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Ermina Bach, Niels Møller, Jens Otto L Jørgensen, Mads Buhl and Holger Jon Møller

Introduction CD163 is a cortisol-regulated monocyte and macrophage-specific surface glycoprotein and the extracellular portion of CD163 circulates in blood as a soluble protein (sCD163) ( 1 ). sCD163 is highly elevated in acute infections

Open access

Henrik H Thomsen, Holger J Møller, Christian Trolle, Kristian A Groth, Anne Skakkebæk, Anders Bojesen, Christian Høst and Claus H Gravholt

granulocyte–macrophage colony-stimulating factor (2, 3) . A soluble form of CD163 (sCD163) is formed by proteolytic cleavage of the extracellular part of the protein and shed into circulation (1, 2) . The function of sCD163 is not clear; however, a role in

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Nikolaj Rittig, Mads Svart, Niels Jessen, Niels Møller, Holger J Møller and Henning Grønbæk

Introduction Macrophage activation is considered an important part of the pathogenesis of several diseases. Hence, the macrophage activation marker-soluble CD163 (sCD163) is of high interest and has already been associated with diseases such

Open access

Eva O Melin, Jonatan Dereke, Maria Thunander and Magnus Hillman

infections, and it was shown that interaction between bacterial structures and CD163 led to an increase of proinflammatory cytokines ( 16 ). The soluble form, sCD163, is shed during inflammation from CD163 by ADAM-17, the same metalloproteinase that sheds TNF

Open access

Lars Peter Sørensen, Tina Parkner, Esben Søndergaard, Bo Martin Bibby, Holger Jon Møller and Søren Nielsen

(TACE) (16) . Recently, it has been demonstrated that TACE is also responsible for the shedding of monocyte/macrophage-specific soluble CD163 (sCD163) (17) . Plasma sCD163 is regarded as a marker of macrophage activity and a long-circulating marker of