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Marra Jai Aghajani, Tara Laurine Roberts, Tao Yang, Charles Eugenio McCafferty, Nicole J Caixeiro, Paul DeSouza and Navin Niles

N . The clinicopathological and prognostic significance of programmed cell death ligand 1 (PD-L1) expression in patients with non-medullary thyroid cancer: a systematic review and meta-analysis . Thyroid 2018 28 . ( https://doi.org/10.1089/thy

Open access

Shuang Ye, Yuanyuan Xu, Jiehao Li, Shuhui Zheng, Peng Sun and Tinghuai Wang

The role of G protein-coupled estrogen receptor 1 (GPER) signaling, including promotion of Ezrin phosphorylation (which could be activated by estrogen), has not yet been clearly identified in triple-negative breast cancer (TNBC). This study aimed to evaluate the prognostic value of GPER and Ezrin in TNBC patients. Clinicopathologic features including age, menopausal status, tumor size, nuclear grade, lymph node metastasis, AJCC TNM stage, and ER, PR and HER-2 expression were evaluated from 249 TNBC cases. Immunohistochemical staining of GPER and Ezrin was performed on TNBC pathological sections. Kaplan–Meier analyses, as well as logistic regressive and Cox regression model tests were applied to evaluate the prognostic significance between different subgroups. Compared to the GPER-low group, the GPER-high group exhibited higher TNM staging (P = 0.021), more death (P < 0.001), relapse (P < 0.001) and distant events (P < 0.001). Kaplan–Meier analysis showed that GPER-high patients had a decreased OS (P < 0.001), PFS (P < 0.001), LRFS (P < 0.001) and DDFS (P < 0.001) than GPER-low patients. However, these differences in prognosis were not statistically significant in post-menopausal patients (OS, P = 0.8617; PFS, P = 0.1905; LRFS, P = 0.4378; DDFS, P = 0.2538). There was a significant positive correlation between GPER and Ezrin expression level (R = 0.508, P < 0.001) and the effect of Ezrin on survival prognosis corresponded with GPER. Moreover, a multivariable analysis confirmed that GPER and Ezrin level were both significantly associated with poor DDFS (HR: 0.346, 95% CI 0.182–0.658, P = 0.001; HR: 0.320, 95% CI 0.162–0.631, P = 0.001). Thus, overexpression of GPER and Ezrin may contribute to aggressive behavior and indicate unfavorable prognosis in TNBC; this may correspond to an individual’s estrogen levels.

Open access

Huy Gia Vuong, Nguyen Phuoc Long, Nguyen Hoang Anh, Tran Diem Nghi, Mai Van Hieu, Le Phi Hung, Tadao Nakazawa, Ryohei Katoh and Tetsuo Kondo

2014 48 201 – 208 . ( https://doi.org/10.4132/KoreanJPathol.2014.48.3.201 ) 7 Ito Y Hirokawa M Miyauchi A Higashiyama T Kihara M Miya A. Prognostic significance of the proportion of tall cell components in papillary thyroid carcinoma . World

Open access

Guoquan Zhu, Yuying Deng, Liqin Pan, Wei Ouyang, Huijuan Feng, Juqing Wu, Pan Chen, Jing Wang, Yanying Chen and Jiaxin Luo

subgroup analysis, we compared the clinicopathologic and prognostic significance of bilateral PTC with that of unilateral PTC. Materials and methods Study design and samples In total, 2012 consecutive patients with differentiated thyroid

Open access

C Sui, Q He, R Du, D Zhang, F Li, G Dionigi, N Liang and H Sun

LiVolsi VA Mandel SJ Steward DL Tufano RP Tuttle RM & American Thyroid Association Surgical Affairs Committee’s Taskforce on Thyroid Cancer Nodal Surgery . The prognostic significance of nodal metastases from papillary thyroid carcinoma can be

Open access

Satoshi Inoue, Taichi Mizushima, Hiroki Ide, Guiyang Jiang, Takuro Goto, Yujiro Nagata, George J Netto and Hiroshi Miyamoto

experiments). * P  < 0.05 (vs control-shRNA). Expression of ATF2 in bladder cancer specimens and its prognostic significance Finally, we stained immunohistochemically for ATF2, p-ATF2 and p-ERK in the bladder TMAs consisting of 129 urothelial

Open access

Mubashir Mulla and Klaus-Martin Schulte

.12.6425 ). 36 Chow SM Law SC Chan JK Au SK Yau S Lau WH . Papillary microcarcinoma of the thyroid–Prognostic significance of lymph node metastasis and multifocality . Cancer 2003 98 31 – 40 . ( doi:10.1002/cncr.11442 ). 37 Lundgren CI Hall

Open access

Jes Sloth Mathiesen, Jens Peter Kroustrup, Peter Vestergaard, Per Løgstrup Poulsen, Åse Krogh Rasmussen, Ulla Feldt-Rasmussen, Sten Schytte, Stefano Christian Londero, Henrik Baymler Pedersen, Christoffer Holst Hahn, Jens Bentzen, Sören Möller, Mette Gaustadnes, Maria Rossing, Finn Cilius Nielsen, Kim Brixen, Christian Godballe and Danish Thyroid Cancer Group (DATHYRCA)

QH. Prognostic significance and optimal cutoff of age in medullary thyroid cancer . Oncotarget 2016 7 15937 – 15947 . ( https://doi.org/10.18632/oncotarget.7556 ) 26910117 8 Esfandiari NH Hughes DT Yin H Banerjee M Haymart MR. The effect

Open access

Renata C Scalco, Ericka B Trarbach, Edoarda V A Albuquerque, Thais K Homma, Thais H Inoue-Lima, Mirian Y Nishi, Berenice B Mendonca and Alexander A L Jorge

–Whitney rank-sum test or Kruskal–Wallis one-way ANOVA on ranks, as appropriate. To assess whether genetic variants had independent prognostic significance for outcomes, we performed linear and multiple-regression analyses adjusting for established influential

Open access

Marco Marino, Valentina Cirello, Valentina Gnarini, Carla Colombo, Elisa Pignatti, Livio Casarini, Chiara Diazzi, Vincenzo Rochira, Katia Cioni, Bruno Madeo, Cesare Carani, Manuela Simoni and Laura Fugazzola

Hsueh C Lin JD Chang YS Hsueh S Chao TC Yu JS Jung SM Tseng NM Sun JH Kuo SY . Prognostic significance of pituitary tumour-transforming gene-binding factor (PBF) expression in papillary thyroid carcinoma . Clinical Endocrinology