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Introduction Polyuria (diuresis >3 l/day) in the absence of common causes, such as hypercalcemia, hyperglycemia, or relief of urinary tract obstruction, can be caused by diabetes insipidus (DI) or primary polydipsia (PP, also referred to as
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Introduction Polyuria polydipsia syndrome is a common problem in clinical practice with the two main entities being primary polydipsia and central diabetes insipidus ( 1 ). While the pathomechanism of central diabetes insipidus is well known
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Introduction Disturbances in water homeostasis are highly prevalent and the underlying causes are not always easy to identify. In particular, the differential diagnosis in patients with the polyuria–polydipsia syndrome (PPS) is challenging ( 1
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deficiency results in uncontrolled diuresis. Complete deficiency can lead to polyuria exceeding 10 L/24 h. Given a functioning thirst mechanism and free access to water, patients with CDI can normally maintain adequate fluid balance through increased drinking
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presentation 610 91/610 (14.9%) Polyuria at presentation 610 95/610 (15.6%) Bone/joint pain at presentation 610 168/610 (27.5%) Previous fracture at presentation 611 100/611 (16.4%) Constipation/abdominal pain at
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infusions for the differential diagnosis of DI ( 11 ), we aimed to investigate the course of plasma potassium levels during a standardized hypertonic saline infusion test with 3% saline in a large cohort of healthy volunteers and patients with polyuria
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change, it is instructive to review the historical context for the name of diabetes insipidus. The polyuria and polydipsia of diabetes were first described by Demetrius of Apameia (1st–2nd century BC), who used the term ‘diabetes’, meaning ‘passing water
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correction due to the risk of dysrhythmia and coma Clinical features of hypercalcaemia Polyuria and thirst Anorexia, nausea and constipation Mood disturbance, cognitive dysfunction, confusion and coma Renal impairment Shortened QT interval
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Muscle weakness, carpopedal spasm/tetany, muscle stiffness/pain, arthralgia, thirst, paresthesias, palpitations 3 M 20 17 115/70 423 Het Thr304Met Muscle weakness, carpopedal spasm/tetany, nocturia, polyuria, thirst, paresthesias
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by hypercalcemia. Typical symptoms are mainly musculoskeletal (bone pain, fracture), urological (urolithiasis, polyuria, and hematuria), gastrointestinal (nausea, vomiting, and loss of appetite), and neuropsychiatric (fatigue, dizziness, and