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Marloes L P Langelaan Clinical Laboratory, Catharina Hospital Eindhoven, Eindhoven, The Netherlands
Department of Clinical Chemistry and Haematology, Zuyderland Medical Centre, Heerlen, The Netherlands

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Jérôme M H Kisters Department of Internal Medicine, Catharina Hospital Eindhoven, Eindhoven, The Netherlands

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Mirjam M Oosterwerff Department of Internal Medicine, Catharina Hospital Eindhoven, Eindhoven, The Netherlands

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Arjen-Kars Boer Clinical Laboratory, Catharina Hospital Eindhoven, Eindhoven, The Netherlands

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Introduction The utility of measuring salivary cortisol has become increasingly popular in, for example, screening for Cushing’s syndrome or disease ( 1 , 2 ). Obtaining salivary samples is easy and patient friendly. An additional advantage

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-18-0085
Volume/Issue:
Volume 7: Issue 4
Open access
Karim Gariani Service of Endocrinology, Diabetes, Hypertension and Nutrition, Geneva University Hospitals, Geneva, Switzerland

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Pedro Marques-Vidal Departments of Medicine and Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland

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Gérard Waeber Departments of Medicine and Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland

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Peter Vollenweider Departments of Medicine and Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland

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François R Jornayvaz Service of Endocrinology, Diabetes, Hypertension and Nutrition, Geneva University Hospitals, Geneva, Switzerland

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associated with IR and cardiovascular risk factors ( 13 ). Several studies have shown that individuals with glucose intolerance or T2DM exhibit a significantly higher level of chronic stress and hormonal stress responses ( 14 , 15 ). Salivary cortisol has

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-19-0251
Volume/Issue:
Volume 8: Issue 7
Open access
Marcus Imamovic Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden

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Nils Bäcklund Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden

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Staffan Lundstedt Department of Medical Biosciences, Umeå University, Umeå, Sweden

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Göran Brattsand Department of Medical Biosciences, Umeå University, Umeå, Sweden

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Elisabeth Aardal Department of Clinical Chemistry and Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden

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Tommy Olsson Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden

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Per Dahlqvist Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden

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Introduction Timely diagnosis of endogenous Cushing's syndrome (CS) is important to reduce morbidity and mortality ( 1 , 2 , 3 ). Late-night salivary cortisol (LNSC) is an important screening instrument for CS with high sensitivity and

Article Type:
Research Article
Collections:
Adrenal
DOI:
https://doi.org/10.1530/EC-22-0324
Volume/Issue:
Volume 12: Issue 1
Open access
Filippo Ceccato Endocrinology Unit, Department of Medicine DIMED, University-Hospital of Padova, Padova, Italy

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Elisa Selmin Endocrinology Unit, Department of Medicine DIMED, University-Hospital of Padova, Padova, Italy

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Chiara Sabbadin Endocrinology Unit, Department of Medicine DIMED, University-Hospital of Padova, Padova, Italy

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Miriam Dalla Costa Endocrinology Unit, Department of Medicine DIMED, University-Hospital of Padova, Padova, Italy

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Giorgia Antonelli Laboratory Medicine, Department of Medicine DIMED, University-Hospital of Padova, Padova, Italy

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Mario Plebani Laboratory Medicine, Department of Medicine DIMED, University-Hospital of Padova, Padova, Italy

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Mattia Barbot Endocrinology Unit, Department of Medicine DIMED, University-Hospital of Padova, Padova, Italy

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Corrado Betterle Endocrinology Unit, Department of Medicine DIMED, University-Hospital of Padova, Padova, Italy

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Marco Boscaro Endocrinology Unit, Department of Medicine DIMED, University-Hospital of Padova, Padova, Italy

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Carla Scaroni Endocrinology Unit, Department of Medicine DIMED, University-Hospital of Padova, Padova, Italy

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-HC (conv-HC) ( 10 , 11 , 12 ). AI treatment is further complicated by the absence of a universally accepted method to objectively evaluate the adequacy of GC substitutive therapy. We had recently proposed multiple salivary cortisol (F) collections to

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-18-0257
Volume/Issue:
Volume 7: Issue 9
Open access
Sarah Ying Tse Tan Department of Endocrinology, Singapore General Hospital, Singapore

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Hong Chang Tan Department of Endocrinology, Singapore General Hospital, Singapore

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Ling Zhu Department of Endocrinology, Singapore General Hospital, Singapore

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Lih Ming Loh Department of Endocrinology, Singapore General Hospital, Singapore

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Dawn Shao Ting Lim Department of Endocrinology, Singapore General Hospital, Singapore

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Du Soon Swee Department of Endocrinology, Singapore General Hospital, Singapore

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Yoke Ling Chan Department of Speciality Nursing, Singapore General Hospital, Singapore

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Huee Boon Lim Department of Speciality Nursing, Singapore General Hospital, Singapore

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Shiau Lee Ling Department of Speciality Nursing, Singapore General Hospital, Singapore

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En Jun Ou Department of Speciality Nursing, Singapore General Hospital, Singapore

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Wynn Ee Teo Department of Speciality Nursing, Singapore General Hospital, Singapore

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Xiao Ping Zhang Department of Speciality Nursing, Singapore General Hospital, Singapore

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Hui Fen Goh Department of Speciality Nursing, Singapore General Hospital, Singapore

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Peng Chin Kek Department of Endocrinology, Singapore General Hospital, Singapore

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, and calculations of the free cortisol index are limited by the measurement of cortisol-binding globulin and do not account for changes in binding affinity or albumin concentrations ( 12 , 13 ). Salivary cortisol is an alternative method to measure

Article Type:
Research Article
Collections:
Adrenal
DOI:
https://doi.org/10.1530/EC-23-0004
Volume/Issue:
Volume 12: Issue 4
Open access
Ramjan Sanas Mohamed Department of Endocrinology, Imperial College Healthcare NHS Trust, London, UK

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Biyaser Abuelgasim Imperial College School of Medicine, Department of Biochemistry, Imperial College Healthcare NHS Trust, London, UK

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Sally Barker Imperial College School of Medicine, Department of Biochemistry, Imperial College Healthcare NHS Trust, London, UK

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Hemanth Prabhudev Department of Endocrinology, Imperial College Healthcare NHS Trust, London, UK

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Niamh M Martin Department of Endocrinology, Imperial College Healthcare NHS Trust, London, UK
Division of Diabetes, Endocrinology and Metabolism, Imperial College London, London, UK

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Karim Meeran Department of Endocrinology, Imperial College Healthcare NHS Trust, London, UK
Division of Diabetes, Endocrinology and Metabolism, Imperial College London, London, UK

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Emma L Williams Department of Biochemistry, Imperial College Healthcare NHS Trust, London, UK

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Sarah Darch Department of Biochemistry, Imperial College Healthcare NHS Trust, London, UK

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Whitlock Matthew Department of Biochemistry, Imperial College Healthcare NHS Trust, London, UK

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Tricia Tan Department of Endocrinology, Imperial College Healthcare NHS Trust, London, UK
Division of Diabetes, Endocrinology and Metabolism, Imperial College London, London, UK

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Florian Wernig Department of Endocrinology, Imperial College Healthcare NHS Trust, London, UK

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for CS including late-night salivary cortisol (LNSC), overnight dexamethasone suppression test (ODST), low-dose dexamethasone suppression test (LDDST) and 24-h urinary free cortisol (UFC) ( 1 , 2 , 3 ). A hallmark of CS is the disruption of the

Article Type:
Research Article
Collections:
Adrenal
DOI:
https://doi.org/10.1530/EC-22-0050
Volume/Issue:
Volume 11: Issue 7
Open access
Filippo Ceccato Department of Medicine DIMED, University of Padova, Padova, Italy
Endocrine Disease Unit, University-Hospital of Padova, Padova, Italy
Department of Neuroscience DNS, University of Padova, Padova, Italy

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Elisa Selmin Department of Medicine DIMED, University of Padova, Padova, Italy

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Giorgia Antonelli Department of Medicine DIMED, University of Padova, Padova, Italy
Laboratory Medicine, University-Hospital of Padova, Padova, Italy

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Mattia Barbot Department of Medicine DIMED, University of Padova, Padova, Italy
Endocrine Disease Unit, University-Hospital of Padova, Padova, Italy
Department of Neuroscience DNS, University of Padova, Padova, Italy

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Andrea Daniele Department of Medicine DIMED, University of Padova, Padova, Italy

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Marco Boscaro Department of Medicine DIMED, University of Padova, Padova, Italy

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Mario Plebani Department of Medicine DIMED, University of Padova, Padova, Italy
Laboratory Medicine, University-Hospital of Padova, Padova, Italy

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Carla Scaroni Department of Medicine DIMED, University of Padova, Padova, Italy
Endocrine Disease Unit, University-Hospital of Padova, Padova, Italy

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. Table 1 Basal and post-synacthen serum or salivary cortisol (F) and cortisone (E) levels. Data are expressed as means and s.e. Adrenal sufficient patients, n = 137 Central AI, n = 37 Normal HPA axis, n = 106 RAS, n

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-21-0404
Volume/Issue:
Volume 10: Issue 9
Open access
Hershel Raff Division of Endocrinology, Division of Nephrology, Endocrine Research Laboratory, Department of Medicine
Division of Endocrinology, Division of Nephrology, Endocrine Research Laboratory, Department of Medicine
Division of Endocrinology, Division of Nephrology, Endocrine Research Laboratory, Department of Medicine
Division of Endocrinology, Division of Nephrology, Endocrine Research Laboratory, Department of Medicine

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Hariprasad Trivedi Division of Endocrinology, Division of Nephrology, Endocrine Research Laboratory, Department of Medicine

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Introduction The measurement of salivary cortisol has emerged as a first-line test in the evaluation of the hypothalamic–pituitary–adrenal (HPA) axis in humans and, in particular, for the diagnosis of endogenous hypercortisolism (Cushing

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-12-0058
Volume/Issue:
Volume 2: Issue 1
Open access
Eva Olga Melin Diabetes Research Laboratory, Lund University, Lund, Sweden
Department of Research and Development, Region Kronoberg, Växjö, Sweden

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Magnus Hillman Diabetes Research Laboratory, Lund University, Lund, Sweden

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Mona Landin-Olsson Diabetes Research Laboratory, Lund University, Lund, Sweden
Department of Endocrinology, Skane University Hospital, Lund, Sweden

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with high midnight salivary cortisol (MSC) secretion (≥9.3 nmol/L) in these patients with T1D ( 22 ). We hypothesise that high MSC secretion contributes to hypertension and to treatment failure of antihypertensive drugs (AHDs). The main aims were to

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-19-0407
Volume/Issue:
Volume 8: Issue 11
Open access
S U Jayasinghe
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S J Torres
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C A Nowson
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A J Tilbrook Centre for Physical Activity and Nutrition Research, Livestock and Farming Systems, School of Exercise and Nutrition Sciences, Deakin University, Burwood, Melbourne, Victoria 3125, Australia

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A I Turner
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salivary alpha amylase and HR responses to the TSST. It was hypothesised that overweight/obese men aged 50–70 years will have a greater salivary cortisol, salivary alpha amylase and HR response to the TSST compared with age matched lean men. Subjects and

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-14-0042
Volume/Issue:
Volume 3: Issue 3
Open access