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Early arteriosclerosis and its risk factors in subjects with prediabetes and new-onset diabetes

Xiaoli Liu, Lanxiang Liu, Rui Wang, Xiaojiao Jia, Binbin Liu, Ning Ma, and Qiang Lu

prediabetes and new-onset diabetes. As a basic characteristic of type 2 diabetes mellitus (T2DM), insulin resistance plays an important role in the development and progression of arteriosclerosis. Insulin resistance is present in prediabetes, and populations

Open access

Not performing an OGTT results in underdiagnosis, inadequate risk assessment and probable cost increases of (pre)diabetes in Han Chinese over 40 years: a population-based prospective cohort study

Xiang Hu, Qiao Zhang, Tian-Shu Zeng, Jiao-Yue Zhang, Jie Min, Sheng-Hua Tian, Hantao Huang, Miaomiao Peng, Nan Zhang, Mengjiao Li, Qing Wan, Fei Xiao, Yan Chen, Chaodong Wu, and Lu-Lu Chen

.1% may have had prediabetes, an important risk factor of overt diabetes and cardiovascular disease ( 2 ). Diabetes leads to complications that cause profound psychological and physical distress, putting a huge burden on health care systems ( 3 , 4 ). The

Open access

Relation of prediabetes and type 2 diabetes mellitus to thyroid cancer

T Grimmichova, M Haluzik, K Vondra, P Matucha, and M Hill

department from primary care mainly due to suspicions of thyropathy, other endocrinopathy or diabetes. Patients with negative history of prediabetes or diabetes were screened for diabetes following the standards of the American Diabetes Association and the

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Pancreatic and gut hormones as predictors of new-onset prediabetes after non-necrotising acute pancreatitis: a prospective longitudinal cohort study

Sakina H Bharmal, Wandia Kimita, Juyeon Ko, and Maxim S Petrov

increases with time ( 8 ), there is a need for early identification of high-risk individuals to introduce targeted strategies for preventing and managing this sequela of AP. Prediabetes is one of the most prominent risk factors for new-onset diabetes

Open access

The association of adiponectin with risk of pre-diabetes and diabetes in different subgroups: cluster analysis of a general population in south China

Xun Gong, Lili You, Feng Li, Qingyu Chen, Chaogang Chen, Xiaoyun Zhang, Xiuwei Zhang, Wenting Xuan, Kan Sun, Guojuan Lao, Chuan Wang, Yan Li, Mingtong Xu, Meng Ren, and Li Yan

-sectional study, which included 75,880 Chinese adults showed that the prevalence of total diabetes and pre-diabetes, according to the American Diabetes Association (ADA) criteria, reached 12.8 and 35.2%, respectively ( 2 ). Moreover, 70% of patients with pre-diabetes

Open access

Habitual physical activity is associated with lower fasting and greater glucose-induced GLP-1 response in men

Charlotte Janus, Dorte Vistisen, Hanan Amadid, Daniel R Witte, Torsten Lauritzen, Søren Brage, Anne-Louise Bjerregaard, Torben Hansen, Jens J Holst, Marit E Jørgensen, Oluf Pedersen, Kristine Færch, and Signe S Torekov

responsible for up to 70% of the postprandial insulin response in healthy individuals whilst being severely impaired in patients with prediabetes and T2D ( 5 , 6 ). Furthermore, GLP-1 responses are lower in individuals with overweight and obesity

Open access

Cardiovascular risk factors in mild adrenal autonomous cortisol secretion in a Caucasian population

Agnieszka Adamska, Vitalii Ulychnyi, Katarzyna Siewko, Anna Popławska-Kita, Małgorzata Szelachowska, Marcin Adamski, Angelika Buczyńska, and Adam Jacek Krętowski

patient evaluation including comorbidities and life expectancy is essential to reach treatment decisions ( 11 ). The classic cardiovascular risk factors are obesity, type 2 diabetes mellitus (T2DM), prediabetes (PD), hypertension, hyperlipidaemia and

Open access

Gut microbiota and diet in patients with different glucose tolerance

Lilit Egshatyan, Daria Kashtanova, Anna Popenko, Olga Tkacheva, Alexander Tyakht, Dmitry Alexeev, Natalia Karamnova, Elena Kostryukova, Vladislav Babenko, Maria Vakhitova, and Sergey Boytsov

deviation degree Patients without glucose intolerance, who had passed the preventive outpatient examination. Patients with prediabetes (preD) (impaired fasting glucose or impaired glucose tolerance or the level of HbA1c from 5.7 to 6.5%. Patients with newly

Open access

Long-term efficacy of metformin in overweight-obese PCOS: longitudinal follow-up of retrospective cohort

Mojca Jensterle, Nika Aleksandra Kravos, Simona Ferjan, Katja Goricar, Vita Dolzan, and Andrej Janez


Long-term efficacy of metformin in polycystic ovarian syndrome (PCOS) apart from in those with impaired glucose tolerance or diabetes remains unproven. We aimed to evaluate the impact of metformin in overweight-obese patients with PCOS and normal baseline glycemic homeostasis.


A 10-year longitudinal follow-up of a retrospective cohort comprising 159 patients with PCOS defined by Rotterdam criteria, BMI ≥25 kg/m2 and normal initial glucose homeostasis (age 28.4 ± 6.4 years, BMI 34.9 ± 6.6 kg/m2) that had been receiving metformin 1000 mg BID. Collection data contained 6085 time-points including anthropometric, hormonal and metabolic parameters.


After the first year body mass (BM) decreased for 3.9 ± 6.8 kg (P < 0.001) and remained stable during the following 3 years. Menstrual frequency (MF) increased to 3.0 ± 3.9 bleeds/year (P < 0.001) after first year to over 11 bleeds/year in the following years. The total testosterone and androstenedione decreased to 15.4 ± 47.9% and 11.3 ± 46.4% within first year, with further decrease in total testosterone and androstenedione to 37.8 ± 61.8 and 24.8 ± 40.5% at the fifth year of the follow-up. The total conversion rate to prediabetes and diabetes was extremely low throughout observation period. Less than 25% of patients continued with metformin for more than 5 years with further dropout to only 6% on metformin therapy at the tenth year of follow-up.


Long-term metformin treatment of overweight-obese women with PCOS and normal baseline glycemic homeostasis resulted in reduction and stabilization of BM, improvements of MF and androgen profile and low conversion rate to diabetes.

Open access

Association of fasting plasma glucose change trajectory and risk of hypertension: a cohort study in China

Yanmei Lou, Yanyan Zhang, Ping Zhao, Pei Qin, Changyi Wang, Jianping Ma, Xiaolin Peng, Hongen Chen, Dan Zhao, Shan Xu, Li Wang, Ming Zhang, Dongsheng Hu, and Fulan Hu

), while the presence of diabetes significantly increases the incidence of hypertension ( 9 ). The precursors to diabetes and hypertension remain unknown; however, a meta-analysis indicated that prediabetes was associated with an increased risk of