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Emmi Naskali, Katja Dettmer, Peter J Oefner, Pedro A B Pereira, Kai Krohn, Petri Auvinen, Annamari Ranki and Nicolas Kluger

of the gastrointestinal (GI) tract ( 9 , 10 ). Serotonin (5-hydroxytryptamine, 5-HT) is synthesized mainly (95%) by GI EE cells and in smaller amounts in the central nervous system ( 11 ). Its synthesis is derived from tryptophan (Trp) in a two

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Kylie D Rock, Brian Horman, Allison L Phillips, Susan L McRitchie, Scott Watson, Jocelin Deese-Spruill, Dereje Jima, Susan Sumner, Heather M Stapleton and Heather B Patisaul

proliferation and migration, myelination and differentiation ( 86 , 87 ). That placental norepinephrine levels were reduced in low-dose females is also of interest given that gestational exposure to serotonin-norepinephrine reuptake inhibitors (SNRIs) can

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Jean-Benoît Corcuff, Laurence Chardon, Ines El Hajji Ridah and Julie Brossaud

not discuss the level of diagnosis performed to quantify these analytes as this was covered in many publications. Urinary metabolite of serotonin, 5 hydroxy-indole acetic acid Because neuroendocrine cells may secrete serotonin, its main

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Merete Gedde-Dahl, Espen Thiis-Evensen, Andreas Myklebust Tjølsen, Kjerstin Skrede Mordal, Morten Vatn and Deidi S Bergestuen

exclusively seen in patients with liver metastases, or metastases outside the abdominal cavity, as serotonin and other secretory products from the primary tumor are metabolized in the liver at first pass. Reportedly, 10–18% of patients with small intestinal

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Irasema Mendieta, Rosa Elvira Nuñez-Anita, Gilberto Pérez-Sánchez, Lenin Pavón, Alfredo Rodríguez-Cruz, Guadalupe García-Alcocer and Laura Cristina Berumen

-methylxanthine (I7018), forskolin (F6886) and serotonin (H9523) were purchased from Sigma-Aldrich. All other chemicals were of the highest grade of purity commercially available. Cell culture A549/GFP cells and co-cultures were maintained in DMEM, and

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Kjell Oberg, Eric Krenning, Anders Sundin, Lisa Bodei, Mark Kidd, Margot Tesselaar, Valentina Ambrosini, Richard P Baum, Matthew Kulke, Marianne Pavel, Jaroslaw Cwikla, Ignat Drozdov, Massimo Falconi, Nicola Fazio, Andrea Frilling, Robert Jensen, Klaus Koopmans, Tiny Korse, Dik Kwekkeboom, Helmut Maecke, Giovanni Paganelli, Ramon Salazar, Stefano Severi, Jonathan Strosberg, Vikas Prasad, Aldo Scarpa, Ashley Grossman, Annemeik Walenkamp, Mauro Cives, Irene Virgolini, Andreas Kjaer and Irvin M Modlin

(5-HIAA; in serotonin-secreting tumors) have been used in this capacity ( 29 ). Secretory (monoanalyte) biomarkers for specific tumor types (insulinoma: insulin, gastrinoma: gastrin, glucagonoma: glucagon and VIPoma: VIP) are effective serum

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Matilde Calanchini, Michael Tadman, Jesper Krogh, Andrea Fabbri, Ashley Grossman and Brian Shine

mesenteric fibrosis ( 9 , 10 ). Serotonin is one of the most important biomarkers related to the development of CS, mesenteric fibrosis and carcinoid heart disease. Serotonin is produced in large amounts by NEN cells, most commonly in patients with NENs in

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Dorte Glintborg, Magda Lambaa Altinok, Pernille Ravn, Kurt Bjerregaard Stage, Kurt Højlund and Marianne Andersen

in PCOS could be associated with increased HPA activity ( 11 ). Treatment with specific serotonin reuptake inhibitor (SSRI) is the first choice for depression and 16.3% Danish women with PCOS had prescriptions of antidepressants ( 6 ). The possible

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Irvin M Modlin, Harry Aslanian, Lisa Bodei, Ignat Drozdov and Mark Kidd

cell tumors), as well as small intestinal ‘carcinoids’ (secretin, serotonin, and a variety of tachykinins) and colorectal lesions (enteroglucagon, GLP1, and pancreatic polypeptide (PP)). The conundrum of identifying a global marker for NETs therefore

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Myrtille Fouché, Yves Bouffard, Mary-Charlotte Le Goff, Johanne Prothet, François Malavieille, Pierre Sagnard, Françoise Christin, Davy Hayi-Slayman, Arnaud Pasquer, Gilles Poncet, Thomas Walter and Thomas Rimmelé

Introduction Small-bowel neuroendocrine tumours (SB-NETs) are rare secreting neoplasms. Hormones (serotonin, histamine, bradykinin, prostaglandins and chromogranin-A) released into the systemic circulation can lead to a carcinoid syndrome (CS