Endocrinology Department, University Hospital in Krakow, Krakow, Poland
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Endocrinology Department, University Hospital in Krakow, Krakow, Poland
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Endocrinology Department, University Hospital in Krakow, Krakow, Poland
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are the most typical causes of brain injuries. Pituitary dysfunction resulting as a consequence of brain injury is not a new phenomenon – the first article illustrating the matter was published in 1918 ( 8 ). Nowadays, the topic is gaining more and
Department of Emergency Medicine, Landspitali – The National University Hospital of Iceland, Reykjavik, Iceland
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Department of Psychology, School of Social Sciences, Reykjavik University, Reykjavik, Iceland
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School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland
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Department of Medicine, Landspitali – The National University Hospital of Iceland, Reykjavik, Iceland
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( 43 ). The aim of this study was to explore pituitary dysfunction (PD) including HP in female athletes following mTBI in sport and, to the best of our knowledge, it is the first study to do so. Materials and methods Study design and subjects
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-prevalence of pituitary dysfunction (PD) with stroke. As the symptomatology of poststroke symptoms such as fatigue and cognitive disturbances overlap with that of PD, the question raises whether there could be a causal relationship. If poststroke PD plays a role
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Objective: Children with a supratentorial midline low grade glioma (LGG) may be at risk for impaired bone health due to hypothalamic-pituitary dysfunction, obesity, exposure to multiple treatment modalities, and/or decreased mobility. The presence of impaired bone health and/or its severity in this population has been understudied. We aimed to identify the prevalence and risk factors for bone problems in children with supratentorial midline LGG.
Design and Methods: A retrospective study was performed in children with supratentorial midline (suprasellar or thalamic) LGG between 1-1-2003 and 1-1-2022, visiting the Princess Máxima Center for Pediatric Oncology. Impaired bone health was defined as presence of vertebral fractures and/or very low bone mineral density (BMD).
Results: In total, 161 children were included, with a median age at tumor diagnosis of 4.7 years (range 0.1 – 17.9) and a median follow-up of 6.1 years (range 0.1 – 19.9). Five patients (3.1 %) had vertebral fractures. In 99 patients BMD was assessed either by Dual Energy X ray Absorptiometry (n=12) or Bone Health Index (n=95); 34 patients (34.3%) had a low BMD (≤ -2.0). Impaired visual capacity was associated with bone problems in multivariable analysis (OR 6.63, 95% CI 1.83 – 24.00, p = 0.004).
Conclusions: In this retrospective evaluation, decreased BMD was prevalent in 34.3% of children with supratentorial midline LGG. For the risk to develop bone problems visual capacity seems highly relevant. Surveillance of bone health must be an aspect for awareness in the care and follow-up of children with a supratentorial midline LGG.
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pituitary dysfunction, NAFLD was diagnosed with a median of 3 years after the diagnosis of pituitary dysfunction, with a high prevalence of cirrhosis and liver-related death (4) . Given the relatively young age of the subjects studied in this work, one
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Department of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands
Endo-ERN European Reference Network on Rare endocrine conditions
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Endo-ERN European Reference Network on Rare endocrine conditions
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Division of Endocrinology and Metabolism, Center for Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, Athens, Greece
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detrimental effects on the quality of life. Patients with HD may experience disturbed hunger-satiety and thirst feelings, decreased energy expenditure, behavioral problems, disturbed circadian rhythm, temperature dysregulation and pituitary dysfunction
BARROW Neurological Institute at Phoenix Children’s Hospital, Phoenix, Arizona, USA
Department of Child Health, University of Arizona College of Medicine – Phoenix, Phoenix, Arizona, USA
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Department of Child Health, University of Arizona College of Medicine – Phoenix, Phoenix, Arizona, USA
Department of Biology and Biochemistry, University of Bath, UK
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Department of Child Health, University of Arizona College of Medicine – Phoenix, Phoenix, Arizona, USA
Department of Biology and Biochemistry, University of Bath, UK
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Department of Child Health, University of Arizona College of Medicine – Phoenix, Phoenix, Arizona, USA
School of Biological and Health Systems Engineering, Arizona State University, Tempe, Arizona, USA
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BARROW Neurological Institute at Phoenix Children’s Hospital, Phoenix, Arizona, USA
Department of Child Health, University of Arizona College of Medicine – Phoenix, Phoenix, Arizona, USA
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BARROW Neurological Institute at Phoenix Children’s Hospital, Phoenix, Arizona, USA
Department of Child Health, University of Arizona College of Medicine – Phoenix, Phoenix, Arizona, USA
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23 928 – 942 . ( doi:10.1089/neu.2006.23.928 ) 13 Zaben M El Ghoul W Belli A. Post-traumatic head injury pituitary dysfunction . Disability and Rehabilitation 2013 35 522 – 525 . ( doi:10.3109/09638288.2012.697252 ) 14 Webb
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, 10 , 11 , 12 ). Pituitary dysfunction is variable but ACTH deficiency seems essentially universal ( 13 , 14 ). In contrast, the PD-1 and PD-L1 inhibitors result less commonly in pituitary involvement (~1%), and are reported to result in isolated
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Division of Cardiovascular and Diabetes Research, Leeds Institute of Cardiovascular and Metabolic Medicine (LICAMM), University of Leeds, Leeds, UK
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performed in adult survivors of non-pituitary brain tumours showed a comparatively higher prevalence of pituitary dysfunction of 88.8% after a median follow-up of 8 years. For individual axes, growth hormone deficiency (GHD) was the most frequent (86
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Green Templeton College, University of Oxford, Oxford, UK
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(acromegaly or Cushing’s syndrome) ( 5 , 6 , 7 ); however, posterior pituitary dysfunction (diabetes insipidus (DI)) is virtually never seen prior to surgery ( 4 ). PPTs are usually seen as suprasellar or sellar-suprasellar masses with no pathognomonic