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G Giuffrida, F Ferraù, R Laudicella, O R Cotta, E Messina, F Granata, F F Angileri, A Vento, A Alibrandi, S Baldari and S Cannavò

Introduction Pituitary tumors (PT) are generally benign and slow growing, but in some cases, they can present with the invasion of dura, bone or surrounding structures in the absence of malignant features. In these cases, they are defined as

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Solène Castellnou, Alexandre Vasiljevic, Véronique Lapras, Véronique Raverot, Eudeline Alix, Françoise Borson-Chazot, Emmanuel Jouanneau, Gérald Raverot and Hélène Lasolle

Introduction Cushing’s disease is a rare disorder defined as chronic hypercortisolism due to a corticotropin-secreting pituitary tumor (corticotroph tumor) ( 1 ). Chronic cortisol excess is responsible for multisystem morbidity, contributing

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Jintao Hu, Qingbo Chen, Xiao Ding, Xin Zheng, Xuefeng Tang, Song Li and Hui Yang

Background Pituitary adenoma (PA) is the second most common brain tumor. Except for prolactinoma, pituitary tumors associated with acromegaly (growth hormone-secreting) and Cushing’s disease (adrenocorticotropic hormone-secreting) as well as

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Marco Marino, Valentina Cirello, Valentina Gnarini, Carla Colombo, Elisa Pignatti, Livio Casarini, Chiara Diazzi, Vincenzo Rochira, Katia Cioni, Bruno Madeo, Cesare Carani, Manuela Simoni and Laura Fugazzola

this association (7, 8) . Therefore, the involvement of the genomic variant pre-miR-146a rs2910164 in thyroid cancers remains unclear. Interestingly, on the same chromosome 5, ∼50 kb separate pre-miR-146a (OMIM*610566) from the pituitary tumor

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Emmanuelle Motte, Anya Rothenbuhler, Stephan Gaillard, Najiba Lahlou, Cécile Teinturier, Régis Coutant and Agnès Linglart

experienced multidisciplinary team, defined by the Pituitary Society as Pituitary Tumor Centers of Excellence (PTCOE) ( 32 ). Like in adults, the ideal treatment is based on excision of the ACTH-secreting corticotroph adenoma; however, several factors may

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Boni Xiang, Ran Tao, Xinhua Liu, Xiaoming Zhu, Min He, Zengyi Ma, Yehong Yang, Zhaoyun Zhang, Yiming Li, Zhenwei Yao, Yongfei Wang and Hongying Ye

transsphenoidal pituitary tumor resection (TSS) through a microscope or endoscope. Remission was defined as morning serum cortisol levels lower than 5.0 μg/dL within 7 days of selective tumor resection ( 10 ). The cortisone replacement began after remission, and

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Adrian F Daly, Liliya Rostomyan, Daniela Betea, Jean-François Bonneville, Chiara Villa, Natalia S Pellegata, Beatrice Waser, Jean-Claude Reubi, Catherine Waeber Stephan, Emanuel Christ and Albert Beckers

.5%) ( 5 ). The pituitary tumors in acromegaly are generally macroadenomas (>10 mm in diameter), and nearly half of patients have local tumor invasion at diagnosis. Many studies have examined the molecular genetic pathophysiology of acromegaly. The best

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Anna-Pauliina Iivonen, Johanna Känsäkoski, Atte Karppinen, Leena Kivipelto, Camilla Schalin-Jäntti, Auli Karhu and Taneli Raivio

demonstrated in a subset of exceptionally large, somatostatin analog (SMS)-resistant somatotropinomas ( 25 ). Wnt pathway inhibitors have been found to be downregulated in GH-secreting pituitary tumors ( 26 , 27 ), suggesting that Wnt signaling, possibly

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Giovanni Tulipano

anti-tumor effects in endocrine malignancies ( 16 ). The last section of this review explores the results of preclinical studies aimed at investigating the effects of AMPK activation and the effects of metformin on pituitary tumor cells published in the

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Paula Bruna Araujo, Leandro Kasuki, Carlos Henrique de Azeredo Lima, Liana Ogino, Aline H S Camacho, Leila Chimelli, Márta Korbonits and Monica R Gadelha

Universidade Federal do Rio de Janeiro (HUCFF-UFRJ) approved the study. Genetic counseling was provided for family members of AIPmut -positive cases, and clinical testing and follow-up were offered, whenever possible. Pituitary tumor samples Formalin