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Kim Magaly Pabst Department of Nuclear Medicine, West German Cancer Center, University Hospital Essen, Essen, Germany
German Cancer Consortium (DKTK), Partner site University Hospital Essen, Essen, Germany

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Robert Seifert Department of Nuclear Medicine, West German Cancer Center, University Hospital Essen, Essen, Germany
German Cancer Consortium (DKTK), Partner site University Hospital Essen, Essen, Germany
Department of Nuclear Medicine, University Hospital Münster, Münster, Germany

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Nader Hirmas Department of Nuclear Medicine, West German Cancer Center, University Hospital Essen, Essen, Germany
German Cancer Consortium (DKTK), Partner site University Hospital Essen, Essen, Germany

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Martina Broecker-Preuss Department of Medicine, Ruhr-University Bochum, University Hospital, Knappschaftskrankenhaus Bochum, Bochum, Germany

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Manuel Weber Department of Nuclear Medicine, West German Cancer Center, University Hospital Essen, Essen, Germany
German Cancer Consortium (DKTK), Partner site University Hospital Essen, Essen, Germany

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Wolfgang Peter Fendler Department of Nuclear Medicine, West German Cancer Center, University Hospital Essen, Essen, Germany
German Cancer Consortium (DKTK), Partner site University Hospital Essen, Essen, Germany

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Timo Bartel Department of Nuclear Medicine, West German Cancer Center, University Hospital Essen, Essen, Germany
German Cancer Consortium (DKTK), Partner site University Hospital Essen, Essen, Germany

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Sarah Theurer German Cancer Consortium (DKTK), Partner site University Hospital Essen, Essen, Germany
Institute of Pathology, University Hospital Essen, University Duisburg-Essen, Essen, Germany

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Ken Herrmann Department of Nuclear Medicine, West German Cancer Center, University Hospital Essen, Essen, Germany
German Cancer Consortium (DKTK), Partner site University Hospital Essen, Essen, Germany

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Rainer Görges Department of Nuclear Medicine, West German Cancer Center, University Hospital Essen, Essen, Germany
German Cancer Consortium (DKTK), Partner site University Hospital Essen, Essen, Germany

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Current guidelines for differentiated thyroid carcinoma (DTC) ( 1 , 2 ) assign a crucial diagnostic importance to stimulated thyroglobulin (s-Tg) measurement 6–12 months after completion of primary therapy to predict a recurrence-free follow-up than in

Article Type:
Research Article
Collections:
Thyroid
DOI:
https://doi.org/10.1530/EC-22-0312
Volume/Issue:
Volume 12: Issue 2
Open access
Teresa Kraus Division of Nuclear Medicine, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria

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Natalia Shengelia-de Lange Division of Nuclear Medicine, Tbilisi State Medical University, Tbilisi, Georgia

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Holger Einspieler Division of Nuclear Medicine, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria

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Marcus Hacker Division of Nuclear Medicine, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria

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Alexander Haug Division of Nuclear Medicine, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria

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Elisabeth Kretschmer-Chott Division of Nuclear Medicine, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria

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Georgios Karanikas Division of Nuclear Medicine, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria

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Augello G D’Aloiso L Bonfitto N Varraso A Dicembrino F Modoni S Frusciante V Giorgio AD , et al. Comparative evaluation of recombinant human thyrotropin-stimulated thyroglobulin levels, 131I whole-body scintigraphy, and neck

Article Type:
Research Article
Collections:
Thyroid
DOI:
https://doi.org/10.1530/EC-24-0007
Volume/Issue:
Volume 13: Issue 5
Open access
Sara Ahmadi Thyroid Section Brigham & Women’s Hospital & Harvard Medical School, Boston, Massachusetts, USA

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Alexandra Coleman Thyroid Section Brigham & Women’s Hospital & Harvard Medical School, Boston, Massachusetts, USA

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Nathalie Silva de Morais Thyroid Section Brigham & Women’s Hospital & Harvard Medical School, Boston, Massachusetts, USA
Endocrinology Service, Instituto Nacional de Câncer, Rio de Janeiro, Brazil

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Iñigo Landa Thyroid Section Brigham & Women’s Hospital & Harvard Medical School, Boston, Massachusetts, USA

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Theodora Pappa Thyroid Section Brigham & Women’s Hospital & Harvard Medical School, Boston, Massachusetts, USA

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Alex Kang Thyroid Section Brigham & Women’s Hospital & Harvard Medical School, Boston, Massachusetts, USA

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Matthew I Kim Thyroid Section Brigham & Women’s Hospital & Harvard Medical School, Boston, Massachusetts, USA

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Ellen Marqusee Thyroid Section Brigham & Women’s Hospital & Harvard Medical School, Boston, Massachusetts, USA

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Erik K Alexander Thyroid Section Brigham & Women’s Hospital & Harvard Medical School, Boston, Massachusetts, USA

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, stimulated thyroglobulin (Tg) was available in 43 (40%) patients (mean Tg = 15.8, s.d. 9.4), while 51 (47%) patients had positive thyroglobulin antibodies. In the SPECT-CT cohort, stimulated thyroglobulin was available in 63 (60%) patients (mean 9.1, s

Article Type:
Research Article
Collections:
Thyroid
DOI:
https://doi.org/10.1530/EC-21-0371
Volume/Issue:
Volume 11: Issue 5
Open access
Danuta Gąsior-Perczak Endocrinology Clinic, Holycross Cancer Centre, Kielce, Poland

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Iwona Pałyga Endocrinology Clinic, Holycross Cancer Centre, Kielce, Poland

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Monika Szymonek Endocrinology Clinic, Holycross Cancer Centre, Kielce, Poland

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Artur Kowalik Department of Molecular Diagnostics, Holycross Cancer Centre, Kielce, Poland

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Agnieszka Walczyk Endocrinology Clinic, Holycross Cancer Centre, Kielce, Poland

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Janusz Kopczyński Department of Surgical Pathology, Holycross Cancer Centre, Kielce, Poland

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Katarzyna Lizis-Kolus Endocrinology Clinic, Holycross Cancer Centre, Kielce, Poland

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Anna Słuszniak Laboratory of Tumor Markers, Holycross Cancer Centre, Kielce, Poland

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Janusz Słuszniak Department of Surgical Oncology, Holycross Cancer Centre, Kielce, Poland

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Tomasz Łopatyński Department of Surgery, Oncology Center of Lublin Land, Lublin, Poland

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Ryszard Mężyk Cancer Epidemiology, Holycross Cancer Centre, Kielce, Poland

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Stanisław Góźdź Oncology Clinic, Holycross Cancer Centre, Kielce, Poland
The Faculty of Health Sciences, Jan Kochanowski University, Kielce, Poland

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Aldona Kowalska Endocrinology Clinic, Holycross Cancer Centre, Kielce, Poland
The Faculty of Health Sciences, Jan Kochanowski University, Kielce, Poland

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.1371/journal.pone.0153242 27078258 16 Kowalska A Pałyga I Gąsior-Perczak D Walczyk A Trybek T Słuszniak A Mężyk R Góźdź S . The cut-off level of recombinant human TSH-stimulated thyroglobulin in the follow-up of patients with

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-17-0135
Volume/Issue:
Volume 6: Issue 7
Open access
S C Clement Department of Pediatrics, Emma Children’s Hospital, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Department of Pediatric Endocrinology, Wilhelmina Children’s Hospital/ University Medical Center Utrecht, Utrecht, The Netherlands

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W E Visser Academic Center For Thyroid Disease, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands

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C A Lebbink Department of Pediatric Endocrinology, Wilhelmina Children’s Hospital/ University Medical Center Utrecht, Utrecht, The Netherlands
Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands

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D Albano Department of Nuclear Medicine, University of Brescia and Spedali Civili of Brescia, Brescia, Italy

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H L Claahsen-van der Grinten Department of Pediatrics, Radboud University Medical Center, Amalia Children's Hospital, Nijmegen, The Netherlands

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A Czarniecka The Oncologic and Reconstructive Surgery Clinic, M. Sklodowska-Curie National Research Institute of Oncology Gliwice Branch, Gliwice, Poland

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R P Dias Department of Endocrinology and Diabetes, Birmingham Children’s Hospital, Birmingham Women’s, and Children’s NHS Foundation Trust, Birmingham, UK
Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK

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M P Dierselhuis Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands

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I Dzivite-Krisane Department of Pediatric Endocrinology, Children's Clinical University Hospital, Riga, Latvia

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R Elisei Endocrine Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy

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A Garcia-Burillo Nuclear Medicine Department, Vall d'Hebron University Hospital, Barcelona, Spain

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L Izatt Department of Clinical Genetics, Guy's and St Thomas’ NHS Foundation Trust, London, UK

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C Kanaka-Gantenbein Division of Endocrinology, Diabetes, and Metabolism, First Department of Pediatrics National and Kapodistrian University of Athens Medical School, Aghia Sophia Children's Hospital, Athens, Greece

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H Krude Institute of Experimental Pediatric Endocrinology, Charité - Universitätsmedizin, Berlin, Germany

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L Lamartina Department of Endocrine Oncology, Gustave Roussy, Villejuif, France

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K Lorenz Department of Visceral, Vascular and Endocrine Surgery, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany

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M Luster Department of Nuclear Medicine, University Hospital Marburg, Marburg, Germany

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R Navardauskaitė Department of Endocrinology, Lithuanian University of Health Sciences, Kaunas, Lithuania

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M Negre Busó Nuclear Medicine Service - Institut de diagnòstic per la Imatge, Hospital Universitari de Girona Dr. Josep Trueta, Girona, Spain

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K Newbold Thyroid Therapy Unit, The Royal Marsden NHS Foundation Trust Hospital, London, UK

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R P Peeters Academic Center For Thyroid Disease, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands

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G Pellegriti Endocrinology, Endocrinology Division, Garibaldi-Nesima Medical Center, Catania, Italy

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A Piccardo Department of Nuclear Medicine, EO Ospedali Galliera, Genoa, Italy

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A L Priego Department of Medicine, Division of Endocrinology, Leiden, University medical Center, Leiden, The Netherlands

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A Redlich Pediatric Oncology Department, Otto von Guericke University Children's Hospital, Magdeburg, Germany

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L de Sanctis Regina Margherita Children Hospital - Department of Public Health and Pediatric Sciences, University of Torino, Torino, Italy

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M Sobrinho-Simões University Hospital of São João, Medical Faculty and Institute of Molecular Pathology and Immunology, University of Porto, Porto, Portugal

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A S P van Trotsenburg Department of Pediatric Endocrinology, Emma Children’s Hospital, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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F A Verburg Department of Radiology & Nuclear Medicine, Erasmus MC Rotterdam, Rotterdam, The Netherlands

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M Vriens Department of Endocrine Surgery, University Medical Center Utrecht, Utrecht, The Netherlands

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T P Links Department of Endocrinology, University Medical Center Groningen, Groningen, The Netherlands

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S F Ahmed Endocrinology, Endocrinology Division, Garibaldi-Nesima Medical Center, Catania, Italy
Developmental Endocrinology Research Group, Royal Hospital for Children, University of Glasgow, Glasgow, UK
Office for Rare Conditions, University of Glasgow, Glasgow, UK

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H M van Santen Department of Pediatric Endocrinology, Wilhelmina Children’s Hospital/ University Medical Center Utrecht, Utrecht, The Netherlands
Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands

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Tsagarakis S . Long-term outcome of differentiated thyroid cancer in children and young adults: risk stratification by ATA criteria and assessment of pre-ablation stimulated thyroglobulin as predictors of disease persistence . Endocrine 2020 70 566 – 574

Article Type:
Research Article
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Thyroid
DOI:
https://doi.org/10.1530/EC-22-0306
Volume/Issue:
Volume 12: Issue 3
Open access
Norra Kwong Division of Endocrinology, Endocrine Division, Hypertension and Diabetes, Thyroid Section, Brigham and Women's Hospital, Harvard Medical School, 221 Longwood Avenue Boston, Massachusetts 02115, USA

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Ellen Marqusee Division of Endocrinology, Endocrine Division, Hypertension and Diabetes, Thyroid Section, Brigham and Women's Hospital, Harvard Medical School, 221 Longwood Avenue Boston, Massachusetts 02115, USA

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Michael S Gordon Division of Endocrinology, Endocrine Division, Hypertension and Diabetes, Thyroid Section, Brigham and Women's Hospital, Harvard Medical School, 221 Longwood Avenue Boston, Massachusetts 02115, USA
Division of Endocrinology, Endocrine Division, Hypertension and Diabetes, Thyroid Section, Brigham and Women's Hospital, Harvard Medical School, 221 Longwood Avenue Boston, Massachusetts 02115, USA

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P Reed Larsen Division of Endocrinology, Endocrine Division, Hypertension and Diabetes, Thyroid Section, Brigham and Women's Hospital, Harvard Medical School, 221 Longwood Avenue Boston, Massachusetts 02115, USA

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Jeffrey R Garber Division of Endocrinology, Endocrine Division, Hypertension and Diabetes, Thyroid Section, Brigham and Women's Hospital, Harvard Medical School, 221 Longwood Avenue Boston, Massachusetts 02115, USA
Division of Endocrinology, Endocrine Division, Hypertension and Diabetes, Thyroid Section, Brigham and Women's Hospital, Harvard Medical School, 221 Longwood Avenue Boston, Massachusetts 02115, USA

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Matthew I Kim Division of Endocrinology, Endocrine Division, Hypertension and Diabetes, Thyroid Section, Brigham and Women's Hospital, Harvard Medical School, 221 Longwood Avenue Boston, Massachusetts 02115, USA

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Erik K Alexander Division of Endocrinology, Endocrine Division, Hypertension and Diabetes, Thyroid Section, Brigham and Women's Hospital, Harvard Medical School, 221 Longwood Avenue Boston, Massachusetts 02115, USA

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-sectional imaging. Stimulated thyroglobulin ranged from 1.9 to 2.5 ng/ml over the first 6 years, though was once reported as undetectable. However, she later developed anti-thyroglobulin antibodies, which have since persisted. At the age of 40, PET scanning revealed

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-14-0097
Volume/Issue:
Volume 3: Issue 4
Open access
Pan Chen Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China

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Liqin Pan Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China

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Wensi Huang Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China

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Huijuan Feng Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China

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Wei Ouyang Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China

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Juqing Wu Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China

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Jing Wang Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China

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Yuying Deng Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China

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Jiaxin Luo Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China

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Yanying Chen Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China

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according to 2015 ATA guidelines ( 7 ). The patients followed a low-iodine diet for 3–4 weeks and thyroid hormone withdrawal at least 3 weeks before 131 I therapy. The oral 131 I dose depended on the postoperative risk stratification and stimulated

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-20-0420
Volume/Issue:
Volume 9: Issue 10
Open access
Thomas Crezee Department of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands
Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen, The Netherlands

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Mirela Petrulea Department of Endocrinology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania

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Doina Piciu Department of Endocrinology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania
Division of Endocrinology, Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands

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Martin Jaeger Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen, The Netherlands
Department of Nuclear Medicine and Endocrine Tumors, Institute of Oncology ‘Prof. Dr. Ion Chiricuta’, Cluj-Napoca, Romania

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Jan W A Smit Division of Endocrinology, Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands

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Theo S Plantinga Department of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands
Department of Nuclear Medicine and Endocrine Tumors, Institute of Oncology ‘Prof. Dr. Ion Chiricuta’, Cluj-Napoca, Romania

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Carmen E Georgescu Department of Endocrinology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania
Endocrinology Clinic, Cluj County Emergency Hospital, Cluj-Napoca, Romania

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Romana Netea-Maier Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen, The Netherlands
Department of Nuclear Medicine and Endocrine Tumors, Institute of Oncology ‘Prof. Dr. Ion Chiricuta’, Cluj-Napoca, Romania

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stimulated thyroglobulin (Tg, <1 pmol/L in the Dutch patients and <0.04 ng/mL in the Romanian patients) in the absence of anti-Tg antibodies and no evidence of loco-regional disease or distant metastasis on the whole body iodine scans (WBS) and/or neck

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-20-0311
Volume/Issue:
Volume 9: Issue 11
Open access
Catarina Tavares Instituto de Investigação e Inovação em Saúde (i3S), Porto, Portugal
Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal
Medical Faculty of the University of Porto, Porto, Portugal

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Maria João Coelho Instituto de Investigação e Inovação em Saúde (i3S), Porto, Portugal
Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal
Institute of Biomedical Sciences of Abel Salazar (ICBAS), Porto, Portugal

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Catarina Eloy Instituto de Investigação e Inovação em Saúde (i3S), Porto, Portugal
Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal
Medical Faculty of the University of Porto, Porto, Portugal

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Miguel Melo Instituto de Investigação e Inovação em Saúde (i3S), Porto, Portugal
Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal
Department of Endocrinology, Diabetes and Metabolism, University and Hospital Center of Coimbra, Coimbra, Portugal
Medical Faculty, University of Coimbra, Coimbra, Portugal

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Adriana Gaspar da Rocha Instituto de Investigação e Inovação em Saúde (i3S), Porto, Portugal
Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal
Public Health Unit, ACeS Baixo Mondego, Coimbra, Portugal

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Ana Pestana Instituto de Investigação e Inovação em Saúde (i3S), Porto, Portugal
Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal
Medical Faculty of the University of Porto, Porto, Portugal

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Rui Batista Instituto de Investigação e Inovação em Saúde (i3S), Porto, Portugal
Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal
Medical Faculty of the University of Porto, Porto, Portugal

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Luciana Bueno Ferreira Instituto de Investigação e Inovação em Saúde (i3S), Porto, Portugal
Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal
Medical Faculty of the University of Porto, Porto, Portugal

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Elisabete Rios Instituto de Investigação e Inovação em Saúde (i3S), Porto, Portugal
Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal
Medical Faculty of the University of Porto, Porto, Portugal
Department of Pathology, Medical Faculty of the University of Porto, Porto, Portugal
Department of Pathology, Hospital de S. João, Porto, Portugal

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Samia Selmi-Ruby Inserm UMR-S1052, CNRS UMR5286, Centre de Recherche en Cancérologie de Lyon, Lyon, France

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Bruno Cavadas Instituto de Investigação e Inovação em Saúde (i3S), Porto, Portugal
Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal
Institute of Biomedical Sciences of Abel Salazar (ICBAS), Porto, Portugal

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Luísa Pereira Instituto de Investigação e Inovação em Saúde (i3S), Porto, Portugal
Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal
Medical Faculty of the University of Porto, Porto, Portugal

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Manuel Sobrinho Simões Instituto de Investigação e Inovação em Saúde (i3S), Porto, Portugal
Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal
Medical Faculty of the University of Porto, Porto, Portugal
Department of Pathology, Medical Faculty of the University of Porto, Porto, Portugal
Department of Pathology, Hospital de S. João, Porto, Portugal

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Paula Soares Instituto de Investigação e Inovação em Saúde (i3S), Porto, Portugal
Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal
Medical Faculty of the University of Porto, Porto, Portugal
Department of Pathology, Medical Faculty of the University of Porto, Porto, Portugal

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protocols available at the time. Data regarding the number of radioiodine treatments and cumulative activity were retrieved from hospital records. Patients were considered as being disease-free at the end of follow-up if they had undetectable stimulated

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-17-0302
Volume/Issue:
Volume 7: Issue 1
Open access