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pressure levels. Future studies could address skeletal muscle metabolism including fat oxidation and mitochondrial function, inflammatory markers, or genetic analyses as areas to explain the increased insulin resistance in older women with a history of GDM
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skeletal muscle metabolism, which may explain contradictive results in post therapeutic muscle mass analysis ( 25 ). This study investigated only women, and similar influence of normalization of thyroid function on body composition parameters, including fat
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, hyperglycemia could induce skeletal muscle atrophy via the WWP1/KLF15 axis ( 39 ). SGK1 acts as a guarder of skeletal muscle metabolism, as overexpression of SGK1 reverses muscle atrophy. At least two mechanisms are involved in this process: (1) SGK1 inactivates
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muscle metabolism ( 22 ). In adipose tissues, insulin resistance is reflected as decreased insulin-stimulated glucose uptake and utilization, which is critically dependent on the IRS-1/AKT/GLUT4 signaling pathway ( 21 ). Consistent with these findings
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muscle metabolism in subjects with Klinefelter syndrome cannot be limited to testosterone levels, as other characteristics might be involved, such as the expression and function of the androgen receptor, insulin-like factor 3 (INSL3) and 25-hydroxy
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