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Satoshi Higuchi, Hideki Ota, Takuya Ueda, Yuta Tezuka, Kei Omata, Yoshikiyo Ono, Ryo Morimoto, Masataka Kudo, Fumitoshi Satoh and Kei Takase

), and mammalian hearts have a higher concentration of β-adrenoceptors in the apical myocardium, with the concentration decreasing in a gradient from the apex to the base ( 19 , 34 ). These findings could explain the regional differences in response to

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Julia H Goedecke, Mehreen Tootla and Dheshnie Keswell

) mice present with high levels of VAT, insulin resistance and impaired glucose tolerance ( 11 , 12 , 13 ). Human studies have demonstrated regional differences in adipose tissue ERA , ERB and CYP19A1 expression, which may be altered by sex and age

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Ning Yao, Chunbei Zhou, Jun Xie, Xinshu Li, Qianru Zhou, Jing Chen and Shuang Zhou

eliminated IDD and three provinces were ‘almost eliminated’ ( 5 ). But regional difference of iodine nutritional status of school aged children and pregnant women among provinces still existed. According to China’s 2011 National IDD Surveillance results ( 5

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Sara Ullsten, Sara Bohman, Marie E Oskarsson, K Peter R Nilsson, Gunilla T Westermark and Per-Ola Carlsson

regions of the pancreas ( 40 ). We did, in our studies in mice, however, not find any regional differences of the position of microsphere-containing islets. Processing deficiencies of proIAPP has been suggested to contribute to islet amyloid development

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Giorgio Radetti, Mariacarolina Salerno, Chiara Guzzetti, Marco Cappa, Andrea Corrias, Alessandra Cassio, Graziano Cesaretti, Roberto Gastaldi, Mario Rotondi, Fiorenzo Lupi, Antonio Fanolla, Giovanna Weber and Sandro Loche

to a more severe course of HT with development of hypothyroidism ( 31 , 32 , 33 ). CXCL10 concentrations, however, were not different between groups. Furthermore, regional differences in iodine concentration should not have influenced our results

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Roberto Cosimo Melcangi, Livio Casarini, Marco Marino, Daniele Santi, Samantha Sperduti, Silvia Giatti, Silvia Diviccaro, Maria Grimoldi, Donatella Caruso, Guido Cavaletti and Manuela Simoni

://doi.org/10.1038/nature12433 ) 23925113 40 Devall M Smith RG Jeffries A Hannon E Davies MN Schalkwyk L Mill J Weedon M Lunnon K . Regional differences in mitochondrial DNA methylation in human post-mortem brain tissue . Clinical

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Suma Uday, Ardita Kongjonaj, Magda Aguiar, Ted Tulchinsky and Wolfgang Högler

inconsistent responses where noted when there was more than one respondent, which may reflect regional differences within countries. However, in the absence of national data, estimation by experts in the field was the next best alternative. Data from 22

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Xiaomin Nie, Yiting Xu, Xiaojing Ma, Yun Shen, Yufei Wang and Yuqian Bao

Karagiannides I Pothoulakis C Jensen MD Kirkland JL . Mechanisms and metabolic implications of regional differences among fat depots . Cell Metabolism 2013 644 – 656 . ( https://doi.org/10.1016/j.cmet.2013.03.008 ) 23583168 22 Koutsari C Ali

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Antonia Ertelt, Ann-Kristin Barton, Robert R Schmitz and Heidrun Gehlen

2009 33 978 – 990 . ( doi:10.1038/ijo.2009.133 ). 26 Ostman J Arner P Engfeldt P Kager L . Regional differences in the control of lipolysis in human adipose tissue . Metabolism 1979 28 1198 – 1205 . ( doi:10

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Patricia Iozzo and Maria Angela Guzzardi

metabolism in humans . Diabetes 1999 1915 – 1921 . ( https://doi.org/10.2337/diabetes.48.10.1915 ) 51 Cranston I Marsden P Matyka K Evans M Lomas J Sonksen P Maisey M Amiel SA . Regional differences in cerebral blood flow and glucose