Arno Téblick
Arno Téblick
Clinical Division and Laboratory of Intensive Care Medicine, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium
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Ilse Vanhorebeek
Ilse Vanhorebeek
Clinical Division and Laboratory of Intensive Care Medicine, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium
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Inge Derese
Inge Derese
Clinical Division and Laboratory of Intensive Care Medicine, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium
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An Jacobs
An Jacobs
Clinical Division and Laboratory of Intensive Care Medicine, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium
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Renata Haghedooren
Renata Haghedooren
Clinical Division and Laboratory of Intensive Care Medicine, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium
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Sofie Maebe
Sofie Maebe
Clinical Division and Laboratory of Intensive Care Medicine, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium
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Gerdien A Zeilmaker-Roest
Gerdien A Zeilmaker-Roest
Department of Neonatal & Pediatric Intensive Care, Division of Pediatric Intensive Care, Erasmus MC – Sophia Children’s Hospital, Rotterdam, the Netherlands
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Enno D Wildschut
Enno D Wildschut
Department of Neonatal & Pediatric Intensive Care, Division of Pediatric Intensive Care, Erasmus MC – Sophia Children’s Hospital, Rotterdam, the Netherlands
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Lies Langouche
Lies Langouche
Clinical Division and Laboratory of Intensive Care Medicine, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium
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Greet Van den Berghe
Greet Van den Berghe
Clinical Division and Laboratory of Intensive Care Medicine, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium
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of the ACTH precursor, pro-opiomelanocortin (POMC) ( 1 ). Results from our mechanistic animal study suggested that during sepsis-induced critical illness, preserved hypothalamic corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP
Tatiana V Novoselova
Tatiana V Novoselova
Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London, London, UK
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Peter J King
Peter J King
Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London, London, UK
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Leonardo Guasti
Leonardo Guasti
Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London, London, UK
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Louise A Metherell
Louise A Metherell
Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London, London, UK
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Adrian J L Clark
Adrian J L Clark
Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London, London, UK
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Li F Chan
Li F Chan
Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London, London, UK
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). ACTH, a 39 amino acid peptide, is produced by cleavage of its precursor protein, pro-opiomelanocortin (POMC). Other cleavage products of POMC include α-, β-, γ-melanocyte-stimulating hormones (MSH), β-endorphin, N-terminal peptide of pro-opiomelanocortin
Rachel Forfar
Rachel Forfar
Centre for Therapeutics Discovery, LifeArc, Accelerator Building, Open Innovation Campus, Stevenage, UK
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Mashal Hussain
Mashal Hussain
Centre for Endocrinology, William Harvey Research Institute, Queen Mary University of London, London, UK
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Puneet Khurana
Puneet Khurana
Centre for Therapeutics Discovery, LifeArc, Accelerator Building, Open Innovation Campus, Stevenage, UK
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Jennifer Cook
Jennifer Cook
Centre for Therapeutics Discovery, LifeArc, Accelerator Building, Open Innovation Campus, Stevenage, UK
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Steve Lewis
Steve Lewis
Centre for Therapeutics Discovery, LifeArc, Accelerator Building, Open Innovation Campus, Stevenage, UK
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Dillon Popat
Dillon Popat
Centre for Endocrinology, William Harvey Research Institute, Queen Mary University of London, London, UK
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David Jackson
David Jackson
Centre for Endocrinology, William Harvey Research Institute, Queen Mary University of London, London, UK
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Ed McIver
Ed McIver
Centre for Therapeutics Discovery, LifeArc, Accelerator Building, Open Innovation Campus, Stevenage, UK
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Jeff Jerman
Jeff Jerman
Centre for Therapeutics Discovery, LifeArc, Accelerator Building, Open Innovation Campus, Stevenage, UK
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Debra Taylor
Debra Taylor
Centre for Therapeutics Discovery, LifeArc, Accelerator Building, Open Innovation Campus, Stevenage, UK
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Adrian JL Clark
Adrian JL Clark
Centre for Endocrinology, William Harvey Research Institute, Queen Mary University of London, London, UK
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Li F Chan
Li F Chan
Centre for Endocrinology, William Harvey Research Institute, Queen Mary University of London, London, UK
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Introduction The melanocortins, comprising the α-, β-, and γ-melanocyte-stimulating hormones (MSHs) and adrenocorticotropic hormone (ACTH), are a family of peptide hormones cleaved from the prohormone pro-opiomelanocortin that have a diverse
Ming Zhu
Ming Zhu
Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine, Shanghai East Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, China
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Bingxin Xu
Bingxin Xu
Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine, Shanghai East Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, China
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Meng Wang
Meng Wang
Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine, Shanghai East Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, China
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Shangyun Liu
Shangyun Liu
Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine, Shanghai East Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, China
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Yue Zhang
Yue Zhang
Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine, Shanghai East Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, China
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Chao Zhang
Chao Zhang
Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine, Shanghai East Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, China
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for pigmentation, MC2R for adrenocortical steroidogenesis, MC3R for energy homeostasis, MC4R for appetite control and MC5R for exocrine secretion ( 1 ). Four pro-opiomelanocortin (POMC)-derived natural agonists (α-, β-, γ-MSH and ACTH) and two
Ying Xu
Ying Xu
Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine, Shanghai East Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, China
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Lei Li
Lei Li
Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine, Shanghai East Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, China
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Jihong Zheng
Jihong Zheng
Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine, Shanghai East Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, China
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Meng Wang
Meng Wang
Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine, Shanghai East Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, China
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Bopei Jiang
Bopei Jiang
Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine, Shanghai East Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, China
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Yue Zhai
Yue Zhai
Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine, Shanghai East Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, China
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Liumei Lu
Liumei Lu
Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine, Shanghai East Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, China
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Cong Zhang
Cong Zhang
Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine, Shanghai East Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, China
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Zhe Kuang
Zhe Kuang
Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine, Shanghai East Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, China
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Xiaomei Yang
Xiaomei Yang
Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine, Shanghai East Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, China
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Li-Na Jin
Li-Na Jin
Department of Hematology, Changzheng Hospital, Naval Medical University, Shanghai, China
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Gufa Lin
Gufa Lin
Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine, Shanghai East Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, China
Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Orthopaedic Department of Tongji Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, China
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Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Orthopaedic Department of Tongji Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, China
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Chao Zhang
Chao Zhang
Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine, Shanghai East Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, China
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Introduction The melanocortin receptors (MCRs), a subfamily of the seven-transmembrane class A G protein-coupled receptors, can be selectively regulated by pro-opiomelanocortin (POMC)-derived ligands (i.e. adrenocorticotrophic hormone (ACTH
Gavin P Vinson
Gavin P Vinson
School of Biological and Chemical Sciences, Queen Mary University of London, London E1 4NS, UK
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Caroline H Brennan
Caroline H Brennan
School of Biological and Chemical Sciences, Queen Mary University of London, London E1 4NS, UK
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Kreek MJ . Hypothalamic–pituitary–adrenal activity and pro-opiomelanocortin mRNA levels in the hypothalamus and pituitary of the rat are differentially modulated by acute intermittent morphine with or without water restriction stress . Journal of
Lin Ji
Lin Ji
Department of Cell Biology & Medical Genetics, School of Medicine, Shenzhen University, Shenzhen, China
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Huan-Tong Wu
Huan-Tong Wu
Beijing Engineering Research Center of Food Environment and Health, College of Life & Environmental Sciences, Minzu University of China, Beijing, China
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Xiao-Yan Qin
Xiao-Yan Qin
Beijing Engineering Research Center of Food Environment and Health, College of Life & Environmental Sciences, Minzu University of China, Beijing, China
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Rongfeng Lan
Rongfeng Lan
Department of Cell Biology & Medical Genetics, School of Medicine, Shenzhen University, Shenzhen, China
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, promelanin-concentrating hormone, progastrin and pro-opiomelanocortin (POMC), as well as reduced levels of bioactive peptides such as insulin, adrenocorticotropic hormone (ACTH), neurotensin, cholecystokinin (CCK) and gastrin in Cpe fat /Cpe fat mice
Arno Téblick
Arno Téblick
Clinical Division and Laboratory of Intensive Care Medicine, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium
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Lies Langouche
Lies Langouche
Clinical Division and Laboratory of Intensive Care Medicine, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium
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Greet Van den Berghe
Greet Van den Berghe
Clinical Division and Laboratory of Intensive Care Medicine, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium
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outcome of prolonged critically ill patients are lacking. The adrenal axis during health Pro-opiomelanocortin (POMC), synthesized in the corticotropic cells of the pituitary, is spliced to adrenocorticotropic hormone (ACTH) by proteolytic cleavage
