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Anette Lundqvist, Herbert Sandström and Torbjörn Bäckström

Introduction Maternal obesity and excessive weight gain during pregnancy is a condition that increases the risk of several complications for both the mother and the growing fetus, with a risk that the fetus will suffer from a suboptimal

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Kathryn L Gatford, Beverly S Muhlhausler, Lili Huang, Pamela Su-Lin Sim, Claire T Roberts, Johannes D Velhuis and Chen Chen

Introduction Successful pregnancy requires major physiological adaptations in the mother to support pregnancy, and the attachment, implantation, growth and function of the placental interface between mother and foetus ( 1 ). Growth hormone (GH

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Caio Jordão Teixeira, Junia Carolina Santos-Silva, Dailson Nogueira de Souza, Alex Rafacho, Gabriel Forato Anhe and Silvana Bordin

hyperglycemia in nondiabetic women ( 3 , 4 ). Concordantly, experiments with rats showed that exposure to dexamethasone (DEX) during the last third of pregnancy impaired maternal glucose-induced insulin secretion in vivo , leading to glucose intolerance prior

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Yessica Agudelo-Zapata, Luis Miguel Maldonado-Acosta, Héctor Fabio Sandoval-Alzate, Natalia Elvira Poveda, María Fernanda Garcés, Jonathan Alexander Cortés-Vásquez, Andrés Felipe Linares-Vaca, Carlos Alejandro Mancera-Rodríguez, Shahar Alexandra Perea-Ariza, Karen Yuliana Ramírez-Iriarte, Camilo Andrés Castro-Saldarriaga, Juan Manuel Arteaga-Diaz, Roberto Franco-Vega, Edith Ángel-Müller, Arturo José Parada-Baños and Jorge E Caminos

Introduction There is a high prevalence of 25-hydroxyvitamin D (25OHD) deficiency during pregnancy ( 1 ). In the United States, a prevalence of 33% has been reported, while in countries such as Turkey, the prevalence reaches 90% ( 1 ). 25OHD

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Caroline Serrano-Nascimento, Rafael Barrera Salgueiro, Kaio Fernando Vitzel, Thiago Pantaleão, Vânia Maria Corrêa da Costa and Maria Tereza Nunes

thyroid disorders ( 10 , 11 , 12 ). It is worth noting that the daily requirement of iodine consumption increases to 200–250 µg during pregnancy and lactation, in order to guarantee normal maternal thyroid function ( 13 ). Indeed, adequate maternal TH

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Elizabeth Micks, Greta B Raglan and Jay Schulkin

pregnancies in the USA are unintended (1, 2, 3) . About half of women in the USA will have an unintended pregnancy by age 45, and one in three will have an abortion (4) . Worldwide, the situation is more dire as women with unintended pregnancy often do not

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Jian Ding, Yan Kang, Yuqin Fan and Qi Chen

Introduction Preeclampsia (PE) is a severe disease that manifests in multiple systems, and uniquely occurs during pregnancy, usually after 20 weeks of gestation ( 1 ). PE remains the leading cause of mortality and morbidity during pregnancy

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Verônica Carneiro Borges Mioto, Ana Carolina de Castro Nassif Gomes Monteiro, Rosalinda Yossie Asato de Camargo, Andréia Rodrigues Borel, Regina Maria Catarino, Sergio Kobayashi, Maria Cristina Chammas and Suemi Marui

neurological development and pregnancy outcomes ( 1 , 2 ). During pregnancy, daily iodine requirement increases by nearly 50% because of an increase in renal iodine excretion, increased thyroid hormone production and foetal iodine requirements ( 3 ). In

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J A Tamblyn, C Jenkinson, D P Larner, M Hewison and M D Kilby

Introduction Pre-eclampsia (PET) is a pregnancy-specific, multisystem syndrome with endothelial dysfunction and presenting with hypertension and pathologic renal protein excretion. Complicating up to 8% of pregnancies ( 1 , 2 , 3 ), PET is

Open access

K L Gatford, G K Heinemann, S D Thompson, J V Zhang, S Buckberry, J A Owens, G A Dekker, C T Roberts and on behalf of the SCOPE Consortium

women (6, 7) , but whether IGF2 remains similar between sexes throughout ageing is unknown. IGF abundance is also altered by pregnancy. Variable changes in circulating IGF1 during the first two trimesters of human pregnancy have been reported, with