Qiuli Liu
Qiuli Liu
Department of Urology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, People’s Republic of China
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Gang Yuan
Gang Yuan
Department of Urology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, People’s Republic of China
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Dali Tong
Dali Tong
Department of Urology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, People’s Republic of China
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Gaolei Liu
Gaolei Liu
Department of Urology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, People’s Republic of China
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Yuting Yi
Yuting Yi
Geneplus-Beijing Institute, Beijing, People’s Republic of China
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Jun Zhang
Jun Zhang
Department of Urology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, People’s Republic of China
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Yao Zhang
Yao Zhang
Department of Urology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, People’s Republic of China
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Lin-ang Wang
Lin-ang Wang
Department of Urology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, People’s Republic of China
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Luofu Wang
Luofu Wang
Department of Urology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, People’s Republic of China
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Dianzheng Zhang
Dianzheng Zhang
Department of Bio-Medical Sciences, Philadelphia College of Osteopathic Medicine, Philadelphia, Pennsylvania, USA
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Rongrong Chen
Rongrong Chen
Geneplus-Beijing Institute, Beijing, People’s Republic of China
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Yanfang Guan
Yanfang Guan
Geneplus-Beijing Institute, Beijing, People’s Republic of China
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Xin Yi
Xin Yi
Geneplus-Beijing Institute, Beijing, People’s Republic of China
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Weihua Lan
Weihua Lan
Department of Urology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, People’s Republic of China
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Jun Jiang
Jun Jiang
Department of Urology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, People’s Republic of China
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neuroendocrine tumor (NET) or cystadenoma, pheochromocytoma (Pheo) and clear cell renal cell carcinoma (RCC) ( 1 , 2 ). VHL disease is primarily caused by inactivation of the VHL tumor-suppressive protein. A dysfunctional VHL leads to reduced ubiquitylation and
Deborah Cosentini
Deborah Cosentini
Medical Oncology Unit, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, ASST Spedali Civili, Brescia, Italy
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Salvatore Grisanti
Salvatore Grisanti
Medical Oncology Unit, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, ASST Spedali Civili, Brescia, Italy
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Alberto Dalla Volta
Alberto Dalla Volta
Medical Oncology Unit, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, ASST Spedali Civili, Brescia, Italy
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Marta Laganà
Marta Laganà
Medical Oncology Unit, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, ASST Spedali Civili, Brescia, Italy
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Chiara Fiorentini
Chiara Fiorentini
Section of Pharmacology, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy
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Paola Perotti
Paola Perotti
Internal Medicine, Department of Clinical and Biological Sciences, San Luigi Hospital, University of Turin, Orbassano, Italy
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Sandra Sigala
Sandra Sigala
Section of Pharmacology, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy
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Alfredo Berruti
Alfredo Berruti
Medical Oncology Unit, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, ASST Spedali Civili, Brescia, Italy
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– approval) against a broad spectrum of cancer types including metastatic melanoma, non-small-cell lung cancer, renal cell carcinoma and urothelial cancer ( 6 , 7 , 8 , 9 ). There is a rational in the use of immunotherapy also in ACC. This tumor, in fact
T Szarvas
T Szarvas
Department of Urology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
Department of Urology, Semmelweis University, Budapest, Hungary
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Department of Urology, Semmelweis University, Budapest, Hungary
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B Jardin-Watelet
B Jardin-Watelet
Thermo Fisher Scientific Cezanne SAS, Clinical Diagnostics Division, Nimes, France
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N Bourgoin
N Bourgoin
Thermo Fisher Scientific Cezanne SAS, Clinical Diagnostics Division, Nimes, France
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M J Hoffmann
M J Hoffmann
Department of Urology, Medical Faculty, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany
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P Nyirády
P Nyirády
Department of Urology, Semmelweis University, Budapest, Hungary
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C Oláh
C Oláh
Department of Urology, Semmelweis University, Budapest, Hungary
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T Széll
T Széll
Department of Urology, Semmelweis University, Budapest, Hungary
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A Csizmarik
A Csizmarik
Department of Urology, Semmelweis University, Budapest, Hungary
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B Hadaschik
B Hadaschik
Department of Urology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
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H Reis
H Reis
Institute of Pathology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
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significance. sCGA levels in renal cell carcinoma We found no difference in sCGA levels between RCC patients and age- and gender-matched controls. Serum CGA levels were higher in female patients. No such correlation was observed in the control
Ailsa Maria Main
Ailsa Maria Main
Department of Medical Endocrinology and Metabolism, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
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Maria Rossing
Maria Rossing
Center for Genomic Medicine, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
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Line Borgwardt
Line Borgwardt
Center for Genomic Medicine, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
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Birgitte Grønkær Toft
Birgitte Grønkær Toft
Department of Pathology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
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Åse Krogh Rasmussen
Åse Krogh Rasmussen
Department of Medical Endocrinology and Metabolism, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
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Ulla Feldt-Rasmussen
Ulla Feldt-Rasmussen
Department of Medical Endocrinology and Metabolism, Copenhagen University Hospital, Rigshospitalet, and Faculty of Health, Institute of Clinical and Scientific Research, Copenhagen, Denmark
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a renal cell carcinoma (RCC), therefore the total n is larger than total number of patients with PPGLs. PCC, phaeochromocytoma; PGL, paraganglioma; PPGL, phaeochromocytoma and paraganglioma; SDHX, succinate dehydrogenase genetic variants
Aida Javanbakht
Aida Javanbakht
Department of Diabetes, Endocrinology and Metabolism, Beckman Research Institute of City of Hope, Duarte, California, USA
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Massimo D’Apuzzo
Massimo D’Apuzzo
Department of Pathology, Beckman Research Institute of City of Hope, Duarte, California, USA
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Behnam Badie
Behnam Badie
Department of Neurosurgery, Beckman Research Institute of City of Hope, Duarte, California, USA
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Behrouz Salehian
Behrouz Salehian
Department of Diabetes, Endocrinology and Metabolism, Beckman Research Institute of City of Hope, Duarte, California, USA
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Pit Mets, while the first symptoms in patients with papillary thyroid cancer may be visual ( 123 ). The frequency of renal cell carcinoma is low worldwide ( 148 , 149 ), but it is the fourth most common primary site of Pit Met. This raises the
Wafaa M Rashed
Wafaa M Rashed
Research Department, Children’s Cancer Hospital Egypt (CCHE-57357), Cairo, Egypt
Armed Forces College of Medicine, Cairo, Egypt
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Armed Forces College of Medicine, Cairo, Egypt
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Anas Saad
Anas Saad
Faculty of Medicine, Damascus University, Damascus, Syria
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Muneer Al-Husseini
Muneer Al-Husseini
Faculty of Medicine, Ain Shams University, Cairo, Egypt
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Ahmed Mahmoud Galal
Ahmed Mahmoud Galal
Armed Forces College of Medicine, Cairo, Egypt
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Assem Mohamed Ismael
Assem Mohamed Ismael
Armed Forces College of Medicine, Cairo, Egypt
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Ahmed M Al-Tayep
Ahmed M Al-Tayep
Armed Forces College of Medicine, Cairo, Egypt
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Ayman El Shafie
Ayman El Shafie
Armed Forces College of Medicine, Cairo, Egypt
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Mahmoud Ahmed Ali
Mahmoud Ahmed Ali
Armed Forces College of Medicine, Cairo, Egypt
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Ahmad Samir Alfaar
Ahmad Samir Alfaar
Charité – Universitätsmedizin Berlin, Campus Virchow Klinikum, Ophthalmology Department, Berlin, Germany
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adrenal gland tumors as second primary cancers (clear cell adenocarcinoma, NOS (8310/3) and renal cell carcinoma (8312/3)). Both female breast (27 cases, 23.1%) and prostate (22 cases, 18.8%) were the most frequent primary cancer sites that preceded an
Linfei Yang
Linfei Yang
Center for Medical Experiments, The Third Xiangya Hospital, Central South University, Changsha, China
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Xiao Yu
Xiao Yu
Department of General Surgery, The Third Xiangya Hospital, Central South University, Changsha, China
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Yongchao Yang
Yongchao Yang
Department of Burns and Plastic Surgery, The Third Xiangya Hospital, Central South University, Changsha, China
European Pancreas Center, Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany
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European Pancreas Center, Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany
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, renal cell carcinoma, gastric cancer and colorectal cancer, by enhancing the expression of angiogenesis-related genes such as VEGF ( 20 , 21 , 22 , 23 ). ATX has been reported to be a target of STAT3 transcriptional regulation in breast cancer ( 24
João Castro-Teles
João Castro-Teles
Department of Biomedicine, Faculty of Medicine of the University of Porto, Porto, Portugal
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Bernardo Sousa-Pinto
Bernardo Sousa-Pinto
MEDCIDS, Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal
CINTESIS, Center for Health Technology and Services Research, University of Porto, Porto, Portugal
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CINTESIS, Center for Health Technology and Services Research, University of Porto, Porto, Portugal
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Sandra Rebelo
Sandra Rebelo
Department of Biomedicine, Faculty of Medicine of the University of Porto, Porto, Portugal
Instituto de Investigação e Inovação em Saúde (i3S), Universidade do Porto, Porto, Portugal
Department of Clinical Pathology, Centro Hospitalar Universitário de São João (CHUSJ), Porto, Portugal
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Instituto de Investigação e Inovação em Saúde (i3S), Universidade do Porto, Porto, Portugal
Department of Clinical Pathology, Centro Hospitalar Universitário de São João (CHUSJ), Porto, Portugal
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Duarte Pignatelli
Duarte Pignatelli
Department of Biomedicine, Faculty of Medicine of the University of Porto, Porto, Portugal
Instituto de Investigação e Inovação em Saúde (i3S), Universidade do Porto, Porto, Portugal
Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal
Department of Endocrinology, Centro Hospitalar Universitário de São João (CHUSJ), Porto, Portugal
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Instituto de Investigação e Inovação em Saúde (i3S), Universidade do Porto, Porto, Portugal
Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal
Department of Endocrinology, Centro Hospitalar Universitário de São João (CHUSJ), Porto, Portugal
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classification in type 1, which is typically associated with protein-truncating mutations, or vHL type 2, which mainly associates with missense mutations ( 6 ). vHL type 2 is further subdivided into types 2A (low risk of renal cell carcinoma), 2B (high risk of
Anna Olsson-Brown
Anna Olsson-Brown
Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK
The Clatterbridge Cancer Centre, Wirral, UK
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The Clatterbridge Cancer Centre, Wirral, UK
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Rosemary Lord
Rosemary Lord
The Clatterbridge Cancer Centre, Wirral, UK
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Joseph Sacco
Joseph Sacco
The Clatterbridge Cancer Centre, Wirral, UK
Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool, UK
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Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool, UK
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Jonathan Wagg
Jonathan Wagg
Roche Innovation Center, Basel, Switzerland
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Mark Coles
Mark Coles
Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK
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Munir Pirmohamed
Munir Pirmohamed
Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK
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nivolumab and ipilimumab ( 1 , 2 , 6 ). ICIs are now used in the mainstream treatment of metastatic melanoma, non-small cell lung cancer renal cell carcinoma, urothelial and head and neck cancers ( 7 , 8 ). Nivolumab and pembrolizumab also hold global
Jaafar Jaafar
Jaafar Jaafar
Division of Endocrinology and Diabetology, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland
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Eugenio Fernandez
Eugenio Fernandez
Department of Oncology, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland
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Heba Alwan
Heba Alwan
Division of Endocrinology and Diabetology, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland
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Jacques Philippe
Jacques Philippe
Division of Endocrinology and Diabetology, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland
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such as advanced metastatic melanoma, colorectal cancer (CRC), renal cell carcinoma (RCC), NSCLC and castration-resistant prostate cancer ( 13 ). The role of this human IgG4 monoclonal antibody mAb has been largely proved as an immune checkpoint
