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Serum levels of neuron-specific enolase as a prognostic factor for disease progression in patients with GET/NEN in the pancreas and the small intestine

Malgorzata Fuksiewicz, Maria Kowalska, Agnieszka Kolasinska-Cwikla, and Beata Kotowicz

prostate cancer may be associated with a component of neuroendocrine cells in adenocarcinoma or with the initiated process of transformation of cancer cells in the neuroendocrine direction. Elevated NSE levels are among the unfavourable prognostic factors

Open access

Molecular prognostic factors in small-intestinal neuroendocrine tumours

K G Samsom, L M van Veenendaal, G D Valk, M R Vriens, M E T Tesselaar, and J G van den Berg

identify prognostic factors and new effective targets for precision medicine, the genomic landscape of SI-NETs has been under increasing investigation in recent years. LOH at chromosome 18 remains the most frequent genomic aberration (44–100%) found in SI

Open access

VDR mRNA overexpression is associated with worse prognostic factors in papillary thyroid carcinoma

June Young Choi, Jin Wook Yi, Jun Hyup Lee, Ra-Yeong Song, Hyeongwon Yu, Hyungju Kwon, Young Jun Chai, Su-jin Kim, and Kyu Eun Lee

and prognostic factors of PTC using ‘The Cancer Genome Atlas’ (TCGA) data. TCGA kindly provides multiplatform genomics data such as sequence and read count data from next-generation sequencing, copy-number analysis, methylomics and proteomics data ( 10

Open access

Risk stratification in differentiated thyroid cancer with RAI-avid lung metastases

Keiko Ohkuwa, Kiminori Sugino, Mitsuji Nagahama, Wataru Kitagawa, Kenichi Matsuzu, Akifumi Suzuki, Chisato Tomoda, Kiyomi Hames, Junko Akaishi, Chie Masaki, and Koichi Ito

prognosis in patients with RAI-avid lung metastasis were found ( 16 , 17 ). This study aimed to determine the clinical prognostic factors, including NLR, in RAI-avid lung metastasis cases and to attempt risk classification to identify future cases for TKI

Open access

Prognostic value of chromogranin A in patients with GET/NEN in the pancreas and the small intestine

Małgorzata Fuksiewicz, Maria Kowalska, Agnieszka Kolasińska-Ćwikła, Jarosław B Ćwikła, Łukasz Sawicki, Katarzyna Roszkowska-Purska, Joanna Drygiel, and Beata Kotowicz

, although in very small lesions, its level may be within the normal range ( 4 ). CgA in gastroenteropancreatic neuroendocrine neoplasms (GEP-NEN) can also serve as an independent prognostic factor for the evaluation of survival of patients. Previous studies

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Pleural effusion as a novel prognostic factor in metastatic thyroid carcinoma

David T Broome, Gauri B Gadre, Ehsan Fayazzadeh, James F Bena, and Christian Nasr

. Evaluating the prognostic factors associated with cancer-specific survival of differentiated thyroid carcinoma presenting with distant metastasis . Annals of Surgical Oncology 2013 20 1329 – 1335 . ( ) 7

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Metastatic neuroendocrine neoplasia treatments in patients over 70 years of age

Alberto Bongiovanni, Federica Recine, Flavia Foca, Valentina Fausti, Nada Riva, Greta Fabbri, Stefano Severi, Chiara Liverani, Alessandro De Vita, Chiara Spadazzi, Giacomo Miserocchi, Laura Mercatali, Dino Amadori, and Toni Ibrahim

-rank test. We used the Cox proportional hazards regression model to estimate hazard ratios (HRs) and relative 95% CI of potential clinical prognostic factors for OS. Important variables such as gender were included in multivariate analysis, even when

Open access

Tumor size and perineural invasion predict outcome of gastric high-grade neuroendocrine neoplasms

Qi Zhang, Hongshan Wang, Yanhong Xie, Suming Huang, Ke Chen, Botian Ye, Yupeng Yang, Jie Sun, Hongyong He, Fenglin Liu, Zhenbin Shen, Weidong Chen, Kuntang Shen, Yuan Ji, and Yihong Sun

Kaplan–Meier curves, and comparisons were performed using log-rank test. Cox proportional hazards regression model was used to identify the prognostic factors. Statistical significance was defined as a two-sided P < 0.05. Results

Open access

Development of predictive prognostic nomogram for NECs of rectum on population-based exploration

Yang Lv, Ning Pu, Wei-lin Mao, Wen-qi Chen, Huan-yu Wang, Xu Han, Yuan Ji, Lei Zhang, Da-yong Jin, Wen-Hui Lou, and Xue-feng Xu

primary cohort to identify related prognostic factors affecting overall survival (OS) of rectal NEC patients and to construct nomogram for prognosis prediction for these patients. Besides, the internal and external validations were also performed to

Open access

The age factor in survival of a population cohort of well-differentiated thyroid cancer

Andrea Mazurat, Andrea Torroni, Jane Hendrickson-Rebizant, Harbinder Benning, Richard W Nason, and K Alok Pathak

DSS were estimated by the Kaplan–Meier product limit method, and the effect of age and other prognostic factors on DSS was assessed using the log rank test for pairwise comparison. The competing influence of other causes of mortality, such as death due