in widespread use since publication in 2007 of the large retrospective study of Terzolo et al . (3) . Accumulated knowledge of the mode of action of mitotane together with its effects on steroid synthesis and catabolism is patchy. Mitotane targets
Effects of mitotane treatment on human steroid metabolism: implications for patient management
L Ghataore, I Chakraborti, S J Aylwin, K-M Schulte, D Dworakowska, P Coskeran, and N F Taylor
Sex-specific differences in HPA axis activity in VLBW preterm newborns
Britt J van Keulen, Michelle Romijn, Bibian van der Voorn, Marita de Waard, Michaela F Hartmann, Johannes B van Goudoever, Stefan A Wudy, Joost Rotteveel, and Martijn J J Finken
and thawed only once just before analysis. After placement in a salivette, the pad was centrifuged at 1900 g for 5 min, enabling the extraction of urine. Urinary steroids were determined using quantitative data produced by gas chromatography
HIIT produces increases in muscle power and free testosterone in male masters athletes
P Herbert, LD Hayes, NF Sculthorpe, and FM Grace
-frequency HIIT would improve PPO compared with normal exercise training and (ii) systemic steroid hormones would be unchanged following low-frequency HIIT in masters athletes. Materials and methods Participants Following familiarization with
Sexual dimorphism in cortisol metabolism throughout pubertal development: a longitudinal study
Britt J van Keulen, Conor V Dolan, Bibian van der Voorn, Ruth Andrew, Brian R Walker, Hilleke Hulshoff Pol, Dorret I Boomsma, Joost Rotteveel, and Martijn J J Finken
cortisol levels. Compared to girls, boys, up to age 8, had higher salivary cortisol levels and lower levels beyond this age ( 11 ). The timing of this change suggests that sex steroids influence the HPA axis. Surprisingly, to the best of our knowledge
Steroid metabolomic signature of liver disease in nonsyndromic childhood obesity
Aneta Gawlik, Michael Shmoish, Michaela F Hartmann, Stefan A Wudy, Zbigniew Olczak, Katarzyna Gruszczynska, and Ze’ev Hochberg
there is possibility of multiple diagnoses or before starting therapy with potentially hepatotoxic medications’ ( 8 ). The consequences of obesity-related NAFLD on liver metabolism are insufficiently understood ( 8 ). As steroid hormones are partially
Higher steroid sulfation is linked to successful weight loss in obese children
Thomas Reinehr, Alberto Sánchez-Guijo, Nina Lass, and Stefan A Wudy
Introduction Obesity is a complex condition associated with changes in many steroid hormones also including androgens: concentrations of testosterone and DHEAS and their precursors are increased in children ( 1 , 2 ) and obese women ( 3
Exercise training improves free testosterone in lifelong sedentary aging men
Lawrence D Hayes, Peter Herbert, Nicholas F Sculthorpe, and Fergal M Grace
Introduction Testosterone is a sex steroid hormone with profound influence on various tissues ( 1 , 2 , 3 ). The precipitous decline in systemic testosterone with age is well described ( 4 ). Additionally, sex hormone-binding globulin (SHBG
Anabolic androgenic steroid abuse in young males
Willem de Ronde and Diederik L Smit
Introduction Every now and then a clinical endocrinologist will be visited by a patient that uses anabolic androgenic steroids (AAS) or has been using them in the past. The interaction between doctor and patient may be hampered for a number of
Diurnal variation of steroid hormones and their reference intervals using mass spectrometric analysis
T P Parikh, B Stolze, Y Ozarda, J Jonklaas, K Welsh, L Masika, M Hill, A DeCherney, and S J Soldin
Introduction Diurnal variations in the serum concentration of steroid hormones and their metabolism, as assessed by urinary excretion, have long been known for cortisol and testosterone ( 1 , 2 , 3 ). Less information exists for the other up
Assay of steroids by liquid chromatography–tandem mass spectrometry in monitoring 21-hydroxylase deficiency
Sandra R Dahl, Ingrid Nermoen, Ingeborg Brønstad, Eystein S Husebye, Kristian Løvås, and Per M Thorsby
assessment is not sensitive enough to identify subtle over- and under-treatment. Assay of the intermediates 17-hydroxyprogesterone (17OHP) and androstenedione is often used, but results are often difficult to interpret as cross-reactivity between steroids
