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Jeonghoon Ha, Jeongmin Lee, Kwanhoon Jo, Dong-Jun Lim, Moo Il Kang, Bong Yun Cha and Min-Hee Kim

-thyroid peroxidase antibody (TPOAb) or anti-thyroglobulin antibody ( 11 , 12 ). The higher incidence of thyroid autoantibodies in women is reported to account for their higher incidence of thyroid disease ( 9 , 13 ). However, other sex-specific risk factors for SCH

Open access

Sanna Mustaniemi, Marja Vääräsmäki, Johan G Eriksson, Mika Gissler, Hannele Laivuori, Hilkka Ijäs, Aini Bloigu, Eero Kajantie and Laure Morin-Papunen

conditions ( 8 , 9 ). GDM and PCOS can be early signs of an increased risk of manifest diseases related to insulin resistance, such as type 2 diabetes (T2D), and both disorders are also connected with cardiovascular risk factors, such as metabolic syndrome

Open access

Julia Kubiak, Per Medbøe Thorsby, Elena Kamycheva and Rolf Jorde

processes ( 1 ). Low serum 25(OH)D levels have additionally been related to numerous diseases, including cardiovascular disease (CVD) and their risk factors ( 2 ). Thus, a meta-analysis of 19 prospective studies focusing on the relation between vitamin D

Open access

Gunjan Garg, Garima Kachhawa, Rekha Ramot, Rajesh Khadgawat, Nikhil Tandon, V Sreenivas, Alka Kriplani and N Gupta

cardiovascular risk factors in subjects with PCOS. Material and methods Study design This study was conducted as a prospective randomized double-blind placebo controlled study after obtaining approval from the ethics committee of the institute and written

Open access

Karolien Van De Maele, Jean De Schepper, Jesse Vanbesien, Monique Van Helvoirt, Ann De Guchtenaere and Inge Gies

Dahl AR Lteif A Kumar S . Vitamin D deficiency: a potential modifiable risk factor for cardiovascular disease in children with severe obesity . Children 2017 80 . ( ) 6 Mehmood ZH Papandreou D

Open access

Line K Johnson, Kirsten B Holven, Njord Nordstrand, Jan R Mellembakken, Tom Tanbo and Jøran Hjelmesæth

a lower prevalence of cardiometabolic risk factors including MS, cardiovascular inflammation and obesity (15) . Additionally, fiber intake improves gastrointestinal function and may prevent development of colorectal cancer (16) . Fiber intake from

Open access

Wei Sun, Boyuan Zheng, Zhihong Wang, Wenwu Dong, Yuan Qin and Hao Zhang

Background: Papillary thyroid cancer (PTC) patients with clinical negative central lymph nodes (cN0), the use of prophylactic central lymph node dissection remains controversial. Patients with cN0 disease receive contralateral central lymph node metastasis (CCLNM) 3.88–30.63% of cases. Therefore, the present study aimed to obtain evidence for CCLNM risk factors in unilateral cN0 PTC.

Materials and methods: Relevant studies were searched in the PubMed, SCIE, and Wanfang databases up to 31 Oct 2019. The included patients had undergone lobectomy or total thyroidectomy with bilateral central lymph node dissection and were diagnosed pathologically with PTC.

Results: Thirteen studies comprising 2449 patients were included. The factors associated with increased CCLNM risk in cN0 unilateral PTC were: age < 45 years (odds ratio (OR) = 1.89, 95% confidence interval (CI) = 1.43–2.49, P < 0.00001), male sex (OR = 1.67, 95% CI = 1.24–2.24, P = 0.0007), extrathyroidal extension (OR = 1.63; 95% CI = 1.17-2.28; P = 0.004), tumor size ≥ 1 cm (OR = 2.63, 95% CI 1.85–3.74, P < 0.00001), lymphovascular invasion (OR = 4.27, 95% CI =2.47-7.37, P < 0.00001) and ipsilateral CLNM (OR = 11.42, 95% CI = 5.25-24.86, P < 0.00001). However, no association was found for capsular invasion, multifocality and Hashimoto thyroiditis.

Conclusion: The study identified that age <45 years, tumor ≥1 cm, male sex, lymphovascular invasion, extrathyroidal extension and ipsilateral CLNM are related to CCLNM in CN0 PTC. These factors should influence the use of prophylactic central lymph node dissection in these patients.

Open access

Jakob Kirkegård, Dora Körmendiné Farkas, Jens Otto Lunde Jørgensen and Deirdre P Cronin-Fenton

. ( 4 ) who observed a higher incidence of stomach cancer in patients with Hashimoto’s thyroiditis – a subtype of hypothyroidism. As tobacco smoking is a risk factor for both stomach cancer ( 18 ) and Hashimoto’s thyroiditis, confounding by tobacco

Open access

Paolo G Arduino, Dora Karimi, Federico Tirone, Veronica Sciannameo, Fulvio Ricceri, Marco Cabras, Alessio Gambino, Davide Conrotto, Stefano Salzano, Mario Carbone and Roberto Broccoletti

The association between oral lichen planus (OLP) and hypothyroidism has been debated with conflicting results: some authors detected a statistically significant association between these two, while others did not confirm it. The aim of this study was to evaluate the thyroid status in patients with newly diagnosed OLP to test the null hypothesis that thyroid disease is not associated with an increased incidence of oral lesions, with a prospective case-control approach. A total of 549 patients have been evaluated, of whom 355 were female. Odds ratio (OR) and 95% confidence intervals (CIs) were obtained. Patients suffering from thyroid diseases were associated with an almost 3-fold increased odds of having OLP (OR 2.85, 95% CI: 1.65–4.94), after adjusting this analysis for age, gender, body mass index, smoking status, diabetes, hypertension and hepatitis C infection. It would be appropriate to further investigate the possible concomitance of OLP among patients with thyroid disorder; endocrinologists should be aware of this association, especially because OLP is considered a potentially malignant oral disorder.

Open access

N Bergmann, F Gyntelberg and J Faber

Introduction The metabolic syndrome (MES) is a cluster of risk factors including male adiposity, dyslipidemia, reduced glucose tolerance and hypertension. MES is highly prevalent and increasing in most parts of the world (1) . A meta-analysis has