testosterone-dependent group are transgender people looking for masculinization. These people are birth-assigned female but identify as male or non-binary. To induce virilization, testosterone therapy is prescribed. This includes deepening of the voice
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Milou Cecilia Madsen, Martin den Heijer, Claudia Pees, Nienke R Biermasz, and Leontine E H Bakker
Mette Bøgehave, Dorte Glintborg, Jørgen Brodersen Gram, Else-Marie Bladbjerg, Marianne Skovsager Andersen, and Johannes Jakobsen Sidelmann
significantly different from the placebo group. Corresponding to our findings, previous studies report a reduction in protein C ( 23 ), an increase in free protein S ( 26 ), and no effect on TFPI and antithrombin ( 20 , 22 ) after testosterone therapy. The
Sakina Kherra, Wendy Forsyth Paterson, Filiz Mine Cizmecioglu, Jeremy Huw Jones, Mariam Kourime, Heba Hassan Elsedfy, Sameh Tawfik, Andreas Kyriakou, Mohamad Guftar Shaikh, and Malcolm David Cairns Donaldson
point per patient per age band. Median (range) values are shown. Testosterone values post hCG given to 16/19 patients prior to surgery and to 9 patients to test Leydig cell reserve are shown. Data does not include patients on testosterone therapy
Hans Valdemar López Krabbe, Jørgen Holm Petersen, Louise Laub Asserhøj, Trine Holm Johannsen, Peter Christiansen, Rikke Beck Jensen, Line Hartvig Cleemann, Casper P. Hagen, Lærke Priskorn, Niels Jørgensen, Katharina M Main, Anders Juul, and Lise Aksglaede
Adult patients with Klinefelter syndrome (KS) are characterized by a highly variable phenotype including tall stature, obesity and hypergonadotropic hypogonadism as well as an increased risk of developing insulin resistance, metabolic syndrome, and osteoporosis. Most adults need testosterone replacement therapy (TRT), whereas the use of TRT during puberty has been debated. In this retrospective, observational study reproductive hormones and whole-body dual-energy X-ray absorptiometry (DXA) derived body composition and bone mineral content were standardized to age-related standard deviation scores (SDS) in 62 patients with KS aged 5.9 to 20.6 years. Serum concentrations of total testosterone and inhibin B were low, whereas LH and FSH were high in patients before TRT. Despite normal body mass index (BMI), body fat% and ratio between android fat% and gynoid fat% were significantly higher in the entire group irrespective of treatment status. In patients evaluated before and during TRT a tendency towards a more beneficial body composition with a significant reduction in ratio between android fat% and gynoid fat% during TRT was found. Bone mineral content (BMC) did not differ from the reference, but BMC corrected for bone area was significantly lower when compared to the reference. This study confirms that patients with KS have an unfavorable body composition and an impaired bone mineral status already during childhood and adolescence. Systematic studies are needed to evaluate whether TRT during puberty will improve these parameters.
Sebastian Franik, Kathrin Fleischer, Barbara Kortmann, Nike M Stikkelbroeck, Kathleen D’Hauwers, Claire Bouvattier, Jolanta Slowikowska-Hilczer, Solange Grunenwald, Tim van de Grift, Audrey Cartault, Annette Richter-Unruh, Nicole Reisch, Ute Thyen, Joanna IntHout, Hedi L Claahsen-van der Grinten, and
engagement, age of diagnosis, testosterone therapy and physical and mental health status, and to compare values to a European Social Surveys (ESS) reference population. Methods Study population This study was part of the European dsd-LIFE study, a
Mikkel Andreassen, Anders Juul, Ulla Feldt-Rasmussen, and Niels Jørgensen
with pituitary diseases were offered cryopreservation of semen for future fertility treatment before testosterone therapy was initiated, or in selected younger cases before pituitary surgery or radiation therapy. All patients who started testosterone
Agnieszka Pazderska, Yaasir Mamoojee, Satish Artham, Margaret Miller, Stephen G Ball, Tim Cheetham, and Richard Quinton
remainder being identifiable later during the process of pubertal induction through failure to normalise testicular volume with testosterone therapy ( 1 ). Given the aforementioned factors, the diagnostic evaluation and management of pubertal delay should
Jennifer K Y Ko, Thomas F J King, Louise Williams, Sarah M Creighton, and Gerard S Conway
are gradually being phased out because of the increased risk of thrombosis ( 4 ). Oestradiol implants are not widely available in the United Kingdom. Commonly available option for testosterone therapy in the United Kingdom includes 2% transdermal gel
Qiu-ming Yao, Bin Wang, Xiao-fei An, Jin-an Zhang, and Liumei Ding
study by Canguven and coworkers found that testosterone therapy could decrease the levels of glycated hemoglobin, total cholesterol and triglycerides in elderly hypogonadal men, which might reduce the risk of diabetes in those individuals ( 62 ). It is
M Jensterle, A Podbregar, K Goricar, N Gregoric, and A Janez
testosterone therapy in obese men with severe obstructive sleep apnoea: a randomised placebo-controlled trial . European Journal of Endocrinology 2012 167 531 – 541 . ( https://doi.org/10.1530/EJE-12-0525 ) 10.1530/EJE-12-0525 22848006 6 Ng Tang Fui M
