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Natalie Rogowski-Lehmann, Aikaterini Geroula, Aleksander Prejbisz, Henri J L M Timmers, Felix Megerle, Mercedes Robledo, Martin Fassnacht, Stephanie M J Fliedner, Martin Reincke, Anthony Stell, Andrzej Januszewicz, Jacques W M Lenders, Graeme Eisenhofer and Felix Beuschlein

patients in clinical practice. Indeed, over the years, the proportion of patients has shifted from symptomatic cases to those that are incidentally detected or undergo routine surveillance. Despite these well-appreciated changes, there were no prospective

Open access

N Bergmann, F Gyntelberg and J Faber

synthesis from prospective cohort studies, in which chronic stress, measured by Qs, has been evaluated as potential risk factors for the development of MES as well as for the individual components of MES. Subjects and methods Search strategy A systematic

Open access

Soraya Puglisi, Paola Perotti, Mattia Barbot, Paolo Cosio, Carla Scaroni, Antonio Stigliano, Pina Lardo, Valentina Morelli, Elisa Polledri, Iacopo Chiodini, Giuseppe Reimondo, Anna Pia and Massimo Terzolo

been studied prospectively. Retrospective studies have shown that metyrapone is effective in promptly reducing cortisol levels. Cortisol dropped within target levels after 48–72 h from initiation of treatment with no later escape ( 8 , 9 ). Adverse

Open access

Philippe Thuillier, Nathalie Roudaut, Geneviève Crouzeix, Marie Cavarec, Philippe Robin, Ronan Abgral, Véronique Kerlan and Pierre-Yves Salaun

and dTI, respectively ( 4 ). Moreover, in another meta-analysis, malignancy rate of fTI was as high as 34.6% (IC 95% 29.3–40.2) ( 5 ). Only few studies proposed a prospective design to investigate prevalence and malignancy rate of fTI in FDG PET

Open access

Eeva M Ryhänen, Ilkka Heiskanen, Harri Sintonen, Matti J Välimäki, Risto P Roine and Camilla Schalin-Jäntti

instrument might serve as a sensitive tool in assessing diffuse neurocognitive symptoms that might predict which patients benefit from surgery. In this single center study, we prospectively (before the operation, and at 6 and 12 months after surgery

Open access

Xiang Hu, Qiao Zhang, Tian-Shu Zeng, Jiao-Yue Zhang, Jie Min, Sheng-Hua Tian, Hantao Huang, Miaomiao Peng, Nan Zhang, Mengjiao Li, Qing Wan, Fei Xiao, Yan Chen, Chaodong Wu and Lu-Lu Chen

costs of different detection strategies in a cohort prospective study, although we tried to analyze these costs using excellent ideas and methods reported previously ( 20 , 21 , 22 , 23 ) with adjustment of discrepancy based on the economic and

Open access

Irvin M Modlin, Harry Aslanian, Lisa Bodei, Ignat Drozdov and Mark Kidd

PCR-based test to detect tumors in comparison with CgA with particular reference to the confounding variable of PPI usage. Methods Sample collection All samples were prospectively collected and analyzed according to a standard IRB protocol (Yale

Open access

Kathrin R Frey, Tina Kienitz, Julia Schulz, Manfred Ventz, Kathrin Zopf and Marcus Quinkler

follow-up of 5.5 years and to investigate if BMD alters after switching from immediate- to modified-release HC. Materials and methods Design and subjects This was a 5-year prospective and observational study including patients from one large

Open access

Ruth Therese Casey, Deborah Saunders, Benjamin George Challis, Deborah Pitfield, Heok Cheow, Ashley Shaw and Helen Lisa Simpson

malignancy, screening recommendations include annual radiological and biochemical surveillance ( 3 ). It is important to note, however, that recommended screening strategies are based on non-prospective data, and current clinical practice guidelines recommend

Open access

Peter L Kristensen, Ulrik Pedersen-Bjergaard, Rikke Due-Andersen, Thomas Høi-Hansen, Lise Grimmeshave, Valeriya Lyssenko, Leif Groop, Jens J Holst, Allan A Vaag and Birger Thorsteinsson

tested in a cohort of patients with type 1 diabetes previously followed for one year in an observational prospective study of the occurrence of severe hypoglycaemia ( 14 ). We also explored if variants of the TCF7L2 gene influence the secretion of