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Shilpa Lingaiah, Laure Morin-Papunen, Terhi Piltonen, Inger Sundström-Poromaa, Elisabet Stener-Victorin and Juha S Tapanainen

pathogenesis of PCOS ( 5 , 6 , 7 ), it is not clear whether they have a direct association with PCOS. Adipose tissue acts as an endocrine organ secreting various adipokines including retinol-binding protein 4 (RBP4), which is mainly synthesised by hepatocytes

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Esben Thyssen Vestergaard, Morten B Krag, Morten M Poulsen, Steen B Pedersen, Niels Moller, Jens Otto Lunde Jorgensen and Niels Jessen

, 12, 13) . The diabetogenic effects of GH are well established (14, 15) , although the exact mechanisms by which GH induces insulin resistance remain to be elucidated. Retinol-binding protein-4 (RBP4) is a protein and its serum levels are increased in