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Andrea Mazurat, Andrea Torroni, Jane Hendrickson-Rebizant, Harbinder Benning, Richard W Nason and K Alok Pathak

stratification. Several studies have shown that the relationship between the age at diagnosis and the disease-specific survival (DSS) of WDTC is inversely proportional and is better represented by an exponential function, suggesting that age should preferably be

Open access

Norra Kwong, Ellen Marqusee, Michael S Gordon, P Reed Larsen, Jeffrey R Garber, Matthew I Kim and Erik K Alexander

their guarded prognosis. The 10-year survival rate for patients with distant metastatic thyroid cancer ranges from 26 to 60% (21, 22, 23) . As a result, more aggressive and repeated therapies are often employed. For instance, most patients with

Open access

Filomena Cetani, Chiara Banti, Elena Pardi, Simona Borsari, Paolo Viacava, Paolo Miccoli, Liborio Torregrossa, Fulvio Basolo, Maria Rosa Pelizzo, Massimo Rugge, Gianmaria Pennelli, Guido Gasparri, Mauro Papotti, Marco Volante, Edda Vignali, Federica Saponaro and Claudio Marcocci

test, or Fisher test, as appropriate. Differences in the overall survival (time to death of the disease) among patient groups were evaluated by the Kaplan–Meier method, and P values were calculated by the log-rank test. A P value of <0.05 was

Open access

Ashley K Clift, Omar Faiz, Robert Goldin, John Martin, Harpreet Wasan, Marc-Olaf Liedke, Erik Schloericke, Anna Malczewska, Guido Rindi, Mark Kidd, Irvin M Modlin and Andrea Frilling

/UICC) staging and grading system ( 16 ). Although these have been shown to correlate with survival in large cohorts of patients ( 17 , 18 ), precise prognostication and definition of management strategies for individual patients remain elusive. Significant

Open access

Huy Gia Vuong, Uyen N P Duong, Ahmed M A Altibi, Hanh T T Ngo, Thong Quang Pham, Hung Minh Tran, Greta Gandolfi and Lewis Hassell

, 35 articles with a total of 17,732 PTC patients were included for final analysis ( Fig. 1 ). Figure 1 Study flowchart. DFS, disease-free survival; DSS, disease-specific survival; HR, hazard ratio; KMC, Kaplan Meier curve; VHL, Virtual Health

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Ishita Gupta, Allal Ouhtit, Adil Al-Ajmi, Syed Gauhar A Rizvi, Hamad Al-Riyami, Marwa Al-Riyami and Yahya Tamimi

polymorphisms and breast cancer disease. Kaplan–Meier method was used for survival analysis and significant differences between gene expression and overall survival was compared using the log-rank test. Based on a previous study ( 6 ), breast cancer patients

Open access

T Szarvas, B Jardin-Watelet, N Bourgoin, M J Hoffmann, P Nyirády, C Oláh, T Széll, A Csizmarik, B Hadaschik and H Reis

of the patients received neoadjuvant chemotherapy prior to surgery. Clinical data including age, gender, tumor stage, grade, lymph node (LN) status, presence of distant metastasis and details on survival were obtained from the medical records and

Open access

Huy Gia Vuong, Nguyen Phuoc Long, Nguyen Hoang Anh, Tran Diem Nghi, Mai Van Hieu, Le Phi Hung, Tadao Nakazawa, Ryohei Katoh and Tetsuo Kondo

There are still ongoing debates as to which cut-off percentage of tall cell (TC) should be used to define tall cell variant (TCV) papillary thyroid carcinoma (PTC). In this meta-analysis, we aimed to investigate the clinicopathological significance of PTC with tall cell features (PTC-TCF, PTC with 10–50% of TCs) in comparison with classical PTC and TCVPTC (PTC with more than 50% of TCs) to clarify the controversial issue. Four electronic databases including PubMed, Web of Science, Scopus and Virtual Health Library were accessed to search for relevant articles. We extracted data from published studies and pooled into odds ratio (OR) and its corresponding 95% confidence intervals (CIs) using random-effect modeling. Nine studies comprising 403 TCVPTCs, 325 PTC-TCFs and 3552 classical PTCs were included for meta-analyses. Overall, the clinicopathological profiles of PTC-TCF including multifocality, extrathyroidal extension, lymph node metastasis, distant metastasis and patient mortality were not statistically different from those of TCVPTC. Additionally, PTC-TCF and TCVPTC were both associated with an increased risk for aggressive clinical courses as compared to classical PTC. The prevalence of BRAF mutation in PTC-TCF and TCVPTC was comparable and both were significantly higher than that in classical PTC. The present meta-analysis demonstrated that even a PTC comprising only 10% of TCs might be associated with a poor clinical outcome. Therefore, the proportions of PTC in PTC should be carefully estimated and reported even when the TC component is as little as 10%.

Open access

Jes Sloth Mathiesen, Jens Peter Kroustrup, Peter Vestergaard, Per Løgstrup Poulsen, Åse Krogh Rasmussen, Ulla Feldt-Rasmussen, Sten Schytte, Stefano Christian Londero, Henrik Baymler Pedersen, Christoffer Holst Hahn, Jens Bentzen, Sören Möller, Mette Gaustadnes, Maria Rossing, Finn Cilius Nielsen, Kim Brixen, Christian Godballe and Danish Thyroid Cancer Group (DATHYRCA)

. Consequently, we conducted the first population-based study aiming to evaluate if the recently proposed TNM groupings provide better survival discrimination than the current AJCC TNM staging system in a nationwide MTC cohort outside the United States

Open access

Chao-bin He, Yu Zhang, Zhi-yuan Cai and Xiao-jun Lin

adenocarcinoma, the primary source of mortality of metastatic PNETs is mainly the dysfunction of metastatic organs, such as liver failure ( 6 ). Although the presence of distant metastasis is correlated with shortened long-term survival, the appropriately