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Monia Cito, Silvia Pellegrini, Lorenzo Piemonti, and Valeria Sordi

variability of isolated human islets and the need for lifelong immunosuppression. Different approaches using stem cells to support islet survival and function are being explored in preclinical and clinical settings ( 5 ). Now, the most advanced strategies to

Open access

Earn H Gan, Wendy Robson, Peter Murphy, Robert Pickard, Simon Pearce, and Rachel Oldershaw

capacity of rodent adrenal capsule nearly 80 years ago ( 4 ), the exact in vivo identity of adrenocortical stem cells (ACSCs) remains elusive. Adult mesenchymal stromal or stem cells (MSCs) have drawn significant interest among researchers in the stem

Open access

Luminita Nicoleta Cima, Anca Colita, and Simona Fica

Introduction Hematopoietic stem cell transplantation (HSCT) is increasingly used for the treatment of both malignant and nonmalignant diseases. Survival after autologous/allogeneic HSCT is no longer the highest concern, as many patients

Open access

Sidsel Mathiesen, Kaspar Sørensen, Marianne Ifversen, Casper P Hagen, Jørgen Holm Petersen, Anders Juul, and Klaus Müller

Introduction Hematopoietic stem cell transplantation (HSCT) is a potentially curative treatment for children with life-threatening hematological and immunological diseases, including high-risk leukemias, but late effects are becoming prevalent

Open access

Melissa Braga, Zena Simmons, Keith C Norris, Monica G Ferrini, and Jorge N Artaza

muscle stem cells’, have a remarkable ability to regenerate after muscle injury and are responsible for compensation of muscle turnover caused by daily wear and tear. In this study, we expand our previous results and conclusions ( 11 , 12 ) by now

Open access

Tatiana V Novoselova, Peter J King, Leonardo Guasti, Louise A Metherell, Adrian J L Clark, and Li F Chan

absent ACTH action contribute to the expansion of the stem cell niche in the adrenal gland, in keeping with some of the data described above. Treatment of WT control mice with glucocorticoid resulted in biochemically undetectable plasma ACTH coupled with

Open access

Jan-Bernd Stukenborg, Kirsi Jahnukainen, Marsida Hutka, and Rod T Mitchell

Introduction Fertility in males is dependent on the presence of a germ cell population that is capable of developing into sperm in adulthood. However, the ability of spermatogonial stem cells (SSC) to give rise to sperm is dependent on the

Open access

Sandrine Visentin, Gérard Michel, Claire Oudin, Béatrice Cousin, Bénédicte Gaborit, Inès Abdesselam, Marie Maraninchi, Marion Nowicki, René Valéro, Maxime Guye, Monique Bernard, Pascal Auquier, Hervé Chambost, Marie-Christine Alessi, and Sophie Béliard

before hematopoietic stem-cell transplantation, represents a major risk factor for developing MS and CVD ( 10 , 11 , 12 , 13 , 14 , 15 ). In the LEA cohort, MS was found in 18.9% of young adults (mean age 21 years) who had received TBI during

Open access

Masatada Watanabe, Shuji Ohno, and Hiroshi Wachi

mechanisms between cells of hematopoietic stem cell origin and cells of mesenchymal stem cell origin. This difference might provide a basis for new tissue-specific or cell-specific pharmacotherapeutic utilization of glucocorticoids, β-agonists and β

Open access

Ying Hua, Jinqiong Fang, Xiaocong Yao, and Zhongxin Zhu

from bone marrow mesenchymal stem cells, and, thus, increasing adipogenic differentiation decreases osteogenic differentiation ( 20 ). Another possible explanation is that obesity-induced hypermetabolism caused by enhanced insulin signaling leads to