in widespread use since publication in 2007 of the large retrospective study of Terzolo et al . (3) . Accumulated knowledge of the mode of action of mitotane together with its effects on steroid synthesis and catabolism is patchy. Mitotane targets
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L Ghataore, I Chakraborti, S J Aylwin, K-M Schulte, D Dworakowska, P Coskeran, and N F Taylor
P Herbert, LD Hayes, NF Sculthorpe, and FM Grace
-frequency HIIT would improve PPO compared with normal exercise training and (ii) systemic steroid hormones would be unchanged following low-frequency HIIT in masters athletes. Materials and methods Participants Following familiarization with
Britt J van Keulen, Conor V Dolan, Bibian van der Voorn, Ruth Andrew, Brian R Walker, Hilleke Hulshoff Pol, Dorret I Boomsma, Joost Rotteveel, and Martijn J J Finken
cortisol levels. Compared to girls, boys, up to age 8, had higher salivary cortisol levels and lower levels beyond this age ( 11 ). The timing of this change suggests that sex steroids influence the HPA axis. Surprisingly, to the best of our knowledge
Britt J van Keulen, Michelle Romijn, Bibian van der Voorn, Marita de Waard, Michaela F Hartmann, Johannes B van Goudoever, Stefan A Wudy, Joost Rotteveel, and Martijn J J Finken
and thawed only once just before analysis. After placement in a salivette, the pad was centrifuged at 1900 g for 5 min, enabling the extraction of urine. Urinary steroids were determined using quantitative data produced by gas chromatography
Lawrence D Hayes, Peter Herbert, Nicholas F Sculthorpe, and Fergal M Grace
Introduction Testosterone is a sex steroid hormone with profound influence on various tissues ( 1 , 2 , 3 ). The precipitous decline in systemic testosterone with age is well described ( 4 ). Additionally, sex hormone-binding globulin (SHBG
Willem de Ronde and Diederik L Smit
Introduction Every now and then a clinical endocrinologist will be visited by a patient that uses anabolic androgenic steroids (AAS) or has been using them in the past. The interaction between doctor and patient may be hampered for a number of
Aneta Gawlik, Michael Shmoish, Michaela F Hartmann, Stefan A Wudy, Zbigniew Olczak, Katarzyna Gruszczynska, and Ze’ev Hochberg
there is possibility of multiple diagnoses or before starting therapy with potentially hepatotoxic medications’ ( 8 ). The consequences of obesity-related NAFLD on liver metabolism are insufficiently understood ( 8 ). As steroid hormones are partially
T P Parikh, B Stolze, Y Ozarda, J Jonklaas, K Welsh, L Masika, M Hill, A DeCherney, and S J Soldin
Introduction Diurnal variations in the serum concentration of steroid hormones and their metabolism, as assessed by urinary excretion, have long been known for cortisol and testosterone ( 1 , 2 , 3 ). Less information exists for the other up
Sandra R Dahl, Ingrid Nermoen, Ingeborg Brønstad, Eystein S Husebye, Kristian Løvås, and Per M Thorsby
assessment is not sensitive enough to identify subtle over- and under-treatment. Assay of the intermediates 17-hydroxyprogesterone (17OHP) and androstenedione is often used, but results are often difficult to interpret as cross-reactivity between steroids
Thomas Reinehr, Alberto Sánchez-Guijo, Nina Lass, and Stefan A Wudy
Introduction Obesity is a complex condition associated with changes in many steroid hormones also including androgens: concentrations of testosterone and DHEAS and their precursors are increased in children ( 1 , 2 ) and obese women ( 3