papillary thyroid carcinoma and follicular thyroid cancer account for more than 90% ( 2 ) of all childhood cases. However, medulary thyroid cancer, poorly differentiated tumors and undifferentiated (anaplastic) thyroid

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M L Gild, M Bullock, C K Pon, B G Robinson and R J Clifton-Bligh

including prostate (9) , non small cell lung cancer (10) , and osteosarcoma (11) . With regard to thyroid cancer, early studies have yielded data that supports the potential clinical utility of targeting HSP90 to treat this disease. 17-AAG has showed an

Open access

Joana Simões-Pereira, Daniel Macedo and Maria João Bugalho

Introduction Thyroid cancer usually has a favorable prognosis with a reported 10-year survival for differentiated and medullary thyroid carcinoma of approximately 80–95% ( 1 ) and 68–85% ( 2 , 3 ), respectively. Distant metastases occur in a

Open access

Mabel E Bohórquez, Ana P Estrada, Jacob Stultz, Ruta Sahasrabudhe, John Williamson, Paul Lott, Carlos S Duque, Jorge Donado, Gilbert Mateus, Fernando Bolaños, Alejandro Vélez, Magdalena Echeverry and Luis G Carvajal-Carmona

Introduction Thyroid cancer (TC) is becoming epidemic, growing in incidence both nationally and internationally ( 1 ). Nonmedullary thyroid cancer (NMTC) makes up over 95% of all cases, making it the most common endocrine malignancy ( 2

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Norra Kwong, Ellen Marqusee, Michael S Gordon, P Reed Larsen, Jeffrey R Garber, Matthew I Kim and Erik K Alexander

Introduction Well-differentiated thyroid cancer is common, easily identified, and often curable. While the incidence of thyroid cancer has nearly tripled in the past three decades, mortality rates have remained stable (1, 2, 3) . This underscores

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Ashley N Reeb, Andrea Ziegler and Reigh-Yi Lin

Introduction Follicular thyroid cancer (FTC) is the second most frequently diagnosed thyroid cancer after papillary thyroid cancer (PTC). About 10,000 cases of FTC are diagnosed annually in the United States, comprising about 10–15% of all

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Susana Pastor, Abdelmounaim Akdi, Eddy R González, Juan Castell, Josefina Biarnés, Ricard Marcos and Antonia Velázquez

Introduction Thyroid cancer is of special concern in endocrinology practice, accounting for more than 90% of all endocrine cancers. Moreover, its incidence is increasing in developed countries (1, 2) . Differentiated thyroid carcinoma (DTC

Open access

Andrea Mazurat, Andrea Torroni, Jane Hendrickson-Rebizant, Harbinder Benning, Richard W Nason and K Alok Pathak

Introduction Well-differentiated thyroid carcinoma (WDTC) represents a group of thyroid cancers that are associated with increasing incidence and excellent posttreatment outcome (1) . This group comprises different histological types, the most

Open access

Erika Urbano Lima, Ileana G S Rubio, Joaquim Custodio Da Silva, Ana Luiza Galrão, Danielle Pêssoa, Taise Cerqueira Oliveira, Fabiane Carrijo, Igor Silva Campos, Luciano Fonseca Espinheira, Luiz Jose Sampaio, Claudio Rogerio Lima, Janete Maria Cerutti and Helton Estrela Ramos

Introduction Differentiated thyroid cancer (DTC) has continued to increase over the past several decades, likely due to enhanced detection ( 1 , 2 ). Cancer research, in general, has benefited greatly from many of the new scientific