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Li Li, Qifa Song and Xi Yang

exhaustion of pancreatic β-cells ( 1 ). This deficiency in insulin function is the primary cause for developing a metabolically unhealthy status in patients with obesity who usually display impaired glucose tolerance (IGT) and even type 2 diabetic mellitus (T

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Alexis Sudlow, Carel W le Roux and Dimitri J Pournaras

with obesity who also suffer from gastro-oesophageal reflux. In these patients, RYGB may be a particularly pragmatic choice given its efficacy as a treatment for reflux in its own right. Following any bariatric procedures, there is the risk of

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Fahim Ebrahimi, Sandrine A Urwyler, Philipp Schuetz, Beat Mueller, Luca Bernasconi, Peter Neyer, Marc Y Donath and Mirjam Christ-Crain

on both systolic and diastolic blood pressure, by −3.1 mmHg and −2.7 mmHg, respectively. Heart rate was not affected ( 15 ). IL-1 antagonism has been shown to improve glycemia via improved beta-cell secretory function ( 12 ) in patients with obesity

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Sayaka Kawano, Yukiko Kawagoe, Kenji Kuwasako, Satoshi Shimamoto, Koji Igarashi, Mariko Tokashiki, Kazuo Kitamura and Johji Kato

been found to be higher in patients with obesity than in control subjects, suggesting the active production and secretion of AM from human adipose tissue (6, 9) . Consistent with this, Nambu et al . (10) reported that mice fed a high-fat diet showed

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Wenqi Yang, Ling Liu, Yuan Wei, Chunlu Fang, Fu Zhou, Jinbao Chen, Qinghua Han, Meifang Huang, Xuan Tan, Qiuyue Liu, Qiang Pan, Lu Zhang, Xiaojuan Lei and Liangming Li

patient with obesity and T2DM, and in the general population, low circulating adiponectin levels are associated with increased risk of T2DM ( 36 ). Administration of adiponectin to diabetic animals corrected glucose disturbance ( 37 ). In blood

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Frederique Van de Velde, Marlies Bekaert, Anja Geerts, Anne Hoorens, Arsène-Hélène Batens, Samyah Shadid, Margriet Ouwens, Yves Van Nieuwenhove and Bruno Lapauw

methods are NAFLD Activity Score (NAS) and Steatosis, Activity, and Fibrosis (SAF) score ( 3 ). Importantly, patients with obesity who develop NAFLD are also more prone to develop other metabolic consequences of obesity such as insulin resistance (IR

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Jie Shi, Zhen Yang, Yixin Niu, Weiwei Zhang, Ning Lin, Xiaoyong Li, Hongmei Zhang, Hongxia Gu, Jie Wen, Guang Ning, Li Qin and Qing Su

closely associated with increased risk factors for hypertension and diabetes ( 30 , 31 ). Clear evidence demonstrated that obese individuals with sarcopenia have a higher risk of hypertension than patients with obesity or sarcopenia alone ( 31 , 32

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Marloes Emous, Merel van den Broek, Ragnhild B Wijma, Loek J M de Heide, Gertjan van Dijk, Anke Laskewitz, Erik Totté, Bruce H R Wolffenbuttel and André P van Beek

Introduction The laparoscopic Roux-en-Y gastric bypass (RYGB) is often used to achieve sustained weight loss, resolve comorbidity and improve survival in patients with obesity ( 1 ). It is an effective procedure, but unfortunately, it can be

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Monika Karczewska-Kupczewska, Agnieszka Nikołajuk, Magdalena Stefanowicz, Natalia Matulewicz, Irina Kowalska and Marek Strączkowski

Fahlbusch P Herzfeld de Wiza D Van Nieuwenhove Y Calders P Praet M Hoorens A , et al . Reduced expression of chemerin in visceral adipose tissue associates with hepatic steatosis in patients with obesity . Obesity 2016 24 2544 – 2552

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Elisabet Einarsdottir, Minna Pekkinen, Kaarel Krjutškov, Shintaro Katayama, Juha Kere, Outi Mäkitie and Heli Viljakainen

activity in skeletal muscle and adipose tissue in patients with obesity and type 2 diabetes ( 23 , 24 , 25 ). In fact, mitochondrial dysfunction is suggested to precede the development of insulin resistance ( 26 , 27 ). In a recent metabolomics study