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Samira M Sadowski, Emanuel Christ, Benoit Bédat, Attila Kollár, Wolfram Karenovics, Aurel Perren, Frédéric Triponez, and on behalf of the SwissNET registry

and etoposide therapy and underwent additional treatments in form of RFA and external radiation. Survival analysis Overall, analysis shows that the mean survival for TC tended to be longer, at 86.1 months compared to 48.4 months for AC, P  = 0

Open access

Olof Joakim Pettersson, Katarzyna Fröss-Baron, Joakim Crona, and Anders Sundin

landmark had been applied. TGR at the various intervals in the survival analysis were designated ‘TGR 0surv ’, ‘TGR 4surv ’ and ‘TGR 10surv ’ (please see also the ‘Statistical analysis’ section below). Statistical analysis Kruskal–Wallis one

Open access

Yang Lv, Ning Pu, Wei-lin Mao, Wen-qi Chen, Huan-yu Wang, Xu Han, Yuan Ji, Lei Zhang, Da-yong Jin, Wen-Hui Lou, and Xue-feng Xu

classification, compared with 45 and 30% for the AJCC N0/N1 and N2 classification groups (log-rank χ 2  = 18.08, P  < 0.05 and log-rank = 27.92, P  = 0.00, respectively). From the multivariate survival analysis, the N, M stage and grade were indicated as the

Open access

Enrique Soto-Pedre, Paul J Newey, John S Bevan, and Graham P Leese

, respectively. Non-parametric methods were used where appropriate. Survival analysis was performed to follow-up patients and Cox proportional hazards’ models using the robust variance estimator were used to explore the relationship between exposure to

Open access

Wentao Zhou, Tiantao Kuang, Xu Han, Wenqi Chen, Xuefeng Xu, Wenhui Lou, and Dansong Wang

cut-off values of LMR for G1, G2 and G3 were 5.0, 4.4 and 3.5, respectively (Supplementary Fig. 4). Survival analysis manifested that LMR >4.4 was associated with favorable prognosis in G2 patients ( P  = 0.020), but no statistical difference was

Open access

Jung Soo Lim, Seung-Eun Lee, Jung Hee Kim, Jae Hyeon Kim, and The Korean Adrenal Gland and Endocrine Hypertension Study Group, Korean Endocrine Society


To evaluate the clinical characteristics and prognostic factors in patients with adrenocortical carcinoma (ACC) in South Korea.


A nationwide, registry-based survey was conducted to identify pathologically proven ACC at 25 tertiary care centers in South Korea between 2000 and 2014. Cox proportional hazard model and log-rank test were adopted for survival analysis.


Two hundred four patients with ACC were identified, with a median follow-up duration of 20 months (IQR 5–52 months). The median age at diagnosis was 51.5 years (IQR 40–65.8 years), and ACC was prevalent in women (n = 110, 53.9%). Abdominal pain was the most common clinical symptom (n = 70, 40.2%), and ENSAT stage 2 was most common (n = 62, 30.4%) at the time of diagnosis. One hundred sixty-nine patients underwent operation, while 17 were treated with other modalities. The remission rate was 48%, and median recurrence-free survival time was 46 months. Estimated 5-year recurrence-free rate was 44.7%. There were more women, large tumor, atypical mitosis, venous invasion, and higher mitotic count in cancer recurrence group. Estimated 5-year overall survival and disease-specific survival rates were 64.5 and 70.6%, respectively. Higher ENSAT stage and advanced pathologic characteristics were risk factors for all-cause mortality of ACC. Large tumor size and cortisol-secreting tumor were additional risk factors for ACC-specific death.


We report the first epidemiologic study regarding ACC in an Asian population. ENSAT stage 4; lymph node involvement; non-operative group; and invasion of vein, sinusoid, or capsule were associated with an increased risk for all-cause mortality.

Open access

Chao-bin He, Yu Zhang, Zhi-yuan Cai, and Xiao-jun Lin

cancers ( 17 , 19 ). In addition, competing risk analysis, which has been used for many tumor, such as pancreatic cancer ( 18 ), lung cancer ( 34 ) and melanoma ( 39 ), should be considered in survival analysis for patients with PNETs. However, no study

Open access

Erika Urbano Lima, Ileana G S Rubio, Joaquim Custodio Da Silva, Ana Luiza Galrão, Danielle Pêssoa, Taise Cerqueira Oliveira, Fabiane Carrijo, Igor Silva Campos, Luciano Fonseca Espinheira, Luiz Jose Sampaio, Claudio Rogerio Lima, Janete Maria Cerutti, and Helton Estrela Ramos

–Meier method using log-rank test was used for survival analysis and Cox proportional hazard model for multivariate prognosis analysis. The value of P  < 0.05 was considered significant. Results HOPX-β expression and methylation status in thyroid

Open access

Xu Han, Xuefeng Xu, Hongyun Ma, Yuan Ji, Dansong Wang, Tiantao Kuang, Wenchuan Wu, Bin Song, Gang Li, Gang Jin, and Wenhui Lou

/oxaliplatin-based regimens). Initial chemotherapies in combination with other therapies were as follows: one patient had received HACE, one patient had received RFA, one patient had received everolimus and one patient had received radiotherapy. Survival analysis and

Open access

Dong Cen, Hui Liu, Zhe Wan, Zhongjie Lin, Yanting Wang, Junjie Xu, and Yuelong Liang

. Cancer-specific survival (CSS), as the primary endpoint, was determined as the date of diagnosis to the date of cancer-specific death. The Kaplan–Meier method along with the log-rank test was performed for survival analysis. Multivariate Cox proportional