Marek Niedziela
Marek Niedziela
Department of Pediatric Endocrinology and Rheumatology, Institute of Pediatrics, Karol Jonscher’s Clinical Hospital, Poznan University of Medical Sciences, Poznan, Poland
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replacement. Two definitive options – (a) surgery and (b) radioiodine (I-131 (RAI)) – followed by life-long treatment with LT4. The treatment of other, less frequent forms of hyperthyroidism in children depends on their cause and whether coexisting
C Chiapponi
C Chiapponi
Department of General, Visceral, Cancer and Transplant Surgery, University Hospital of Cologne, Cologne, Germany
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H Alakus
H Alakus
Department of General, Visceral, Cancer and Transplant Surgery, University Hospital of Cologne, Cologne, Germany
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M Faust
M Faust
Polyclinic for Endocrinology, Diabetes and Preventive Medicine, University Hospital of Cologne, Cologne, Germany
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A M Schultheis
A M Schultheis
Department of Pathology, University Hospital of Cologne, Cologne, Germany
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J Rosenbrock
J Rosenbrock
Department of Radiation Therapy, University Hospital of Cologne, Cologne, Germany
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M Schmidt
M Schmidt
Department of Nuclear Medicine, Faculty of Medicine, University Hospital of Cologne, Cologne, Germany
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, 4 ); it bears the risk of postoperative hypocalcemia, and radioiodine treatment (RAI) is known to treat micrometastatic disease ( 5 ). The excellent response of DTC to RAI, besides its indolent behavior, is the main reason for its excellent
Muthiah Subramanian
Muthiah Subramanian
Department of General Medicine, TB and Pulmonary Medicine, Endocrinology, Sri Ramachandra University, 1 Ramachandra Nagar, Porur, Chennai 600116, India
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Manu Kurian Baby
Manu Kurian Baby
Department of General Medicine, TB and Pulmonary Medicine, Endocrinology, Sri Ramachandra University, 1 Ramachandra Nagar, Porur, Chennai 600116, India
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Krishna G Seshadri
Krishna G Seshadri
Department of General Medicine, TB and Pulmonary Medicine, Endocrinology, Sri Ramachandra University, 1 Ramachandra Nagar, Porur, Chennai 600116, India
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Introduction Although antithyroid drugs (ATDs) and partial thyroidectomy have established the treatment modalities, radioiodine therapy has become the primary treatment option of hyperthyroidism in Graves' disease (1, 2) . A number of interrelated
Teresa Kraus
Teresa Kraus
Division of Nuclear Medicine, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria
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Natalia Shengelia-de Lange
Natalia Shengelia-de Lange
Division of Nuclear Medicine, Tbilisi State Medical University, Tbilisi, Georgia
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Holger Einspieler
Holger Einspieler
Division of Nuclear Medicine, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria
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Marcus Hacker
Marcus Hacker
Division of Nuclear Medicine, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria
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Alexander Haug
Alexander Haug
Division of Nuclear Medicine, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria
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Elisabeth Kretschmer-Chott
Elisabeth Kretschmer-Chott
Division of Nuclear Medicine, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria
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Georgios Karanikas
Georgios Karanikas
Division of Nuclear Medicine, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria
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DTC, which may include a total thyroidectomy and radioiodine remnant ablation, a follow-up visit is scheduled 4–12 months later. To determine the clinical outcome of the individual patient, several tests and examinations are performed. Thyroglobulin
Lian Duan
Lian Duan
Department of Nuclear Medicine, Heping Hospital Affiliated to Changzhi Medical College, Changzhi, Shanxi, China
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Han-Yu Zhang
Han-Yu Zhang
Changzhi Medical College, Changzhi, Shanxi, China
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Min Lv
Min Lv
Department of Nuclear Medicine, Heping Hospital Affiliated to Changzhi Medical College, Changzhi, Shanxi, China
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Han Zhang
Han Zhang
Changzhi Medical College, Changzhi, Shanxi, China
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Yao Chen
Yao Chen
Changzhi Medical College, Changzhi, Shanxi, China
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Ting Wang
Ting Wang
Department of Nuclear Medicine, Heping Hospital Affiliated to Changzhi Medical College, Changzhi, Shanxi, China
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Yan Li
Yan Li
Department of Nuclear Medicine, Heping Hospital Affiliated to Changzhi Medical College, Changzhi, Shanxi, China
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Yan Wu
Yan Wu
Department of Clinical Laboratory, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong, China
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Junfeng Li
Junfeng Li
Department of Radiology, Heping Hospital Affiliated to Changzhi Medical College, Changzhi, Shanxi, China
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Kefeng Li
Kefeng Li
School of Medicine, University of California, San Diego, California, USA
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per 100,000 individuals per year ( 3 , 4 ). Current treatment for GD patients includes antithyroid drugs (ATDs), radioiodine therapy ( 131 I therapy) (RAI), and thyroidectomy ( 5 ). ATDs tend to have a higher failure rate. In addition, approximately
Guoquan Zhu
Guoquan Zhu
Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, China
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Yuying Deng
Yuying Deng
Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, China
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Liqin Pan
Liqin Pan
Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, China
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Wei Ouyang
Wei Ouyang
Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, China
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Huijuan Feng
Huijuan Feng
Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, China
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Juqing Wu
Juqing Wu
Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, China
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Pan Chen
Pan Chen
Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, China
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Jing Wang
Jing Wang
Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, China
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Yanying Chen
Yanying Chen
Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, China
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Jiaxin Luo
Jiaxin Luo
Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, China
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significantly reduces sodium-iodide symporter (NIS) expression and radioiodine uptake ability and influences RAI therapy to the point of causing RAI-refractory PTC. Jiao et al . ( 16 ) designed their research concerning RAI therapy and PTC with the BRAF V600E
Eugenie S Lim
Eugenie S Lim
Barts Health NHS Trust, Barts and the London School of Medicine and Dentistry, London, UK
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Shanty G Shah
Shanty G Shah
Barts and the London School of Medicine and Dentistry, QMUL, London, UK
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Mona Waterhouse
Mona Waterhouse
Barts Health NHS Trust, Barts and the London School of Medicine and Dentistry, London, UK
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Scott Akker
Scott Akker
Barts Health NHS Trust, Barts and the London School of Medicine and Dentistry, London, UK
Barts and the London School of Medicine and Dentistry, QMUL, London, UK
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Barts and the London School of Medicine and Dentistry, QMUL, London, UK
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William Drake
William Drake
Barts Health NHS Trust, Barts and the London School of Medicine and Dentistry, London, UK
Barts and the London School of Medicine and Dentistry, QMUL, London, UK
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Barts and the London School of Medicine and Dentistry, QMUL, London, UK
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Nick Plowman
Nick Plowman
Barts Health NHS Trust, Barts and the London School of Medicine and Dentistry, London, UK
Barts and the London School of Medicine and Dentistry, QMUL, London, UK
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Barts and the London School of Medicine and Dentistry, QMUL, London, UK
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Daniel M Berney
Daniel M Berney
Barts Health NHS Trust, Barts and the London School of Medicine and Dentistry, London, UK
Barts and the London School of Medicine and Dentistry, QMUL, London, UK
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Barts and the London School of Medicine and Dentistry, QMUL, London, UK
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Polly Richards
Polly Richards
Barts Health NHS Trust, Barts and the London School of Medicine and Dentistry, London, UK
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Ashok Adams
Ashok Adams
Barts Health NHS Trust, Barts and the London School of Medicine and Dentistry, London, UK
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Ewa Nowosinska
Ewa Nowosinska
Barts Health NHS Trust, Barts and the London School of Medicine and Dentistry, London, UK
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Carmel Brennan
Carmel Brennan
Barts Health NHS Trust, Barts and the London School of Medicine and Dentistry, London, UK
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Maralyn Druce
Maralyn Druce
Barts Health NHS Trust, Barts and the London School of Medicine and Dentistry, London, UK
Barts and the London School of Medicine and Dentistry, QMUL, London, UK
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Barts and the London School of Medicine and Dentistry, QMUL, London, UK
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complications (dry mouth, loss of taste sensation, reduced spermatogenesis and risk of secondary malignancies), while maximising the likelihood of successful remnant ablation. Further to this, the IoN trial is in progress to assess whether omitting radioiodine
Jiaxin Luo
Jiaxin Luo
Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China
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Weili Yin
Weili Yin
Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China
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Qiuxia Lin
Qiuxia Lin
The Second School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong Province, China
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Juqing Wu
Juqing Wu
Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China
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Pan Chen
Pan Chen
Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China
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Yuanna Ling
Yuanna Ling
Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China
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Jing Wang
Jing Wang
Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China
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Zhen Li
Zhen Li
Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China
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Liqin Pan
Liqin Pan
Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China
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Yanying Chen
Yanying Chen
Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China
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Wei Ouyang
Wei Ouyang
Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China
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Huijuan Feng
Huijuan Feng
Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China
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surgery, radioiodine therapy (RAIT), external beam radiation therapy (EBRT), and bisphosphonate therapy ( 11 ). The American Thyroid Association noted that although radioiodine (I-131) is less likely to cure bone metastases, patients with positive I-131
M L Gild
M L Gild
Cancer Genetics Laboratory, Department of Endocrinology, Kolling Institute of Medical Research, Sydney, New South Wales, Australia
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M Bullock
M Bullock
Cancer Genetics Laboratory, Department of Endocrinology, Kolling Institute of Medical Research, Sydney, New South Wales, Australia
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C K Pon
C K Pon
Cancer Genetics Laboratory, Department of Endocrinology, Kolling Institute of Medical Research, Sydney, New South Wales, Australia
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B G Robinson
B G Robinson
Cancer Genetics Laboratory, Department of Endocrinology, Kolling Institute of Medical Research, Sydney, New South Wales, Australia
Cancer Genetics Laboratory, Department of Endocrinology, Kolling Institute of Medical Research, Sydney, New South Wales, Australia
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Cancer Genetics Laboratory, Department of Endocrinology, Kolling Institute of Medical Research, Sydney, New South Wales, Australia
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R J Clifton-Bligh
R J Clifton-Bligh
Cancer Genetics Laboratory, Department of Endocrinology, Kolling Institute of Medical Research, Sydney, New South Wales, Australia
Cancer Genetics Laboratory, Department of Endocrinology, Kolling Institute of Medical Research, Sydney, New South Wales, Australia
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Cancer Genetics Laboratory, Department of Endocrinology, Kolling Institute of Medical Research, Sydney, New South Wales, Australia
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-AAG reduced papillary thyroid cancer 1 (PTC1) expression levels and increased radioiodine accumulation in PCCL3 thyroid cells where PTC1 was induced by doxycycline (14) . This was determined to be independent of the sodium iodide symporter (NIS) and
Kim Magaly Pabst
Kim Magaly Pabst
Department of Nuclear Medicine, West German Cancer Center, University Hospital Essen, Essen, Germany
German Cancer Consortium (DKTK), Partner site University Hospital Essen, Essen, Germany
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German Cancer Consortium (DKTK), Partner site University Hospital Essen, Essen, Germany
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Robert Seifert
Robert Seifert
Department of Nuclear Medicine, West German Cancer Center, University Hospital Essen, Essen, Germany
German Cancer Consortium (DKTK), Partner site University Hospital Essen, Essen, Germany
Department of Nuclear Medicine, University Hospital Münster, Münster, Germany
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German Cancer Consortium (DKTK), Partner site University Hospital Essen, Essen, Germany
Department of Nuclear Medicine, University Hospital Münster, Münster, Germany
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Nader Hirmas
Nader Hirmas
Department of Nuclear Medicine, West German Cancer Center, University Hospital Essen, Essen, Germany
German Cancer Consortium (DKTK), Partner site University Hospital Essen, Essen, Germany
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German Cancer Consortium (DKTK), Partner site University Hospital Essen, Essen, Germany
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Martina Broecker-Preuss
Martina Broecker-Preuss
Department of Medicine, Ruhr-University Bochum, University Hospital, Knappschaftskrankenhaus Bochum, Bochum, Germany
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Manuel Weber
Manuel Weber
Department of Nuclear Medicine, West German Cancer Center, University Hospital Essen, Essen, Germany
German Cancer Consortium (DKTK), Partner site University Hospital Essen, Essen, Germany
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German Cancer Consortium (DKTK), Partner site University Hospital Essen, Essen, Germany
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Wolfgang Peter Fendler
Wolfgang Peter Fendler
Department of Nuclear Medicine, West German Cancer Center, University Hospital Essen, Essen, Germany
German Cancer Consortium (DKTK), Partner site University Hospital Essen, Essen, Germany
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German Cancer Consortium (DKTK), Partner site University Hospital Essen, Essen, Germany
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Timo Bartel
Timo Bartel
Department of Nuclear Medicine, West German Cancer Center, University Hospital Essen, Essen, Germany
German Cancer Consortium (DKTK), Partner site University Hospital Essen, Essen, Germany
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German Cancer Consortium (DKTK), Partner site University Hospital Essen, Essen, Germany
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Sarah Theurer
Sarah Theurer
German Cancer Consortium (DKTK), Partner site University Hospital Essen, Essen, Germany
Institute of Pathology, University Hospital Essen, University Duisburg-Essen, Essen, Germany
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Institute of Pathology, University Hospital Essen, University Duisburg-Essen, Essen, Germany
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Ken Herrmann
Ken Herrmann
Department of Nuclear Medicine, West German Cancer Center, University Hospital Essen, Essen, Germany
German Cancer Consortium (DKTK), Partner site University Hospital Essen, Essen, Germany
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German Cancer Consortium (DKTK), Partner site University Hospital Essen, Essen, Germany
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Rainer Görges
Rainer Görges
Department of Nuclear Medicine, West German Cancer Center, University Hospital Essen, Essen, Germany
German Cancer Consortium (DKTK), Partner site University Hospital Essen, Essen, Germany
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German Cancer Consortium (DKTK), Partner site University Hospital Essen, Essen, Germany
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Key points At a follow-up of >10 years, a single stimulated Tg measurement (maximum 24 months after last radioiodine therapy) seems to have a high predictive power for RFS. At a follow-up >10 years, a single highly sensitive measured
