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Farzaneh Rohani, Mohammad Reza Alai, Sedighe Moradi and Davoud Amirkashani

Introduction Constitutional delay in growth and puberty (CDGP) is the most common cause of short stature and puberty delay in boys ( 1 , 2 , 3 , 4 ). This condition is considered as a normal variation, and affected individuals typically

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Emmanuelle Motte, Anya Rothenbuhler, Stephan Gaillard, Najiba Lahlou, Cécile Teinturier, Régis Coutant and Agnès Linglart

year after surgery than after 1 year on mitotane (1.6 (±0.4) vs −0.2 (±0.6), respectively; P  = 0.006). Among the 17 patients who had reached the average age of onset of puberty (girls over 11 and boys over 12 years of age) at diagnosis, 15 presented

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Annette Mouritsen, Alexander Siegfried Busch, Lise Aksglaede, Ewa Rajpert-De Meyts and Anders Juul

Introduction Testosterone (T) promotes maturation of the male reproductive organs, development of secondary sex characteristics and production of sperm by the testes. In puberty in boys, pulsatile gonadotropin stimulation upon reactivation of

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Bruno Donadille, Muriel Houang, Irène Netchine, Jean-Pierre Siffroi and Sophie Christin-Maitre

HSD3B2 mutations ( 1 , 2 , 5 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 29 ). Most of them entered puberty spontaneously. The explanation relies on a potential accumulation above the enzymatic deficit of delta 5-steroids

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Shenglong Le, Leiting Xu, Moritz Schumann, Na Wu, Timo Törmäkangas, Markku Alén, Sulin Cheng and Petri Wiklund

puberty, and thereafter start to rise again until early adulthood ( 2 , 3 , 4 ). The mechanism for the decline in SHBG during puberty is not clear, but is likely driven by other factors in addition to sex steroids since SHBG levels also decline in boys

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Elena Galazzi, Paolo Duminuco, Mirella Moro, Fabiana Guizzardi, Nicoletta Marazzi, Alessandro Sartorio, Sabrina Avignone, Marco Bonomi, Luca Persani and Maria Teresa Bonati

association between TBX3 variants with isolated hypogonadotropic hypogonadism (IHH), signs of hypogonadism, including bilateral cryptorchidism, micropenis and delayed puberty, have been repeatedly reported among patients with UMS ( 3 , 4 , 5 , 6 , 7 , 8

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Iben Katinka Greiber, Casper P Hagen, Alexander Siegfried Busch, Mikkel Grunnet Mieritz, Lise Aksglæde, Katharina Main, Kristian Almstrup and Anders Juul

persistent Müllerian duct syndrome (PMDS) often including bilateral cryptorchidism but otherwise normal virilization of external genitalia ( 7 ). In postnatal life, serum levels of AMH are high during childhood but decline rapidly during puberty when the

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Nicolás Crisosto, Bárbara Echiburú, Manuel Maliqueo, Marta Luchsinger, Pedro Rojas, Sergio Recabarren and Teresa Sir-Petermann

groups ( 14 ). Regarding metabolic features, we observed increased weight from an early age and some indicators of insulin resistance during adulthood ( 12 ). Puberty is a transition period between childhood and adulthood accompanied by profound changes

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Xi Wang and Qi Yu

/1,000,000 ( 1 , 2 ). MAS is defined historically as the triad of peripheral precocious puberty (PP), café-au-lait skin pigmentation and fibrous dysplasia (FD) of the bone ( 3 ). Other associated hyperfunctioning endocrinopathies include hyperthyroidism, growth

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Agnieszka Pazderska, Yaasir Mamoojee, Satish Artham, Margaret Miller, Stephen G Ball, Tim Cheetham and Richard Quinton

Introduction Delayed puberty is defined by the absence of testicular development 2.5 s.d. later than the population mean – typically 14 years of age in males ( 1 ). Although the majority of cases at age 14 have constitutional delay (CDP