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Natalie Rogowski-Lehmann, Aikaterini Geroula, Aleksander Prejbisz, Henri J L M Timmers, Felix Megerle, Mercedes Robledo, Martin Fassnacht, Stephanie M J Fliedner, Martin Reincke, Anthony Stell, Andrzej Januszewicz, Jacques W M Lenders, Graeme Eisenhofer and Felix Beuschlein

PPGLs are caused by the excessive production of catecholamines and include headache, palpitations and sweating together with intermittently or persistently elevated blood pressure ( 5 ). While the presence of typical signs and symptoms has some

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Wiebke Arlt and the Society for Endocrinology Clinical Committee

higher risk of adrenal crisis. Clinical presentation Clinical signs and symptoms : Fatigue, lack of energy, weight loss Low blood pressure, postural dizziness and hypotension (≥20 mmHg drop in BP from supine to standing position), dizziness

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A Al-Sharefi, P Perros and R A James

, palpitations and sweats is highly suggestive of PHAEO, the condition is still regarded ‘the great mimic’ as the clinical presentation can be diverse with non-specific signs and symptoms ( 19 ). We found that almost half of patients (36/73) did not report any of

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Amir Bashkin, Eliran Yaakobi, Marina Nodelman and Ohad Ronen

most cases, signs and symptoms alone do not signal thyroid dysfunction, except in serious disorders. In our medical center protocol, all patients admitted to the internal medicine departments are routinely screened for TSH levels. The purpose of this

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Ali Abbara, Sophie Clarke, Pei Chia Eng, James Milburn, Devavrata Joshi, Alexander N Comninos, Rozana Ramli, Amrish Mehta, Brynmor Jones, Florian Wernig, Ramesh Nair, Nigel Mendoza, Amir H Sam, Emma Hatfield, Karim Meeran, Waljit S Dhillo and Niamh M Martin

were assessed. The clinical features of pituitary apoplexy assessed in this study relied upon documentation by the admitting physicians of signs and symptoms. Where clinical features were not clearly documented as either being present or absent, these

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Veronica Kieffer, Kate Davies, Christine Gibson, Morag Middleton, Jean Munday, Shashana Shalet, Lisa Shepherd and Phillip Yeoh

• Is able to explain Cushing's disease, Cushing's syndrome and cyclical Cushing's to a patient in simple terms, including signs and symptoms, investigations, and possible treatment options • Provides disease-specific education to the patient regarding

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Nella Augusta Greggio, Elisa Rossi, Silvia Calabria, Alice Meneghin, Joaquin Gutierrez de Rubalcava, Carlo Piccinni and Antonella Pedrini

its range. Signs and symptoms of SH are absent; sometimes the slight symptoms of hypothyroidism are evident. The clinical significance of this mild hyperthyrotropynemia is uncertain; therefore, the debate about the appropriateness of treatment and

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Julie M Silverstein

the management of acromegaly (1) . The overall therapeutic goals include improving control of GH and IGF1 levels, decreasing tumor volume, improving signs and symptoms of the disease, lowering mortality risk, and managing comorbidities (1, 15) . The

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Adrian F Daly, Liliya Rostomyan, Daniela Betea, Jean-François Bonneville, Chiara Villa, Natalia S Pellegata, Beatrice Waser, Jean-Claude Reubi, Catherine Waeber Stephan, Emanuel Christ and Albert Beckers

-generation somatostatin analogs and began pasireotide LAR 30 mg/month as part of a research study. Following up-titration to 60 mg, monthly GH and IGF-1 levels were normalized and the patient reported improvement in clinical signs and symptoms of acromegaly ( Fig. 2

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Efstratios Kardalas, Stavroula A Paschou, Panagiotis Anagnostis, Giovanna Muscogiuri, Gerasimos Siasos and Andromachi Vryonidou

circulating levels of GCs, mineralocorticoids and androgens. This syndrome is inherited as an autosomal recessive or dominant disease. Several rare mutations of the GR gene (NR3C1) have been described, which were associated with clinical signs and symptoms of