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Cheng Han Ng, Yip Han Chin, Marcus Hon Qin Tan, Jun Xuan Ng, Samantha Peiling Yang, Jolene Jiayu Kiew, and Chin Meng Khoo

Introduction Primary hyperparathyroidism (PHPT) is a common endocrine disorder that is caused by excessive or inappropriate parathyroid hormone (PTH) secretion with simultaneous derangement of both phosphate and calcium metabolism. PHPT is

Open access

Luchuan Li, Baoyuan Li, Bin Lv, Weili Liang, Binbin Zhang, Qingdong Zeng, Andrew G Turner, and Lei Sheng

Introduction Primary hyperparathyroidism (PHPT) is a common endocrine disorder, having a prevalence of 0.04–0.1% in the general population ( 1 ). The principal role of parathyroid hormone (PTH) is to maintain (raise) blood calcium levels in

Open access

Anna Eremkina, Julia Krupinova, Ekaterina Dobreva, Anna Gorbacheva, Ekaterina Bibik, Margarita Samsonova, Alina Ajnetdinova, and Natalya Mokrysheva

Introduction Primary hyperparathyroidism (PHPT) and malignancy are the two most common causes of hypercalcemia ( 1 ). Hypercalcemic crisis (HC) is an uncommon, but severe complication of PHPT more specifically for parathyroid cancer ( 2 ). The

Open access

Kristin Godang, Karolina Lundstam, Charlotte Mollerup, Stine Lyngvi Fougner, Ylva Pernow, Jörgen Nordenström, Thord Rosén, Svante Jansson, Mikael Hellström, Jens Bollerslev, Ansgar Heck, and the SIPH Study Group

Introduction Primary hyperparathyroidism (PHPT) is a common endocrine disease ( 1 ) and is characterized by hyperactivity in one or several parathyroid glands, raised levels of parathyroid hormone (PTH) and altered calcium homeostasis with

Open access

Daniel Bell, Julia Hale, Cara Go, Ben G Challis, Tilak Das, Brian Fish, and Ruth T Casey

Introduction Primary hyperparathyroidism (pHPT) is a common endocrine disorder with a prevalence of 1–4 per 1000 and a 3 to 1 female to male ratio ( 1 ). It is characterised by inappropriate and excessive secretion of parathyroid hormone (PTH

Open access

Cristina Lamas, Elena Navarro, Anna Casterás, Paloma Portillo, Victoria Alcázar, María Calatayud, Cristina Álvarez-Escolá, Julia Sastre, Evangelina Boix, Lluis Forga, Almudena Vicente, Josep Oriola, Jordi Mesa, and Nuria Valdés

Introduction Multiple endocrine neoplasia type 1 (MEN1) syndrome is a rare hereditary disease, with an estimated prevalence of 0.15–0.30 cases per 1000 in general population ( 1 , 2 ). Primary hyperparathyroidism (PHPT) is its most common

Open access

Magdaléna Fořtová, Lenka Hanousková, Martin Valkus, Jana Čepová, Richard Průša, and Karel Kotaška

Introduction About 80–90% of primary hyperparathyroidism (pHPT) cases are caused by parathyroid adenoma. Long-term increased parathyroid hormone (PTH) secretion leads to a generalized disorder of calcium, phosphate and bone metabolism. The

Open access

Marlena Mueller, Fahim Ebrahimi, Emanuel Christ, Christian Andreas Nebiker, Philipp Schuetz, Beat Mueller, and Alexander Kutz

Introduction Primary hyperparathyroidism (pHPT) is an increasingly prevalent endocrinopathy, predominantly affecting elderly women ( 1 , 2 ). Incidence rates increase with age, peaking in age-groups above 60 years, and varying with regard to

Open access

Yuan Liu, Siyi Guo, Jinsong Wu, Rongai Wang, Jinbo Liu, Yan Liu, Bin Lv, Nan Liu, Ling Jiang, and Xiaoli Zhang

Introduction In the 1970s, due to the popularization of serum calcium (Ca) examination, a novel type of primary hyperparathyroidism (PHPT) called asymptomatic PHPT (aPHPT) emerged. It lacks the typical clinical symptoms caused by excessive

Open access

Elizaveta Mamedova, Natalya Mokrysheva, Evgeny Vasilyev, Vasily Petrov, Ekaterina Pigarova, Sergey Kuznetsov, Nikolay Kuznetsov, Liudmila Rozhinskaya, Galina Melnichenko, Ivan Dedov, and Anatoly Tiulpakov

Introduction Primary hyperparathyroidism (PHPT) is a common endocrine disorder, predominantly in postmenopausal women ( 1 ). Nevertheless, PHPT can occur at any age, and its incidence increases steadily after age 25 years in both sexes ( 2