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Endocrine Unit, Department of Medicine, Endocrine Unit, Faculty of Health Sciences, Department of Medicine O, Herlev University Hospital, Herlev Ringvej, DK-2730 Herlev, Denmark
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healthy euthyroid subjects, ∼20% of T 3 is derived from thyroidal secretion and the remaining from local production (2) . By contrast, hypothyroid subjects substituted with levothyroxine ( l -T 4 ) monotherapy demonstrated higher plasma T 4 /T 3 ratio
Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark
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Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Department of Clinical Physiology and Nuclear Medicine, Bispebjerg and Frederiksberg Hospital, University of Copenhagen, Copenhagen, Denmark
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Department of Clinical Pharmacology, Bispebjerg and Frederiksberg Hospital, University of Copenhagen, Copenhagen, Denmark
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Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Steno Diabetes Center Copenhagen, Herlev, Denmark
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Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Steno Diabetes Center Copenhagen, Herlev, Denmark
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Introduction Hypothyroidism is a common endocrine disease, affecting about 3% of the general population ( 1 ), with levothyroxine substitution therapy being the standard treatment ( 2 , 3 ). Hypothyroidism is associated with increased body
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, there should be caution when applying the results of this study under some circumstances. Conclusion Based on the results of this study, we conclude that it is reasonable for LBP to be substituted for CS of FNAC of thyroid lesions for the
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intron 1 of ERA gene in which thymine is substituted by cytosine (T→C). The presence of the dominant T allele of PvuII polymorphism can enhance ERA activity ( 11 ). Although increased reproductive efficiency has been associated with wildtype allele of
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Section of Biostatistics, Department of Public Health, University of Copenhagen, Copenhagen, Denmark
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substitution. Pubertal timing was assessed by an increase in serum total testosterone and luteinizing hormone (LH). Further, bone age (BA), assessed by the method of Greulich and Pyle ( 10 ), was evaluated in relation to chronological age (CA
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. However, it gives an indication that the weekly dose varies enormously between users and that the mean dose is highly supraphysiologic. For comparison, a normal substitution dose of an injectable testosterone-ester to treat male hypogonadism should not
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Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, Ludwig-Maximilians-Universität München, Munich, Germany
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, high doses of glucocorticoid substitution therapy and older age at diagnosis are the most consistently identified risk factors associated with increased morbidity and mortality ( 18 , 19 ). In addition, growth hormone deficiency (GHD) has been linked
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/fT4 ratio ( 4 , 5 ). A significant proportion of adult patients receiving LT4 therapy for hypothyroidism nevertheless report physical and mental fatigue ( 6 , 7 , 8 , 9 ). Even adequate substitution with LT4 and resulting fT4 levels at the upper
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9G12 ELISA To determine whether the glycosylation of N347 within the RCL of human CBG influences its measurements in ELISAs, we expressed a CBG mutant in which T349 was substituted by alanine in WT CHO-S cells ( Fig. 1A ). This threonine lies just
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St.Anna Kinderspital, Medical University of Vienna, Vienna, Austria
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dosage, including all age groups, of 14.4 mg/m 2 BSA is within the current recommended range of substitution between 10–15mg/m 2 BSA ( 7 ). The median dosage also implies that 44% of all patients 41% of the patients older than 3 months) received a