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Yang Lv, Ning Pu, Wei-lin Mao, Wen-qi Chen, Huan-yu Wang, Xu Han, Yuan Ji, Lei Zhang, Da-yong Jin, Wen-Hui Lou and Xue-feng Xu

clinically related to aggressive tumor behavior and devastating prognosis ( 4 ). However, study has ( 5 ) proved that NECs could also demonstrate heterogeneous oncological behavior with a relatively wide spectrum of differentiation degree. Increasing evidence

Open access

Wentao Zhou, Tiantao Kuang, Xu Han, Wenqi Chen, Xuefeng Xu, Wenhui Lou and Dansong Wang

, histological features and biological behaviors. The long-term prognosis of pNEN is much better than pancreatic adenocarcinomas with a 5-year survival rate ranging from 60% to 90% ( 4 ). Nevertheless, a certain portion of pNEN patients could advance rapidly even

Open access

Shuang Ye, Yuanyuan Xu, Jiehao Li, Shuhui Zheng, Peng Sun and Tinghuai Wang

common therapeutic targets, TNBCs are associated with the worst prognosis and one of the highest risks of metastasis among all subtypes of breast cancer ( 2 , 3 ). Further, several population-based studies have shown that TNBC often presents at a

Open access

Andrea Mazurat, Andrea Torroni, Jane Hendrickson-Rebizant, Harbinder Benning, Richard W Nason and K Alok Pathak

Hürthle cell variants, account for over 90% of all thyroid malignancies (22, 23) . Our analysis of all consecutive WDTC seen between 1970 and 2010 confirmed the excellent prognosis of WDTC with a DSS of 95.4% (95% CI, 94.2–96.3%) at 10 years. WDTC

Open access

Simon Schimmack, Yongchao Yang, Klaus Felix, Markus Herbst, Yixiong Li, Miriam Schenk, Frank Bergmann, Thilo Hackert and Oliver Strobel

, 4 ). Since prognosis varies widely between individual pNENs ( 5 ), there is a critical need to better define the molecular features associated with prognosis in these tumors. Recently, elevated pre-operative C-reactive protein (CRP) values have

Open access

Catarina Tavares, Maria João Coelho, Catarina Eloy, Miguel Melo, Adriana Gaspar da Rocha, Ana Pestana, Rui Batista, Luciana Bueno Ferreira, Elisabete Rios, Samia Selmi-Ruby, Bruno Cavadas, Luísa Pereira, Manuel Sobrinho Simões and Paula Soares

behavior and prognosis. Some studies tried to understand if NIS immunohistochemical expression in thyroid primary tumors would be helpful in predicting 131 I uptake in recurrences and distant metastases. Although positive NIS immunostaining in primary

Open access

Yang Lv, Xu Han, Chunyan Zhang, Yuan Fang, Ning Pu, Yuan Ji, Dansong Wang, Xu Xuefeng and Wenhui Lou

surgical/needled specimen can give rise to the prognosis prediction and nonoperative management guidance to some extents, but this is usually based on a fixed small biopsy sample that may not reflect the heterogeneity present in advanced tumors ( 2

Open access

Xu Han, Xuefeng Xu, Hongyun Ma, Yuan Ji, Dansong Wang, Tiantao Kuang, Wenchuan Wu, Bin Song, Gang Li, Gang Jin and Wenhui Lou

into small cell and large cell subtype, and were associated with highly aggressive behavior and dismal prognosis ( 6 ). However, recent literature indicates that some G3 pNENs containing noticeably different genetic mutational profile have well

Open access

K G Samsom, L M van Veenendaal, G D Valk, M R Vriens, M E T Tesselaar and J G van den Berg

of unravelling the molecular events underlying NET tumorigenesis, facilitating the identification of novel therapeutic targets, rational (targeted) therapy management strategies and to improve prognosis. Recently, whole-genome sequencing of primary

Open access

Huy Gia Vuong, Nguyen Phuoc Long, Nguyen Hoang Anh, Tran Diem Nghi, Mai Van Hieu, Le Phi Hung, Tadao Nakazawa, Ryohei Katoh and Tetsuo Kondo

aggressive and associated with a poor prognosis ( 2 ). Criteria for TCVPTC was first proposed in 1976 by Hawk and Hazard ( 3 ). In the previous WHO 2004 classification, however, the morphological criterion for the diagnosis of TCVPTC was vague: ‘The TCV is