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Maria Luisa Garo Mathsly Research, Roma, Italy

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Désirée Deandreis Division of Nuclear Medicine, Department of Medical Sciences, AOU Città della Salute e della Scienza, University of Turin, Turin, Italy

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Alfredo Campennì Nuclear Medicine Unit, Department of Biomedical and Dental Sciences and Morpho-Functional Imaging, University of Messina, Messina, Italy

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Alexis Vrachimis Department of Nuclear Medicine, German Oncology Center, University Hospital of the European University, Limassol, Cyprus

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Petra Petranovic Ovcaricek Department of Oncology and Nuclear Medicine, University Hospital Center Sestre Milosrdnice, Zagreb, Croatia

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Luca Giovanella Clinic for Nuclear Medicine and Molecular Imaging, Imaging Institute of Southern Switzerland, Ente Ospedaliero Cantonale, Bellinzona, Switzerland
Clinic for Nuclear Medicine, University Hospital of Zürich, Zürich, Switzerland

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database (CRD42022327028). The components of the PICOT questions were: population, patients with papillary thyroid cancer; comparator prognostic factor, single-arm studies; outcomes, OS, DFS, cancer-specific survival, recurrence, CLNM, or LLNM; timing

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Abdul K Siraj Human Cancer Genomic Research, Research Centre, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia

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Rong Bu Human Cancer Genomic Research, Research Centre, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia

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Maham Arshad Human Cancer Genomic Research, Research Centre, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia

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Kaleem Iqbal Human Cancer Genomic Research, Research Centre, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia

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Sandeep Kumar Parvathareddy Human Cancer Genomic Research, Research Centre, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia

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Tariq Masoodi Human Cancer Genomic Research, Research Centre, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia

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Laila Omar Ghazwani Human Cancer Genomic Research, Research Centre, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia

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Saif S Al-Sobhi Department of Surgery, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia

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Fouad Al-Dayel Department of Pathology and Laboratory Medicine, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia

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Khawla S Al-Kuraya Human Cancer Genomic Research, Research Centre, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia

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cancer, among females in Saudi Arabia, with a significantly higher incidence rate when compared to other countries, such as the USA ( 2 , 3 ). Amongst the different subtypes, papillary thyroid cancer (PTC) is the most common and accounts for 80–90% of

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Yuting Shao Department of Endocrinology, Qilu Hospital of Shandong University, Jinan, Shandong, China

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Xiaole Hu Department of Operating Room, Qilu Hospital of Shandong University, Shandong, China

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Yuxi Wang Department of Breast and Thyroid Surgery, People’s Hospital of Mengyin County, Linyi, Shandong, China

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Yi Shao Department of Thyroid Surgery, General Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, China

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Luchuan Li Department of Thyroid Surgery, General Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, China

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Qingdong Zeng Department of Thyroid Surgery, General Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, China

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Hong Lai Department of Endocrinology, Qilu Hospital of Shandong University, Jinan, Shandong, China

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Lei Sheng Department of Thyroid Surgery, General Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, China

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associated with poor clinicopathologic characteristics in female patients with papillary thyroid cancer . Thyroid 2014 24 1618 – 1624 . ( https://doi.org/10.1089/thy.2014.0090 ) 16 Demircioglu ZG Aygun N Demircioglu MK Ozguven BY & Uludag M

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Weiwei Liang Department of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China

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Yilin Zhang Department of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China
Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China

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Yan Guo Department of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China

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Pengyuan Zhang Department of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China

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Jiewen Jin Department of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China

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Hongyu Guan Department of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China

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Yanbing Li Department of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China

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differentiated and anaplastic thyroid cancer), and medullary thyroid cancer ( 1 ). Papillary thyroid cancer (PTC) is the most common subtype of thyroid cancer, which approximately accounts for more than 80% of all thyroid cancers ( 2 , 3 ). The majority of PTCs

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Yuntao Song Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education/Beijing, Department of Head and Neck Surgery, Peking University Cancer Hospital and Institute, Beijing, China

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Jiaxin Wang Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education/Beijing, Department of Head and Neck Surgery, Peking University Cancer Hospital and Institute, Beijing, China

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Yanli Zhu Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education/Beijing, Department of Pathology, Peking University Cancer Hospital and Institute, Beijing, China

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Guohui Xu Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education/Beijing, Department of Head and Neck Surgery, Peking University Cancer Hospital and Institute, Beijing, China

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Tianxiao Wang Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education/Beijing, Department of Head and Neck Surgery, Peking University Cancer Hospital and Institute, Beijing, China

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Bin Zhang Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education/Beijing, Department of Head and Neck Surgery, Peking University Cancer Hospital and Institute, Beijing, China

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Introduction The incidence-based mortality rates of thyroid cancer continued to increase over the past few decades, with papillary thyroid cancer (PTC) being the most common histology ( 1 ). Recurrent or persistent metastasis of the neck lymph

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Mubashir Mulla Department of Endocrine Surgery, King College London, King's Health Partners, King's College Hospital, Denmark Hill, London, SE5 9RS, UK
Department of Endocrine Surgery, King College London, King's Health Partners, King's College Hospital, Denmark Hill, London, SE5 9RS, UK

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Klaus-Martin Schulte Department of Endocrine Surgery, King College London, King's Health Partners, King's College Hospital, Denmark Hill, London, SE5 9RS, UK
Department of Endocrine Surgery, King College London, King's Health Partners, King's College Hospital, Denmark Hill, London, SE5 9RS, UK
Department of Endocrine Surgery, King College London, King's Health Partners, King's College Hospital, Denmark Hill, London, SE5 9RS, UK

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Introduction Papillary thyroid cancer (PTC) is the most common thyroid cancer. Metastases from PTC most commonly involve the cervical lymph nodes (CLNs). The incidence of CLN metastases (CLNM) is reported between 30 and 80% (1, 2) . Some studies

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Pan Chen Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China

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Liqin Pan Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China

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Wensi Huang Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China

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Huijuan Feng Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China

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Wei Ouyang Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China

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Juqing Wu Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China

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Jing Wang Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China

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Yuying Deng Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China

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Jiaxin Luo Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China

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Yanying Chen Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China

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fourth most common malignant tumor among women ( 1 ). More than 95% of thyroid cancer cases involve differentiated thyroid cancer (DTC) and up to 90% belong to papillary thyroid cancer (PTC) ( 2 ). The BRAF V600E mutation is the most common genetic

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C Chiapponi Department of General, Visceral, Cancer and Transplant Surgery, University Hospital of Cologne, Cologne, Germany

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H Alakus Department of General, Visceral, Cancer and Transplant Surgery, University Hospital of Cologne, Cologne, Germany

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M Faust Polyclinic for Endocrinology, Diabetes and Preventive Medicine, University Hospital of Cologne, Cologne, Germany

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A M Schultheis Department of Pathology, University Hospital of Cologne, Cologne, Germany

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J Rosenbrock Department of Radiation Therapy, University Hospital of Cologne, Cologne, Germany

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M Schmidt Department of Nuclear Medicine, Faculty of Medicine, University Hospital of Cologne, Cologne, Germany

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, alongside with complete tumor resection, low morbidity, and satisfying cosmetic results ( 1 ). The use of prophylactic resection of clinically not involved central lymph nodes for papillary thyroid cancer (PTC), for example, is very controversial ( 2 , 3

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Ana P Estrada-Flórez Genome Center and Department of Biochemistry and Molecular Medicine, School of Medicine, University of California, Davis, California, USA
Grupo de Citogenética, Filogenia y Evolución de Poblaciones, Facultad de Ciencias y Facultad de Ciencias de la Salud, Universidad del Tolima, Ibagué, Tolima, Colombia
Facultad de Ciencias para la Salud, Universidad de Caldas, Manizales, Caldas, Colombia

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Mabel E Bohórquez Grupo de Citogenética, Filogenia y Evolución de Poblaciones, Facultad de Ciencias y Facultad de Ciencias de la Salud, Universidad del Tolima, Ibagué, Tolima, Colombia

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Alejandro Vélez Dinamica IPS, Medellín, Antioquia, Colombia
Hospital Pablo Tobón Uribe, Medellín, Antioquia, Colombia

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Carlos S Duque Hospital Pablo Tobón Uribe, Medellín, Antioquia, Colombia

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Jorge H Donado Hospital Pablo Tobón Uribe, Medellín, Antioquia, Colombia

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Gilbert Mateus Hospital Federico Lleras Acosta, Ibagué, Tolima, Colombia

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Cesar Panqueba-Tarazona Universidad Surcolombiana, Neiva, Huila, Colombia

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Guadalupe Polanco-Echeverry Genome Center and Department of Biochemistry and Molecular Medicine, School of Medicine, University of California, Davis, California, USA

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Ruta Sahasrabudhe Genome Center and Department of Biochemistry and Molecular Medicine, School of Medicine, University of California, Davis, California, USA

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Magdalena Echeverry Grupo de Citogenética, Filogenia y Evolución de Poblaciones, Facultad de Ciencias y Facultad de Ciencias de la Salud, Universidad del Tolima, Ibagué, Tolima, Colombia

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Luis G Carvajal-Carmona Genome Center and Department of Biochemistry and Molecular Medicine, School of Medicine, University of California, Davis, California, USA
Dinamica IPS, Medellín, Antioquia, Colombia
University of California Davis Comprehensive Cancer Center, Sacramento, California, USA
Fundación de Genética y Genómica, Medellín, Antioquia, Colombia

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Introduction In the United States and several other countries, the incidence of papillary thyroid cancer (PTC) has significantly increased in recent decades ( 1 ). PTC is now the second most commonly diagnosed malignancy among US Latinas ( 2

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Agnieszka Adamska Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Białystok, Białystok, Poland

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Paulina Tomczuk-Bobik Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Białystok, Białystok, Poland

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Anna Beata Popławska-Kita Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Białystok, Białystok, Poland

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Katarzyna Siewko Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Białystok, Białystok, Poland

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Angelika Buczyńska Clinical Research Centre, Medical University of Bialystok, Białystok, Poland

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Piotr Szumowski Department of Nuclear Medicine, Medical University of Białystok, Białystok, Poland

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Łukasz Żukowski Department of Nuclear Medicine, Medical University of Białystok, Białystok, Poland

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Janusz Myśliwiec Department of Nuclear Medicine, Medical University of Białystok, Białystok, Poland

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Monika Zbucka-Krętowska Department of Gynecological Endocrinology and Adolescent Gynecology, Medical University of Bialystok, Białystok, Poland

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Marcin Adamski Faculty of Computer Science, Bialystok University of Technology, Białystok, Poland

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Adam Jacek Krętowski Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Białystok, Białystok, Poland
Clinical Research Centre, Medical University of Bialystok, Białystok, Poland

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Introduction One of the most common types of endocrine cancer, especially in young women, is thyroid cancer ( 1 ). More than 90% of all thyroid cancers are differentiated thyroid cancers (DTC), including papillary thyroid cancer (PTC) and

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