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Adrian F Daly Department of Endocrinology, Centre Hospitalier Universitaire (CHU) de Liège, Liège Université, Domaine Universitaire du Sart-Tilman, Liège, Belgium

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Liliya Rostomyan Department of Endocrinology, Centre Hospitalier Universitaire (CHU) de Liège, Liège Université, Domaine Universitaire du Sart-Tilman, Liège, Belgium

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Daniela Betea Department of Endocrinology, Centre Hospitalier Universitaire (CHU) de Liège, Liège Université, Domaine Universitaire du Sart-Tilman, Liège, Belgium

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Jean-François Bonneville Department of Endocrinology, Centre Hospitalier Universitaire (CHU) de Liège, Liège Université, Domaine Universitaire du Sart-Tilman, Liège, Belgium

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Chiara Villa Department of Endocrinology, Centre Hospitalier Universitaire (CHU) de Liège, Liège Université, Domaine Universitaire du Sart-Tilman, Liège, Belgium
Department of Pathological Cytology and Anatomy, Foch Hospital, Paris, France

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Natalia S Pellegata Institute for Diabetes and Cancer, Helmholtz Zentrum München, Neuherberg, Germany

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Beatrice Waser Division of Cell Biology and Experimental Cancer Research, Institute of Pathology, University of Bern, Bern, Switzerland

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Jean-Claude Reubi Division of Cell Biology and Experimental Cancer Research, Institute of Pathology, University of Bern, Bern, Switzerland

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Catherine Waeber Stephan Clinique Générale Ste-Anne, Fribourg, Switzerland

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Emanuel Christ Department of Endocrinology, Diabetology and Metabolism, University Hospital Basel, University of Basel, Basel, Switzerland

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Albert Beckers Department of Endocrinology, Centre Hospitalier Universitaire (CHU) de Liège, Liège Université, Domaine Universitaire du Sart-Tilman, Liège, Belgium

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; in particular those with AIP mutations have a significantly lower hormonal response to first-generation, receptor subtype 2 (SST2) specific somatostatin analogs (octreotide and lanreotide) and have a decreased rate of tumor shrinkage on treatment

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-19-0004
Volume/Issue:
Volume 8: Issue 4
Open access
Hélène Lasolle Fédération d’Endocrinologie, Centre de Référence Maladies Rares Hypophysaires HYPO, Groupement Hospitalier Est, Hospices Civils de Lyon, Bron, France
Faculté de Médecine Lyon Est, Université Lyon 1, Lyon, France
INSERM U1052; CNRS UMR5286; Cancer Research Centre of Lyon, Lyon, France

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Amandine Ferriere Service d’endocrinologie, diabète et nutrition, Hôpital Haut Lévêque, CHU de Bordeaux, Bordeaux, France
UFR Sciences médicales, Université de Bordeaux, Bordeaux, France

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Alexandre Vasiljevic Faculté de Médecine Lyon Est, Université Lyon 1, Lyon, France
INSERM U1052; CNRS UMR5286; Cancer Research Centre of Lyon, Lyon, France
Centre de Pathologie et de Neuropathologie Est, Groupement Hospitalier Est, Hospices Civils de Lyon, Bron, France

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Sandrine Eimer UFR Sciences médicales, Université de Bordeaux, Bordeaux, France
Service d’anatomo-pathologie, Hopital Pellegrin, CHU de Bordeaux, Bordeaux, France

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Marie-Laure Nunes Service d’endocrinologie, diabète et nutrition, Hôpital Haut Lévêque, CHU de Bordeaux, Bordeaux, France

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Antoine Tabarin Service d’endocrinologie, diabète et nutrition, Hôpital Haut Lévêque, CHU de Bordeaux, Bordeaux, France
UFR Sciences médicales, Université de Bordeaux, Bordeaux, France

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surgeon ( 2 ). Medical management of acromegaly is used when surgery fails to control the disease or when surgery cannot be performed ( 3 ). First-generation long-acting somatostatin analogs (1gSRL) (octreotide LAR and lanreotide Autogel) are the most

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-19-0332
Volume/Issue:
Volume 8: Issue 10
Open access
Mônica R Gadelha Endocrine Unit, Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

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Feng Gu Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Beijing, China

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Marcello D Bronstein Neuroendocrine Unit, Division of Endocrinology and Metabolism, University of São Paulo Medical School, São Paulo, Brazil

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Thierry C Brue Aix-Marseille Université, Institut National de la Santé et de la Recherche Médicale, Marseille Medical Genetics, and Assistance Publique Hôpitaux de Marseille, Department of Endocrinology, Hôpital de la Conception, Centre de Référence des Maladies Rares de l’Hypophyse, Marseille, France

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Maria Fleseriu Northwest Pituitary Center, Oregon Health & Science University, Portland, Oregon, USA

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Ilan Shimon Institute of Endocrinology and Metabolism, Rabin Medical Center, and Sackler School of Medicine, Tel-Aviv University, Petah-Tiqva, Israel

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Aart J van der Lely Erasmus University Medical Center, Rotterdam, The Netherlands

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Shoba Ravichandran Novartis Pharmaceuticals Corporation, East Hanover, New Jersey, USA

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Albert Kandra Recordati AG, Basel, Switzerland

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Alberto M Pedroncelli Recordati AG, Basel, Switzerland

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Annamaria A L Colao Dipartimento di Medicina Clinica e Chirurgia, Sezione di Endocrinologia, Università Federico II di Napoli, Naples, Italy

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with these agents ( 9 ). Long-acting pasireotide, a multireceptor-targeted somatostatin analog (SSA), has been evaluated in the Phase III SOM230C2305 (C2305) ( 10 ) and SOM230C2402 (C2402; PAOLA) ( 11 ) studies. Patients enrolled in study C2305 had

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-20-0361
Volume/Issue:
Volume 9: Issue 12
Open access
Alberto Bongiovanni Osteoncology and Rare Tumors Center, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy

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Federica Recine Osteoncology and Rare Tumors Center, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy

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Flavia Foca Unit of Biostatistics and Clinical Trials, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy

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Valentina Fausti Osteoncology and Rare Tumors Center, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy

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Nada Riva Osteoncology and Rare Tumors Center, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy

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Greta Fabbri Unit of Biostatistics and Clinical Trials, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy

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Stefano Severi Nuclear Medicine Unit, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy

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Chiara Liverani Osteoncology and Rare Tumors Center, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy

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Alessandro De Vita Osteoncology and Rare Tumors Center, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy

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Chiara Spadazzi Osteoncology and Rare Tumors Center, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy

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Giacomo Miserocchi Osteoncology and Rare Tumors Center, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy

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Laura Mercatali Osteoncology and Rare Tumors Center, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy

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Dino Amadori Osteoncology and Rare Tumors Center, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy

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Toni Ibrahim Osteoncology and Rare Tumors Center, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy

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reported in <15% of cases ( 7 ). Treatment options for metastatic disease comprise liver surgery and/or locoregional and ablative therapies, somatostatin analogs, chemotherapy, targeted therapy and peptide receptor radionuclide therapy ( 8 ). Given the

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-18-0478
Volume/Issue:
Volume 7: Issue 12
Open access
Adrian F Daly Department of Endocrinology, Centre Hospitalier Universitaire de Liège, Liège Université, Liège, Belgium

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David A Cano Unidad de Gestión de Endocrinología y Nutrición, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Sevilla, Spain

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Eva Venegas-Moreno Unidad de Gestión de Endocrinología y Nutrición, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Sevilla, Spain

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Patrick Petrossians Department of Endocrinology, Centre Hospitalier Universitaire de Liège, Liège Université, Liège, Belgium

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Elena Dios Unidad de Gestión de Endocrinología y Nutrición, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Sevilla, Spain

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Emilie Castermans Department of Human Genetics, Centre Hospitalier Universitaire de Liège, Liège Université, Liège, Belgium

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Alvaro Flores-Martínez Unidad de Gestión de Endocrinología y Nutrición, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Sevilla, Spain

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Vincent Bours Department of Human Genetics, Centre Hospitalier Universitaire de Liège, Liège Université, Liège, Belgium

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Albert Beckers Department of Endocrinology, Centre Hospitalier Universitaire de Liège, Liège Université, Liège, Belgium

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Alfonso Soto-Moreno Unidad de Gestión de Endocrinología y Nutrición, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Sevilla, Spain

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patients may be resistant to somatostatin analogs (SSA) that target the somatostatin receptor subtype 2 (SST2), while a small proportion of prolactinoma patients may not respond to labeled doses of dopamine agonists (DA). Hence, multimodal therapy involving

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-19-0027
Volume/Issue:
Volume 8: Issue 4
Open access
Paweł Komarnicki Department of Endocrinology, Metabolism and Internal Diseases, Poznan University of Medical Sciences, Poznań, Poland

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Paweł Gut Department of Endocrinology, Metabolism and Internal Diseases, Poznan University of Medical Sciences, Poznań, Poland

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Jan Musiałkiewicz Department of Endocrinology, Metabolism and Internal Diseases, Poznan University of Medical Sciences, Poznań, Poland

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Maja Cieślewicz Department of Endocrinology, Metabolism and Internal Diseases, Poznan University of Medical Sciences, Poznań, Poland

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Adam Maciejewski Department of Endocrinology, Metabolism and Internal Diseases, Poznan University of Medical Sciences, Poznań, Poland

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Prachi Patel Department of Endocrinology, Metabolism and Internal Diseases, Poznan University of Medical Sciences, Poznań, Poland

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George Mastorakos Unit of Endocrinology, Diabetes Mellitus and Metabolism, Aretaieion University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece

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Marek Ruchała Department of Endocrinology, Metabolism and Internal Diseases, Poznan University of Medical Sciences, Poznań, Poland

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in NETs. Patients and methods Patients, inclusion and exclusion criteria We have retrospectively analyzed an institutional database of patients diagnosed with midgut NET and treated with long-acting somatostatin analogs (octreotide

Article Type:
Research Article
Collections:
Cardiovascular
DOI:
https://doi.org/10.1530/EC-23-0249
Volume/Issue:
Volume 12: Issue 10
Open access
Irvin M Modlin Wren Laboratories, Yale University School of Medicine, 35 NE Industrial Road, Branford, Connecticut, USA

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Harry Aslanian Wren Laboratories, Yale University School of Medicine, 35 NE Industrial Road, Branford, Connecticut, USA

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Lisa Bodei Wren Laboratories, Yale University School of Medicine, 35 NE Industrial Road, Branford, Connecticut, USA
Wren Laboratories, Yale University School of Medicine, 35 NE Industrial Road, Branford, Connecticut, USA

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Ignat Drozdov Wren Laboratories, Yale University School of Medicine, 35 NE Industrial Road, Branford, Connecticut, USA

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Mark Kidd Wren Laboratories, Yale University School of Medicine, 35 NE Industrial Road, Branford, Connecticut, USA

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. Disease was localized in 28% and was distant in 67%. No pathology and staging was available in 12 (10%) patients. Twenty-two percent were treatment naïve, while 26% were currently being treated with somatostatin analogs, and 9% (11 patients, all Zollinger

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-14-0100
Volume/Issue:
Volume 3: Issue 4
Open access
Caiyan Mo Department of Endocrinology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

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Tao Tong Department of Endocrinology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

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Ying Guo Department of Endocrinology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

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Zheng Li Department of Endocrinology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

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Liyong Zhong Department of Endocrinology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

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factor 1; M, man; SSA, somatostatin analog; TRAb, thyroid-stimulating hormone receptor antibodies; TSH, thyroid-stimulating hormone; TSS, transsphenoidal surgery; TT3, total triiodothyronine; TT4, total thyroxine;. Among the included patients

Article Type:
Research Article
Collections:
Thyroid
DOI:
https://doi.org/10.1530/EC-23-0439
Volume/Issue:
Volume 13: Issue 4
Open access
Sara Storvall Department of Endocrinology, Abdominal Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland

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Helena Leijon Department of Pathology and Huslab, University of Helsinki and Helsinki University Hospital, Helsinki, Finland

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Eeva Ryhänen Department of Endocrinology, Abdominal Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland

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Johanna Louhimo Department of Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland

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Caj Haglund Department of Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland

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Camilla Schalin-Jäntti Department of Endocrinology, Abdominal Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland

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Johanna Arola Department of Pathology and Huslab, University of Helsinki and Helsinki University Hospital, Helsinki, Finland

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in leukocytes, endothelial cells and macrophages ( 19 ). Somatostatin analogs are widely used in the treatment of different neuroendocrine tumors, such as ACTH-producing pituitary adenomas, somatotropinomas and gastropancreatic neuroendocrine

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-19-0260
Volume/Issue:
Volume 8: Issue 8
Open access
Merete Gedde-Dahl
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Espen Thiis-Evensen
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Andreas Myklebust Tjølsen Section of Gastroenterology, University of Oslo School of Medicine, Department of Transplantation Medicine, Oslo University Hospital, Rikshospitalet, Postboks 4953, Nydalen, 0424 Oslo, Norway

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Kjerstin Skrede Mordal
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Morten Vatn
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Deidi S Bergestuen
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.9%) Known remaining tumor 24 (71%) Disease distribution  Local/regional metastases 5/24 (21%)  Distant metastases a 19/24 (79%) Somatostatin analog use 8 (23.5%) Overnight sampling period (h) 8.3 (7

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-12-0077
Volume/Issue:
Volume 2: Issue 1
Open access