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Emmi Naskali Department of Dermatology, Allergology and Venereology, University of Helsinki, and Helsinki University Central Hospital, Helsinki, Finland

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Katja Dettmer Institute of Functional Genomics, University of Regensburg, Regensburg, Germany

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Peter J Oefner Institute of Functional Genomics, University of Regensburg, Regensburg, Germany

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Pedro A B Pereira Institute of Biotechnology, DNA Sequencing and Genomics Laboratory, University of Helsinki, Helsinki, Finland

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Kai Krohn Clinical Research Institute HUCH Ltd, Biomedicum Helsinki 1, Helsinki, Finland

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Petri Auvinen Institute of Biotechnology, DNA Sequencing and Genomics Laboratory, University of Helsinki, Helsinki, Finland

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Annamari Ranki Department of Dermatology, Allergology and Venereology, University of Helsinki, and Helsinki University Central Hospital, Helsinki, Finland

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Nicolas Kluger Department of Dermatology, Allergology and Venereology, University of Helsinki, and Helsinki University Central Hospital, Helsinki, Finland

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of the gastrointestinal (GI) tract ( 9 , 10 ). Serotonin (5-hydroxytryptamine, 5-HT) is synthesized mainly (95%) by GI EE cells and in smaller amounts in the central nervous system ( 11 ). Its synthesis is derived from tryptophan (Trp) in a two

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-18-0513
Volume/Issue:
Volume 8: Issue 1
Open access
Anela Blažević Department of Internal Medicine, Section Endocrinology, Erasmus University Medical Center and Erasmus MC Cancer Institute, Rotterdam, Netherlands

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Anand M Iyer Department of Internal Medicine, Section Endocrinology, Erasmus University Medical Center and Erasmus MC Cancer Institute, Rotterdam, Netherlands

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Marie-Louise F van Velthuysen Department of Pathology, Erasmus University Medical Center and Erasmus MC Cancer Institute, Rotterdam, Netherlands

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Johannes Hofland Department of Internal Medicine, Section Endocrinology, Erasmus University Medical Center and Erasmus MC Cancer Institute, Rotterdam, Netherlands

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Peter M van Koestveld Department of Internal Medicine, Section Endocrinology, Erasmus University Medical Center and Erasmus MC Cancer Institute, Rotterdam, Netherlands

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Gaston J H Franssen Department of Surgery, Erasmus University Medical Center and Erasmus MC Cancer Institute, Rotterdam, Netherlands

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Richard A Feelders Department of Internal Medicine, Section Endocrinology, Erasmus University Medical Center and Erasmus MC Cancer Institute, Rotterdam, Netherlands

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Marina Zajec Laboratory of Neuro-Oncology/Clinical & Cancer Proteomics, Department of Neurology, Erasmus University Medical Center and Erasmus MC Cancer Institute, Rotterdam, Netherlands

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Theo M Luider Laboratory of Neuro-Oncology/Clinical & Cancer Proteomics, Department of Neurology, Erasmus University Medical Center and Erasmus MC Cancer Institute, Rotterdam, Netherlands

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Wouter W de Herder Department of Internal Medicine, Section Endocrinology, Erasmus University Medical Center and Erasmus MC Cancer Institute, Rotterdam, Netherlands

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Leo J Hofland Department of Internal Medicine, Section Endocrinology, Erasmus University Medical Center and Erasmus MC Cancer Institute, Rotterdam, Netherlands

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well established that SI-NETs secrete a wide array of bioactive molecules, with a central role for the bioamine serotonin ( 2 , 3 ). Serotonin signaling is involved in various biological processes. Importantly, it can promote fibrosis development in

Article Type:
Research Article
Collections:
Hormones and Cancer
DOI:
https://doi.org/10.1530/EC-22-0020
Volume/Issue:
Volume 11: Issue 4
Open access
Kylie D Rock Department of Biological Sciences, North Carolina State University, Raleigh, North Carolina, USA

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Brian Horman Department of Biological Sciences, North Carolina State University, Raleigh, North Carolina, USA

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Allison L Phillips Nicholas School of the Environment, Duke University, Durham, North Carolina, USA

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Susan L McRitchie NIH Eastern Regional Comprehensive Metabolomics Res. Core, Univ. of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

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Scott Watson NIH Eastern Regional Comprehensive Metabolomics Res. Core, Univ. of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

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Jocelin Deese-Spruill NIH Eastern Regional Comprehensive Metabolomics Res. Core, Univ. of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

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Dereje Jima Center for Human Health and the Environment, North Carolina State University, Raleigh, North Carolina, USA
Bioinformatics Research Center, North Carolina State University, Raleigh, North Carolina, USA

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Susan Sumner NIH Eastern Regional Comprehensive Metabolomics Res. Core, Univ. of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Center for Human Health and the Environment, North Carolina State University, Raleigh, North Carolina, USA

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Heather M Stapleton Nicholas School of the Environment, Duke University, Durham, North Carolina, USA

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Heather B Patisaul Department of Biological Sciences, North Carolina State University, Raleigh, North Carolina, USA
Center for Human Health and the Environment, North Carolina State University, Raleigh, North Carolina, USA

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proliferation and migration, myelination and differentiation ( 86 , 87 ). That placental norepinephrine levels were reduced in low-dose females is also of interest given that gestational exposure to serotonin-norepinephrine reuptake inhibitors (SNRIs) can

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-17-0373
Volume/Issue:
Volume 7: Issue 2
Open access
Jean-Benoît Corcuff Department of Nuclear Medicine, Haut Lévêque Hospital, Pessac, France
Nutrition et Neurobiologie intégrée, UMR 1286, University of Bordeaux, Bordeaux, France
Groupe de Biologie Spécialisée, Société Française de Médecine Nucléaire, Paris, France

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Laurence Chardon Department of Biochemistry, Edouard Herriot Hospital, Lyon, France

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Ines El Hajji Ridah Biomnis, Lyon, France

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Julie Brossaud Department of Nuclear Medicine, Haut Lévêque Hospital, Pessac, France
Nutrition et Neurobiologie intégrée, UMR 1286, University of Bordeaux, Bordeaux, France
Groupe de Biologie Spécialisée, Société Française de Médecine Nucléaire, Paris, France

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not discuss the level of diagnosis performed to quantify these analytes as this was covered in many publications. Urinary metabolite of serotonin, 5 hydroxy-indole acetic acid Because neuroendocrine cells may secrete serotonin, its main

Article Type:
Review Article
DOI:
https://doi.org/10.1530/EC-17-0071
Volume/Issue:
Volume 6: Issue 6
Open access
Merete Gedde-Dahl
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Espen Thiis-Evensen
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Andreas Myklebust Tjølsen Section of Gastroenterology, University of Oslo School of Medicine, Department of Transplantation Medicine, Oslo University Hospital, Rikshospitalet, Postboks 4953, Nydalen, 0424 Oslo, Norway

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Kjerstin Skrede Mordal
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Morten Vatn
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Deidi S Bergestuen
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exclusively seen in patients with liver metastases, or metastases outside the abdominal cavity, as serotonin and other secretory products from the primary tumor are metabolized in the liver at first pass. Reportedly, 10–18% of patients with small intestinal

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-12-0077
Volume/Issue:
Volume 2: Issue 1
Open access
Irasema Mendieta Facultad de Química, Universidad Autónoma de Querétaro, Querétaro, Mexico

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Rosa Elvira Nuñez-Anita Facultad de Medicina Veterinaria y Zootecnia, Universidad Michoacana de San Nicolás Hidalgo, Morelia, Michoacán, Mexico

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Gilberto Pérez-Sánchez Departmento de Psicoimunología, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Ciudad de México, Mexico

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Lenin Pavón Departmento de Psicoimunología, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Ciudad de México, Mexico

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Alfredo Rodríguez-Cruz Facultad de Química, Universidad Autónoma de Querétaro, Querétaro, Mexico

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Guadalupe García-Alcocer Facultad de Química, Universidad Autónoma de Querétaro, Querétaro, Mexico

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Laura Cristina Berumen Facultad de Química, Universidad Autónoma de Querétaro, Querétaro, Mexico

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-methylxanthine (I7018), forskolin (F6886) and serotonin (H9523) were purchased from Sigma-Aldrich. All other chemicals were of the highest grade of purity commercially available. Cell culture A549/GFP cells and co-cultures were maintained in DMEM, and

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-18-0145
Volume/Issue:
Volume 7: Issue 5
Open access
Kjell Oberg Uppsala University, Uppsala, Sweden

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Eric Krenning Erasmus Medical Center, Rotterdam, Netherlands

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Anders Sundin Uppsala University, Uppsala, Sweden

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Lisa Bodei Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Mark Kidd Wren Laboratories, Branford, Connecticut, USA

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Margot Tesselaar Netherlands Cancer Institute, Amsterdam, Netherlands

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Valentina Ambrosini University of Bologna, Bologna, Italy

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Richard P Baum Zentralklinik Bad Berka, Bad Berka, Germany

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Matthew Kulke Dana Farber Cancer Institute, Boston, Massachusetts, USA

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Marianne Pavel Charite Hospital, Berlin, Germany

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Jaroslaw Cwikla University of Warmia and Mazury, Olsztyn, Poland

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Ignat Drozdov Wren Laboratories, Branford, Connecticut, USA

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Massimo Falconi Ospedale San Raffaele, Milan, Italy

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Nicola Fazio IEO (European Institute of Oncology), Milan, Italy

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Andrea Frilling Imperial College London, London, UK

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Robert Jensen National Institutes of Health, Bethesda, Maryland, USA

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Klaus Koopmans Martini Ziekenhuis, Groningen, Netherlands

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Tiny Korse Netherlands Cancer Institute, Amsterdam, Netherlands

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Dik Kwekkeboom Erasmus Medical Center, Rotterdam, Netherlands

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Helmut Maecke University Hospital Freiburg, Freiburg, Germany

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Giovanni Paganelli Instituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Meldola, Italy

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Ramon Salazar Instituto Catala d’Oncologia, Barcelona, Spain

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Stefano Severi Instituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Meldola, Italy

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Jonathan Strosberg H. Lee Moffitt Cancer Center, Tampa, Florida, USA

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Vikas Prasad Charite Hospital, Berlin, Germany

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Aldo Scarpa University of Verona, Verona, Italy

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Ashley Grossman Univeristy of Oxford, Oxford, UK

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Annemeik Walenkamp University of Groningen, Groningen, Netherlands

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Mauro Cives H. Lee Moffitt Cancer Center, Tampa, Florida, USA

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Irene Virgolini Medical University Innsbruck, Innsbruck, Austria

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Andreas Kjaer Copenhagen University, Copenhagen, Denmark

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Irvin M Modlin Yale University, New Haven, Connecticut, USA

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(5-HIAA; in serotonin-secreting tumors) have been used in this capacity ( 29 ). Secretory (monoanalyte) biomarkers for specific tumor types (insulinoma: insulin, gastrinoma: gastrin, glucagonoma: glucagon and VIPoma: VIP) are effective serum

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-16-0043
Volume/Issue:
Volume 5: Issue 5
Open access
Matilde Calanchini Oxford Centre for Diabetes, Endocrinology & Metabolism, Churchill Hospital, University of Oxford, Oxford, UK
Endocrinology & Metabolism Unit, CTO A. Alesini Hospital ASL Roma 2, Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy

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Michael Tadman Oxford Centre for Diabetes, Endocrinology & Metabolism, Churchill Hospital, University of Oxford, Oxford, UK

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Jesper Krogh Oxford Centre for Diabetes, Endocrinology & Metabolism, Churchill Hospital, University of Oxford, Oxford, UK

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Andrea Fabbri Endocrinology & Metabolism Unit, CTO A. Alesini Hospital ASL Roma 2, Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy

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Ashley Grossman Oxford Centre for Diabetes, Endocrinology & Metabolism, Churchill Hospital, University of Oxford, Oxford, UK

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Brian Shine Oxford Centre for Diabetes, Endocrinology & Metabolism, Churchill Hospital, University of Oxford, Oxford, UK

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mesenteric fibrosis ( 9 , 10 ). Serotonin is one of the most important biomarkers related to the development of CS, mesenteric fibrosis and carcinoid heart disease. Serotonin is produced in large amounts by NEN cells, most commonly in patients with NENs in

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-19-0269
Volume/Issue:
Volume 8: Issue 8
Open access
Paweł Komarnicki Department of Endocrinology, Metabolism and Internal Diseases, Poznan University of Medical Sciences, Poznań, Poland

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Paweł Gut Department of Endocrinology, Metabolism and Internal Diseases, Poznan University of Medical Sciences, Poznań, Poland

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Jan Musiałkiewicz Department of Endocrinology, Metabolism and Internal Diseases, Poznan University of Medical Sciences, Poznań, Poland

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Maja Cieślewicz Department of Endocrinology, Metabolism and Internal Diseases, Poznan University of Medical Sciences, Poznań, Poland

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Adam Maciejewski Department of Endocrinology, Metabolism and Internal Diseases, Poznan University of Medical Sciences, Poznań, Poland

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Prachi Patel Department of Endocrinology, Metabolism and Internal Diseases, Poznan University of Medical Sciences, Poznań, Poland

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George Mastorakos Unit of Endocrinology, Diabetes Mellitus and Metabolism, Aretaieion University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece

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Marek Ruchała Department of Endocrinology, Metabolism and Internal Diseases, Poznan University of Medical Sciences, Poznań, Poland

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). Carcinoid syndrome (CS) is characterized by increased secretion of serotonin, and other biogenic amines and peptides. It manifests as a set of symptoms including diarrhea, skin flushing, and abdominal pain ( 15 ). Patients with liver metastases frequently

Article Type:
Research Article
Collections:
Cardiovascular
DOI:
https://doi.org/10.1530/EC-23-0249
Volume/Issue:
Volume 12: Issue 10
Open access
Dorte Glintborg Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark

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Magda Lambaa Altinok Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark

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Pernille Ravn Department of Gynecology and Obstetrics, Odense University Hospital, Odense, Denmark

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Kurt Bjerregaard Stage Department of Psychiatry, Odense University Hospital, Odense, Denmark

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Kurt Højlund Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark

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Marianne Andersen Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark

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in PCOS could be associated with increased HPA activity ( 11 ). Treatment with specific serotonin reuptake inhibitor (SSRI) is the first choice for depression and 16.3% Danish women with PCOS had prescriptions of antidepressants ( 6 ). The possible

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-18-0077
Volume/Issue:
Volume 7: Issue 3
Open access