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Andrea Mazurat, Andrea Torroni, Jane Hendrickson-Rebizant, Harbinder Benning, Richard W Nason and K Alok Pathak

stratification. Several studies have shown that the relationship between the age at diagnosis and the disease-specific survival (DSS) of WDTC is inversely proportional and is better represented by an exponential function, suggesting that age should preferably be

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Norra Kwong, Ellen Marqusee, Michael S Gordon, P Reed Larsen, Jeffrey R Garber, Matthew I Kim and Erik K Alexander

their guarded prognosis. The 10-year survival rate for patients with distant metastatic thyroid cancer ranges from 26 to 60% (21, 22, 23) . As a result, more aggressive and repeated therapies are often employed. For instance, most patients with

Open access

Filomena Cetani, Chiara Banti, Elena Pardi, Simona Borsari, Paolo Viacava, Paolo Miccoli, Liborio Torregrossa, Fulvio Basolo, Maria Rosa Pelizzo, Massimo Rugge, Gianmaria Pennelli, Guido Gasparri, Mauro Papotti, Marco Volante, Edda Vignali, Federica Saponaro and Claudio Marcocci

test, or Fisher test, as appropriate. Differences in the overall survival (time to death of the disease) among patient groups were evaluated by the Kaplan–Meier method, and P values were calculated by the log-rank test. A P value of <0.05 was

Open access

Marra Jai Aghajani, Tara Laurine Roberts, Tao Yang, Charles Eugenio McCafferty, Nicole J Caixeiro, Paul DeSouza and Navin Niles

become refractory to RAI, which is associated with a 10-year survival rate of only 10% ( 4 , 5 ). As mortality rates remain high for patients with advanced or metastatic DTC, continued research exploring novel molecular-based biomarkers that can enhance

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K G Samsom, L M van Veenendaal, G D Valk, M R Vriens, M E T Tesselaar and J G van den Berg

patients with sporadic SI-NETs, the determinant of genetic or epigenetic alterations and the outcomes of prognosis, survival or progression. Synonyms of SI-NETs and (epi)genetic alterations with the outcome described as prognosis, survival and progression

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Ashley K Clift, Omar Faiz, Robert Goldin, John Martin, Harpreet Wasan, Marc-Olaf Liedke, Erik Schloericke, Anna Malczewska, Guido Rindi, Mark Kidd, Irvin M Modlin and Andrea Frilling

/UICC) staging and grading system ( 16 ). Although these have been shown to correlate with survival in large cohorts of patients ( 17 , 18 ), precise prognostication and definition of management strategies for individual patients remain elusive. Significant

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Ishita Gupta, Allal Ouhtit, Adil Al-Ajmi, Syed Gauhar A Rizvi, Hamad Al-Riyami, Marwa Al-Riyami and Yahya Tamimi

polymorphisms and breast cancer disease. Kaplan–Meier method was used for survival analysis and significant differences between gene expression and overall survival was compared using the log-rank test. Based on a previous study ( 6 ), breast cancer patients

Open access

Huy Gia Vuong, Uyen N P Duong, Ahmed M A Altibi, Hanh T T Ngo, Thong Quang Pham, Hung Minh Tran, Greta Gandolfi and Lewis Hassell

, 35 articles with a total of 17,732 PTC patients were included for final analysis ( Fig. 1 ). Figure 1 Study flowchart. DFS, disease-free survival; DSS, disease-specific survival; HR, hazard ratio; KMC, Kaplan Meier curve; VHL, Virtual Health

Open access

T Szarvas, B Jardin-Watelet, N Bourgoin, M J Hoffmann, P Nyirády, C Oláh, T Széll, A Csizmarik, B Hadaschik and H Reis

of the patients received neoadjuvant chemotherapy prior to surgery. Clinical data including age, gender, tumor stage, grade, lymph node (LN) status, presence of distant metastasis and details on survival were obtained from the medical records and

Open access

Dong Cen, Hui Liu, Zhe Wan, Zhongjie Lin, Yanting Wang, Junjie Xu and Yuelong Liang

Purpose: Gallbladder neuroendocrine neoplasm (GB-NEN) is a relatively rare neoplasm, accounting for 0.5% of all neuroendocrine neoplasm cases and 2.1% of gallbladder cancers. Because of the limited understanding of GB-NEN, the aim of this study was to explore the clinicopathology and survival of GB-NEN patients selected from the Surveillance, Epidemiology, and End Results (SEER) database.

Methods: A total of 248 GB-NEN patients from the SEER database diagnosed between 2004 and 2015 were included. Kaplan–Meier curves were used to examine survival outcomes. Multivariate Cox proportional hazard models were used to estimate hazard ratios with 95% confidence intervals to analyze the impact of factors on overall survival and cancer-specific survival.

Results: The majority of the GB-NEN patients were women (67.3%), white (77%), and married (61.7%). Most tumors were <2 cm in size (31.0%), G3 stage (25.8%), and distant SEER stage (41.1%). Lots of cases showed an absence of lymph node metastasis and tumor metastasis. Patients who received gallbladder surgery had significantly better survival outcomes (p<0.001), but patients who received both gallbladder and lymph node surgery did not have better survival outcome compared with patients receiving only gallbladder surgery. Multivariate Cox proportional hazard models indicated age, marital status, tumor size, and SEER stage were significant independent predictors for overall survival and cancer-specific survival (p<0.05).

Conclusion: Age, marital status, tumor size, and SEER stage were predictors for the survival of GB-NEN patients. Gallbladder surgery was associated with better survival, but the combination of gallbladder surgery and lymphadenectomy had no effect on survival outcomes.