Aida Javanbakht
Aida Javanbakht
Department of Diabetes, Endocrinology and Metabolism, Beckman Research Institute of City of Hope, Duarte, California, USA
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Massimo D’Apuzzo
Massimo D’Apuzzo
Department of Pathology, Beckman Research Institute of City of Hope, Duarte, California, USA
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Behnam Badie
Behnam Badie
Department of Neurosurgery, Beckman Research Institute of City of Hope, Duarte, California, USA
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Behrouz Salehian
Behrouz Salehian
Department of Diabetes, Endocrinology and Metabolism, Beckman Research Institute of City of Hope, Duarte, California, USA
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panhypopituitarism (3 cases) and DI (3 cases). Visual symptoms were also noted in two patients. In keeping with the natural history of these lesions, several patients did not have any pituitary-related clinical manifestations. Four patients underwent transsphenoidal
L M Mongioì
L M Mongioì
Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy
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R A Condorelli
R A Condorelli
Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy
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S La Vignera
S La Vignera
Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy
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A E Calogero
A E Calogero
Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy
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Objective
Adrenal insufficiency (AI) is a chronic condition associated with increased mortality and morbidity. The treatment of AI in the last years has been object of important changes due to the development of a dual-release preparation of hydrocortisone. It differs from previous therapeutic strategy as it contemplates a once-daily tablet that allows more closely mimicking the physiological circadian cortisol rhythm. The aim of the study was to evaluate the effects of dual-release hydrocortisone treatment on the glycometabolic profile and health-related quality of life of patients with AI.
Design and Methods
In this clinical open trial, we enrolled ten patients with primary AI (41 ± 2.67 years) and nine patients with AI secondary to hypopituitarism (53.2 ± 17.7 years). We evaluated the glycometabolic profile before and 3, 6, 9 and 12 months after dual-release hydrocortisone administration. We also evaluated health-related quality of life, estimated by the AddiQol questionnaire. The mean dose administered of dual-release hydrocortisone was 28.33 ± 6.68 mg/day.
Results
One female hypopituitary patient dropped out from the study. After 12 months of treatment, the mean dosage administered of dual-release hydrocortisone was significantly lower (P < 0.05) and all patients reported improved quality of life and well-being. The glycometabolic profile improved and the glycosylated hemoglobin decreased significantly in patients with primary AI (6.25 ± 0.2 vs 5.35 ± 0.17, P < 0.05). In contrast, hypopituitary patients had worse glycometabolic profile and a trend toward hypertriglyceridemia.
Conclusions
Dual-release hydrocortisone treatment improved the quality of life of patients with AI, and it allowed a decrease of cortisol dosage administered in the absence of side effects. The glycometabolic profile worsened in hypopituitary patients.
Ruth Percik
Ruth Percik
Institute of Endocrinology, Diabetes and Metabolism, Sheba Medical Centre, Ramat Gan, Israel
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Sherwin Criseno
Sherwin Criseno
Department of Endocrinology, University Hospital Birmingham, Birmingham, UK
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Safwaan Adam
Safwaan Adam
Department of Endocrinology, The Christie NHS Foundation Trust, Manchester, UK
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Kate Young
Kate Young
Royal Marsden Hospital, London, UK
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Daniel L Morganstein
Daniel L Morganstein
Department of Endocrinology, Chelsea and Westminster Hospital, London, UK
Royal Marsden Hospital, London, UK
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Royal Marsden Hospital, London, UK
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. Hypothalamic–pituitary–adrenal (HPA) axis Hypophysitis and hypopituitarism Pituitary abnormalities are reported in between 1.8 and 18.3% of patients treated with ipilimumab-based regimens ( 17 ), usually resulting in panhypopituitarism, associated with
J Van Schaik
J Van Schaik
Division of Pediatric Endocrinology, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
Division of Pediatric Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
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Division of Pediatric Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
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M Burghard
M Burghard
Division of Pediatric Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
Department of Exercise Physiology, Child Development & Exercise Center, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
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Department of Exercise Physiology, Child Development & Exercise Center, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
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M H Lequin
M H Lequin
Division of Pediatric Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
Department of Radiology, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
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Department of Radiology, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
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E A van Maren
E A van Maren
Division of Pediatric Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
Department of Radiology, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
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Department of Radiology, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
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A M van Dijk
A M van Dijk
Department of Dietetics, University Medical Center Utrecht, Utrecht, The Netherlands
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T Takken
T Takken
Division of Pediatric Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
Department of Exercise Physiology, Child Development & Exercise Center, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
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Department of Exercise Physiology, Child Development & Exercise Center, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
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L B Rehorst-Kleinlugtenbelt
L B Rehorst-Kleinlugtenbelt
Division of Pediatric Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
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B Bakker
B Bakker
Division of Pediatric Endocrinology, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
Division of Pediatric Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
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Division of Pediatric Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
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L Meijer
L Meijer
Division of Pediatric Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
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E W Hoving
E W Hoving
Division of Neurosurgery, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
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M Fiocco
M Fiocco
Division of Pediatric Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
Institute of Mathematics, Leiden University, Leiden, The Netherlands
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Institute of Mathematics, Leiden University, Leiden, The Netherlands
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A Y N Schouten-van Meeteren
A Y N Schouten-van Meeteren
Division of Pediatric Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
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W J E Tissing
W J E Tissing
Division of Pediatric Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
Division of Pediatric Oncology, University Medical Centre Groningen, Groningen, The Netherlands
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Division of Pediatric Oncology, University Medical Centre Groningen, Groningen, The Netherlands
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H M van Santen
H M van Santen
Division of Pediatric Endocrinology, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
Division of Pediatric Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
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Division of Pediatric Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
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pituitary dysfunction and/or diabetes insipidus (DI)), grade II (panhypopituitarism with DI), and grade III (panhypopituitarism with DI and impaired thirst regulation) ( 46 ). Neuroimaging On the brain MRI performed at time of diagnosis, the
I M A A van Roessel
I M A A van Roessel
Department of Pediatric Endocrinology, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
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J P de Graaf
J P de Graaf
Dutch Pituitary Foundation, Nijkerk, The Netherlands
Department of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands
Endo-ERN European Reference Network on Rare endocrine conditions
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Department of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands
Endo-ERN European Reference Network on Rare endocrine conditions
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N R Biermasz
N R Biermasz
Department of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands
Endo-ERN European Reference Network on Rare endocrine conditions
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Endo-ERN European Reference Network on Rare endocrine conditions
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E Charmandari
E Charmandari
Division of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, National and Kapodistrian University of Athens Medical School, Aghia Sophia Children's Hospital, Athens, Greece
Division of Endocrinology and Metabolism, Center for Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, Athens, Greece
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Division of Endocrinology and Metabolism, Center for Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, Athens, Greece
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H M van Santen
H M van Santen
Department of Pediatric Endocrinology, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
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). Unfortunately, there is no effective treatment for all aspects of HD, and HD may not be the same for every individual; some patients will experience obesity, sleep problems and panhypopituitarism while others may be more disturbed by hypothermia and DI with
Kunal Thakkar
Kunal Thakkar
Department of Endocrinology, Seth G S Medical College & KEM Hospital, Mumbai, India
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Swati Ramteke-Jadhav
Swati Ramteke-Jadhav
Department of Endocrinology, Seth G S Medical College & KEM Hospital, Mumbai, India
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Rajeev Kasaliwal
Rajeev Kasaliwal
Department of Endocrinology, Mahatma Gandhi Medical College & Hospital, Jaipur, India
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Saba Samad Memon
Saba Samad Memon
Department of Endocrinology, Seth G S Medical College & KEM Hospital, Mumbai, India
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Virendra Patil
Virendra Patil
Department of Endocrinology, Seth G S Medical College & KEM Hospital, Mumbai, India
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Puja Thadani
Puja Thadani
Department of Endocrinology, Seth G S Medical College & KEM Hospital, Mumbai, India
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Nilesh Lomte
Nilesh Lomte
Department of Endocrinology, Seth G S Medical College & KEM Hospital, Mumbai, India
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Shilpa Sankhe
Shilpa Sankhe
Department of Radiology, Seth G S Medical College & KEM Hospital, Mumbai, India
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Atul Goel
Atul Goel
Department of Neurosurgery, Seth G S Medical College & KEM Hospital, Mumbai, India
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Sridhar Epari
Sridhar Epari
Department of Pathology, Tata Memorial Centre, Mumbai, India
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Naina Goel
Naina Goel
Department of Neuropathology, Seth G S Medical College & KEM Hospital, Mumbai, India
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Anurag Lila
Anurag Lila
Department of Endocrinology, Seth G S Medical College & KEM Hospital, Mumbai, India
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Nalini S Shah
Nalini S Shah
Department of Endocrinology, Seth G S Medical College & KEM Hospital, Mumbai, India
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Tushar Bandgar
Tushar Bandgar
Department of Endocrinology, Seth G S Medical College & KEM Hospital, Mumbai, India
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.72/0.52 – <0.2 1.44 2.8/2.1 NA sterile abscess TSS DI 12 months, No residue/recurrence, panhypopituitarism on replacement 2 35/M Headache, fever, weight loss 0.94/1.02 – 4.35 7.9 2.1/1.78 2.31 tubercular abscess ATT
Alessandro Barbato
Alessandro Barbato
Auxo-endocrinology Unit, Meyer Children's Hospital IRCCS, Florence, Italy
Department of Health Sciences, University of Florence, Florence, Italy
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Department of Health Sciences, University of Florence, Florence, Italy
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Giulia Gori
Giulia Gori
Medical Genetics Unit, Meyer Children’s Hospital IRCCS, Florence, Italy
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Michele Sacchini
Michele Sacchini
Metabolic and Muscular Unit, Meyer Children's Hospital IRCCS, Florence, Italy
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Francesca Pochiero
Francesca Pochiero
Metabolic and Muscular Unit, Meyer Children's Hospital IRCCS, Florence, Italy
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Sara Bargiacchi
Sara Bargiacchi
Medical Genetics Unit, Meyer Children’s Hospital IRCCS, Florence, Italy
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Giovanna Traficante
Giovanna Traficante
Medical Genetics Unit, Meyer Children’s Hospital IRCCS, Florence, Italy
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Viviana Palazzo
Viviana Palazzo
Medical Genetics Unit, Meyer Children’s Hospital IRCCS, Florence, Italy
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Lucia Tiberi
Lucia Tiberi
Medical Genetics Unit, Meyer Children’s Hospital IRCCS, Florence, Italy
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Claudia Bianchini
Claudia Bianchini
Pediatric Neurology and Neurogenetics Unit and Laboratories, Meyer Children’s Hospital IRCCS, Florence, Italy
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Davide Mei
Davide Mei
Pediatric Neurology and Neurogenetics Unit and Laboratories, Meyer Children’s Hospital IRCCS, Florence, Italy
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Elena Parrini
Elena Parrini
Pediatric Neurology and Neurogenetics Unit and Laboratories, Meyer Children’s Hospital IRCCS, Florence, Italy
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Tiziana Pisano
Tiziana Pisano
Pediatric Neurology and Neurogenetics Unit and Laboratories, Meyer Children’s Hospital IRCCS, Florence, Italy
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Elena Procopio
Elena Procopio
Metabolic and Muscular Unit, Meyer Children's Hospital IRCCS, Florence, Italy
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Renzo Guerrini
Renzo Guerrini
Pediatric Neurology and Neurogenetics Unit and Laboratories, Meyer Children’s Hospital IRCCS, Florence, Italy
NEUROFARBA Department, University of Florence, Florence, Italy
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NEUROFARBA Department, University of Florence, Florence, Italy
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Angela Peron
Angela Peron
Medical Genetics Unit, Meyer Children’s Hospital IRCCS, Florence, Italy
Department of Clinical and Experimental Biomedical Sciences “Mario Serio”, University of Florence, Florence, Italy
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Department of Clinical and Experimental Biomedical Sciences “Mario Serio”, University of Florence, Florence, Italy
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Stefano Stagi
Stefano Stagi
Auxo-endocrinology Unit, Meyer Children's Hospital IRCCS, Florence, Italy
Department of Health Sciences, University of Florence, Florence, Italy
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Department of Health Sciences, University of Florence, Florence, Italy
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unrelated patient with progressive panhypopituitarism and DEE in whom we identified homozygous missense SCO1 mutations. To our knowledge, DEE and pituitary involvement have not yet been associated with MC4DN4. Subjects and methods We conducted a
G Giuffrida
G Giuffrida
Endocrine Unit of University Hospital ‘AOU Policlinico G. Martino’, Messina, Italy
PhD School of Clinical and Experimental Biomedical Sciences, University of Messina, Messina, Sicily, Italy
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PhD School of Clinical and Experimental Biomedical Sciences, University of Messina, Messina, Sicily, Italy
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F Ferraù
F Ferraù
Endocrine Unit of University Hospital ‘AOU Policlinico G. Martino’, Messina, Italy
Department of Human Pathology ‘G. Barresi’, University of Messina, Messina, Sicily, Italy
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Department of Human Pathology ‘G. Barresi’, University of Messina, Messina, Sicily, Italy
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R Laudicella
R Laudicella
Nuclear Medicine Unit of University Hospital ‘AOU Policlinico G. Martino’, Messina, Italy
Department of Biomorphology, University of Messina, Messina, Sicily, Italy
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Department of Biomorphology, University of Messina, Messina, Sicily, Italy
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O R Cotta
O R Cotta
Department of Human Pathology ‘G. Barresi’, University of Messina, Messina, Sicily, Italy
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E Messina
E Messina
Endocrine Unit of University Hospital ‘AOU Policlinico G. Martino’, Messina, Italy
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F Granata
F Granata
Department of Biomorphology, University of Messina, Messina, Sicily, Italy
Neuroradiology Unit of University Hospital ‘AOU Policlinico G. Martino’, Messina, Italy
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Neuroradiology Unit of University Hospital ‘AOU Policlinico G. Martino’, Messina, Italy
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F F Angileri
F F Angileri
Department of Biomorphology, University of Messina, Messina, Sicily, Italy
Neurosurgery Unit of University Hospital ‘AOU Policlinico G. Martino’, Messina, Italy
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Neurosurgery Unit of University Hospital ‘AOU Policlinico G. Martino’, Messina, Italy
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A Vento
A Vento
Nuclear Medicine Unit of University Hospital ‘AOU Policlinico G. Martino’, Messina, Italy
Department of Biomorphology, University of Messina, Messina, Sicily, Italy
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Department of Biomorphology, University of Messina, Messina, Sicily, Italy
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A Alibrandi
A Alibrandi
Department of Economics, University of Messina, Messina, Sicily, Italy
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S Baldari
S Baldari
Nuclear Medicine Unit of University Hospital ‘AOU Policlinico G. Martino’, Messina, Italy
Department of Biomorphology, University of Messina, Messina, Sicily, Italy
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Department of Biomorphology, University of Messina, Messina, Sicily, Italy
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S Cannavò
S Cannavò
Endocrine Unit of University Hospital ‘AOU Policlinico G. Martino’, Messina, Italy
PhD School of Clinical and Experimental Biomedical Sciences, University of Messina, Messina, Sicily, Italy
Department of Human Pathology ‘G. Barresi’, University of Messina, Messina, Sicily, Italy
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PhD School of Clinical and Experimental Biomedical Sciences, University of Messina, Messina, Sicily, Italy
Department of Human Pathology ‘G. Barresi’, University of Messina, Messina, Sicily, Italy
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. Panhypopituitarism had occurred after radiosurgery. In 2015, he began PRRT but a dramatic increase in tumor size (from 20.2 to 83.6 mL), impairment of visual acuity and worsening of clinical conditions occurred after the second cycle of treatment. For this reason
Nathalie Ly
Nathalie Ly
Department of Endocrinology and Reproductive Medicine, Reference Center for Rare Endocrine Diseases of Growth and Development, Reference Center for Gynecological Rare Diseases, Hôpitaux Universitaires Pitié Salpêtrière-Charles Foix, Paris, France
EndoERN, APHP Consortium Pitie Salpetriere Hospital, Necker Hospital, Paris, France
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EndoERN, APHP Consortium Pitie Salpetriere Hospital, Necker Hospital, Paris, France
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Sophie Dubreuil
Sophie Dubreuil
Department of Endocrinology and Reproductive Medicine, Reference Center for Rare Endocrine Diseases of Growth and Development, Reference Center for Gynecological Rare Diseases, Hôpitaux Universitaires Pitié Salpêtrière-Charles Foix, Paris, France
EndoERN, APHP Consortium Pitie Salpetriere Hospital, Necker Hospital, Paris, France
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EndoERN, APHP Consortium Pitie Salpetriere Hospital, Necker Hospital, Paris, France
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Philippe Touraine
Philippe Touraine
Department of Endocrinology and Reproductive Medicine, Reference Center for Rare Endocrine Diseases of Growth and Development, Reference Center for Gynecological Rare Diseases, Hôpitaux Universitaires Pitié Salpêtrière-Charles Foix, Paris, France
EndoERN, APHP Consortium Pitie Salpetriere Hospital, Necker Hospital, Paris, France
Sorbonne University, Paris, France
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EndoERN, APHP Consortium Pitie Salpetriere Hospital, Necker Hospital, Paris, France
Sorbonne University, Paris, France
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growth hormone and gonadotropins in a woman with panhypopituitarism: a new treatment protocol . Fertility and Sterility 2000 74 1248 – 1250 . ( https://doi.org/10.1016/s0015-0282(0001619-8 ) 19 Müller J Starup J Christiansen JS Jørgensen JO
Lingjuan Li
Lingjuan Li
Department of Nursing, Huashan Hospital, Shanghai Medical School, Fudan University, Shanghai, China
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Jing Qin
Jing Qin
Department of Nursing, Huashan Hospital, Shanghai Medical School, Fudan University, Shanghai, China
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Lin Ren
Lin Ren
Department of Nursing, Huashan Hospital, Shanghai Medical School, Fudan University, Shanghai, China
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Shiyuan Xiang
Shiyuan Xiang
Department of Nursing, Huashan Hospital, Shanghai Medical School, Fudan University, Shanghai, China
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Xiaoyun Cao
Xiaoyun Cao
Department of Neurosurgery, Huashan Hospital, Shanghai Medical School, Fudan University, Shanghai, China
National Center for Neurological Disorders, Shanghai, China
Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
Neurosurgical Institute of Fudan University, Shanghai, China
Shanghai Key Laboratory of Medical Brain Function and Restoration and Neural Regeneration, Fudan University, Shanghai, China
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National Center for Neurological Disorders, Shanghai, China
Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
Neurosurgical Institute of Fudan University, Shanghai, China
Shanghai Key Laboratory of Medical Brain Function and Restoration and Neural Regeneration, Fudan University, Shanghai, China
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Xianglan Zheng
Xianglan Zheng
Department of Nursing, Huashan Hospital, Shanghai Medical School, Fudan University, Shanghai, China
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Zhiwen Yin
Zhiwen Yin
Department of Nursing, Huashan Hospital, Shanghai Medical School, Fudan University, Shanghai, China
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Nidan Qiao
Nidan Qiao
Department of Neurosurgery, Huashan Hospital, Shanghai Medical School, Fudan University, Shanghai, China
National Center for Neurological Disorders, Shanghai, China
Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
Neurosurgical Institute of Fudan University, Shanghai, China
Shanghai Key Laboratory of Medical Brain Function and Restoration and Neural Regeneration, Fudan University, Shanghai, China
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National Center for Neurological Disorders, Shanghai, China
Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
Neurosurgical Institute of Fudan University, Shanghai, China
Shanghai Key Laboratory of Medical Brain Function and Restoration and Neural Regeneration, Fudan University, Shanghai, China
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a patient with panhypopituitarism after short-term discontinuation of desmopressin . Israel Medical Association Journal 2020 22 330 – 332 . 6 Qiao N . A systematic review on machine learning in sellar region diseases: quality and reporting
