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Renea A Taylor Department of Physiology, Cancer Program and Obesity and Metabolic Disease Program, Biomedicine Discovery Institute, Monash University, Wellington Road, Victoria 3800, Australia

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Jennifer Lo Department of Physiology, Cancer Program and Obesity and Metabolic Disease Program, Biomedicine Discovery Institute, Monash University, Wellington Road, Victoria 3800, Australia

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Natasha Ascui Department of Physiology, Cancer Program and Obesity and Metabolic Disease Program, Biomedicine Discovery Institute, Monash University, Wellington Road, Victoria 3800, Australia

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Matthew J Watt Department of Physiology, Cancer Program and Obesity and Metabolic Disease Program, Biomedicine Discovery Institute, Monash University, Wellington Road, Victoria 3800, Australia

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Epidemiology of prostate cancer and obesity Prostate cancer Prostate cancer is an androgen-dependent malignancy that affects the aging male population, with the mean age at diagnosis being 66 years (1) . Over the past decade, the incidence of

Article Type:
Review Article
DOI:
https://doi.org/10.1530/EC-15-0080
Volume/Issue:
Volume 4: Issue 4
Open access
Zhen-yu Song Department of Urology, Jinshan Hospital of Fudan University, Shanghai, China

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Qiuming Yao Department of Endocrinology, Jinshan Hospital of Fudan University, Shanghai, China

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Zhiyuan Zhuo Department of Urology, Jinshan Hospital of Fudan University, Shanghai, China

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Zhe Ma Department of Urology, Jinshan Hospital of Fudan University, Shanghai, China

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Gang Chen Department of Urology, Jinshan Hospital of Fudan University, Shanghai, China

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Introduction Prostate cancer (PCa) is one of the most common malignant tumors in male. In 2017, American Cancer Society reported 161,360 cases of newly diagnosed PCa, accounting for 20% of male tumors. Furthermore, its incidence and mortality

Article Type:
Review Article
DOI:
https://doi.org/10.1530/EC-18-0283
Volume/Issue:
Volume 7: Issue 12
Open access
Emma Jernberg Department of Medical biosciences, Umeå University, Umeå, Sweden

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Anders Bergh Department of Medical biosciences, Umeå University, Umeå, Sweden

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Pernilla Wikström Department of Medical biosciences, Umeå University, Umeå, Sweden

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Introduction Prostate cancer (PC) is one of the most common forms of cancer and a leading cause of cancer-related deaths in men worldwide ( 1 ). Androgens regulate normal and malignant prostate tissue growth via activation of androgen receptor

Article Type:
Review Article
DOI:
https://doi.org/10.1530/EC-17-0118
Volume/Issue:
Volume 6: Issue 8
Open access
Mélanie Rouleau Division of Urology, Department of Surgery and Cancer Research Center, Centre Hospitalier Universitaire (CHU) de Québec-Université Laval, Québec, Québec, Canada

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Francis Lemire Division of Urology, Department of Surgery and Cancer Research Center, Centre Hospitalier Universitaire (CHU) de Québec-Université Laval, Québec, Québec, Canada

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Michel Déry Biochemistry Service, Medical Laboratory Department, CHU de Québec-Université Laval, Québec, Québec, Canada

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Benoît Thériault Division of Urology, Department of Surgery and Cancer Research Center, Centre Hospitalier Universitaire (CHU) de Québec-Université Laval, Québec, Québec, Canada

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Gabriel Dubois Division of Urology, Department of Surgery and Cancer Research Center, Centre Hospitalier Universitaire (CHU) de Québec-Université Laval, Québec, Québec, Canada

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Yves Fradet Division of Urology, Department of Surgery and Cancer Research Center, Centre Hospitalier Universitaire (CHU) de Québec-Université Laval, Québec, Québec, Canada

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Paul Toren Division of Urology, Department of Surgery and Cancer Research Center, Centre Hospitalier Universitaire (CHU) de Québec-Université Laval, Québec, Québec, Canada

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Chantal Guillemette Pharmacy Faculty, Université Laval and CHU de Québec-Université Laval, Québec, Québec, Canada

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Louis Lacombe Division of Urology, Department of Surgery and Cancer Research Center, Centre Hospitalier Universitaire (CHU) de Québec-Université Laval, Québec, Québec, Canada

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Laurence Klotz Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada

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Fred Saad Centre Hospitalier de l’Université de Montréal, Montréal, Québec, Canada

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Dominique Guérette Biochemistry Service, Medical Laboratory Department, CHU de Québec-Université Laval, Québec, Québec, Canada

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Frédéric Pouliot Division of Urology, Department of Surgery and Cancer Research Center, Centre Hospitalier Universitaire (CHU) de Québec-Université Laval, Québec, Québec, Canada

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). Recent studies have suggested that testosterone levels <0.7 nM under ADT are associated rather with a longer time to castration-resistant prostate cancer (CRPC) or death compared to higher testosterone levels ( 4 , 12 , 13 , 14 , 15 , 16 , 17

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-18-0476
Volume/Issue:
Volume 8: Issue 2
Open access
Orwa Dandash Department of Psychiatry, University of Melbourne, Austin Health, Heidelberg, Victoria, Australia

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James Allebone Department of Psychiatry, University of Melbourne, Austin Health, Heidelberg, Victoria, Australia

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Adam Mirabelli Department of Psychiatry, University of Melbourne, Austin Health, Heidelberg, Victoria, Australia

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Nicholas Russell Department of Endocrinology, Austin Health, Heidelberg, Victoria, Australia

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Mathis Grossmann Department of Endocrinology, Austin Health, Heidelberg, Victoria, Australia

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Andrea Gogos Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia
Department of Florey Institute, University of Melbourne, Parkville, Victoria, Australia

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Richard A Kanaan Department of Psychiatry, University of Melbourne, Austin Health, Heidelberg, Victoria, Australia

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Introduction Androgen deprivation therapy (ADT) using gonadotropin-releasing hormone (GnRH) agonists is one of the mainstay therapies for prostate cancer ( 1 ). This therapy reduces circulating testosterone to castrate concentrations

Article Type:
Research Article
Collections:
Hormones and Cancer
DOI:
https://doi.org/10.1530/EC-23-0409
Volume/Issue:
Volume 13: Issue 3
Open access
Doron Weinstein
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Rive Sarfstein
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Zvi Laron Department of Human Molecular Genetics and Biochemistry, Endocrinology and Diabetes Research Unit, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel

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Haim Werner
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Introduction Prostate cancer (PCa) is the second most frequently diagnosed cancer in men and the third most common cause of death in men aged over 50 years in developed countries. Apart from age, race, and a positive family history are among the

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-13-0086
Volume/Issue:
Volume 3: Issue 1
Open access
Vita Birzniece School of Medicine, Western Sydney University, New South Wales, Australia
Department of Diabetes and Endocrinology, Blacktown Hospital, New South Wales, Australia
Garvan Institute of Medical Research, New South Wales, Australia
School of Medical Sciences, University of New South Wales, New South Wales, Australia

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Teresa Lam School of Medicine, Western Sydney University, New South Wales, Australia
Department of Diabetes and Endocrinology, Blacktown Hospital, New South Wales, Australia
Department of Diabetes and Endocrinology, Westmead Hospital, New South Wales, Australia

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Mark McLean School of Medicine, Western Sydney University, New South Wales, Australia
Department of Diabetes and Endocrinology, Blacktown Hospital, New South Wales, Australia

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Navneeta Reddy Department of Diabetes and Endocrinology, Blacktown Hospital, New South Wales, Australia

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Haleh Shahidipour School of Medicine, Western Sydney University, New South Wales, Australia
Department of Diabetes and Endocrinology, Blacktown Hospital, New South Wales, Australia

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Amy Hayden School of Medicine, Western Sydney University, New South Wales, Australia
Faculty of Medicine, Health and Human Sciences, Macquarie University, New South Wales, Australia
Crown Princess Mary Cancer Centre, Westmead Hospital, New South Wales, Australia

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Howard Gurney Crown Princess Mary Cancer Centre, Westmead Hospital, New South Wales, Australia

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Glenn Stone School of Computing, Engineering and Mathematics, Western Sydney University, New South Wales, Australia

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Rikke Hjortebjerg Department of Clinical Medicine, Aarhus University, Aarhus, Denmark
Endocrine Research Unit, Department of Endocrinology, Odense University Hospital & Department of Clinical Research, Faculty of Health, University of Southern Denmark, Odense, Denmark
Steno Diabetes Center Odense, Odense University Hospital & Department of Clinical Research, Faculty of Health, University of Southern Denmark, Odense, Denmark

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Jan Frystyk Department of Clinical Medicine, Aarhus University, Aarhus, Denmark
Endocrine Research Unit, Department of Endocrinology, Odense University Hospital & Department of Clinical Research, Faculty of Health, University of Southern Denmark, Odense, Denmark

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Introduction Prostate cancer is the most common solid organ cancer in men and androgen deprivation therapy (ADT) is a principal therapy. While ADT improves cancer symptoms and survival in prostate cancer patients, because of the induced

Article Type:
Research Article
Collections:
Hormones and Cancer
DOI:
https://doi.org/10.1530/EC-21-0375
Volume/Issue:
Volume 11: Issue 4
Open access
Herjan J T Coelingh Bennink Pantarhei Oncology, Zeist, The Netherlands

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Jan Krijgh Pantarhei Oncology, Zeist, The Netherlands

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Jan F M Egberts Terminal 4 Communications, Hilversum, The Netherlands

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Maria Slootweg Independent Consultant, Zeist, The Netherlands

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Harm H E van Melick Department of Urology, St. Antonius Hospital, Nieuwegein, The Netherlands

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Erik P M Roos Department of Urology, Antonius Hospital, Sneek, The Netherlands

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Diederik M Somford Department of Urology, Canisius-Wilhelmina Hospital, Nijmegen, The Netherlands

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Yvette Zimmerman Pantarhei Oncology, Zeist, The Netherlands

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Iman J Schultz Pantarhei Oncology, Zeist, The Netherlands

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Noel W Clarke The Christie and Salford Royal NHS Foundation Trusts, Manchester, UK

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R Jeroen A van Moorselaar Department of Urology, Amsterdam UMC, VU University, Amsterdam, The Netherlands

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Frans M J Debruyne Andros Clinics, Arnhem, The Netherlands

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Introduction Prostate cancer (PCa) is the second most frequently diagnosed cancer in men worldwide. For decades, androgen deprivation therapy (ADT) has been the cornerstone of treatment for various stages of locally advanced or metastatic PCa

Article Type:
Review Article
Collections:
Bone and Mineral Metabolism
DOI:
https://doi.org/10.1530/EC-22-0182
Volume/Issue:
Volume 11: Issue 12
Open access
T S Nilsen Department of Physical Performance, Norwegian School of Sports Sciences, Oslo, Norway

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L Thorsen Department of Oncology, Oslo University Hospital, Oslo, Norway

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C Kirkegaard Department of Physical Performance, Norwegian School of Sports Sciences, Oslo, Norway

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I Ugelstad Department of Physical Performance, Norwegian School of Sports Sciences, Oslo, Norway

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S D Fosså Department of Oncology, Oslo University Hospital, Oslo, Norway

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T Raastad Department of Physical Performance, Norwegian School of Sports Sciences, Oslo, Norway

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Introduction Prostate cancer (PCa) patients with locally advanced disease are often treated with androgen deprivation therapy (ADT) to prevent tumour progression ( 1 ). Loss of skeletal muscle mass is a common side effect of ADT ( 2 , 3 , 4

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-15-0120
Volume/Issue:
Volume 5: Issue 2
Open access
Teresa Lam School of Medicine, Western Sydney University, Penrith, New South Wales, Australia
Department of Diabetes and Endocrinology, Blacktown Hospital, Blacktown, New South Wales, Australia
Department of Diabetes and Endocrinology, Westmead Hospital, Westmead, New South Wales, Australia

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Mark McLean School of Medicine, Western Sydney University, Penrith, New South Wales, Australia
Department of Diabetes and Endocrinology, Blacktown Hospital, Blacktown, New South Wales, Australia

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Amy Hayden Department of Radiation Oncology, Blacktown Hospital, Blacktown, New South Wales, Australia
Crown Princess Mary Cancer Centre, Westmead Hospital, Westmead, New South Wales, Australia

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Anne Poljak Bioanalytical Mass Spectrometry Facility and School of Medical Sciences, UNSW Sydney, Sydney, New South Wales, Australia

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Birinder Cheema School of Science and Health, Western Sydney University, Penrith, New South Wales, Australia

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Howard Gurney Crown Princess Mary Cancer Centre, Westmead Hospital, Westmead, New South Wales, Australia

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Glenn Stone School of Computing, Engineering and Mathematics, Western Sydney University, Penrith, New South Wales, Australia

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Neha Bahl School of Medicine, Western Sydney University, Penrith, New South Wales, Australia

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Navneeta Reddy Department of Diabetes and Endocrinology, Blacktown Hospital, Blacktown, New South Wales, Australia
Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia

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Haleh Shahidipour School of Medicine, Western Sydney University, Penrith, New South Wales, Australia
Department of Diabetes and Endocrinology, Blacktown Hospital, Blacktown, New South Wales, Australia
School of Medicine, UNSW Sydney, Sydney, New South Wales, Australia
Translational Health Research Institute, Penrith, New South Wales, Australia

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Vita Birzniece School of Medicine, Western Sydney University, Penrith, New South Wales, Australia
Department of Diabetes and Endocrinology, Blacktown Hospital, Blacktown, New South Wales, Australia
Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia
School of Medicine, UNSW Sydney, Sydney, New South Wales, Australia
Translational Health Research Institute, Penrith, New South Wales, Australia

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). Androgen deprivation therapy (ADT) used for the treatment of prostate cancer suppresses testosterone to castrate levels. This results in a rapid loss of muscle mass far exceeding that of normal aging ( 6 , 7 ). Thus, ADT offers a unique model to study the

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-19-0179
Volume/Issue:
Volume 8: Issue 5
Open access