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Wentao Zhou
Wentao Zhou
The Research Institution of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China
Department of Pancreatic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China
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Department of Pancreatic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China
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Tiantao Kuang
Tiantao Kuang
The Research Institution of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China
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Xu Han
Xu Han
Department of Pancreatic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China
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Wenqi Chen
Wenqi Chen
Department of Pancreatic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China
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Xuefeng Xu
Xuefeng Xu
The Research Institution of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China
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Wenhui Lou
Wenhui Lou
Department of Pancreatic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China
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Dansong Wang
Dansong Wang
The Research Institution of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China
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Introduction Pancreatic neuroendocrine neoplasm (pNEN) is a rare malignancy arising from pancreatic islet cells and accounts for 1–2% of all pancreatic tumors ( 1 ). However, with the popularization of abdominal imaging and the promotion of
Linfei Yang
Linfei Yang
Center for Medical Experiments, The Third Xiangya Hospital, Central South University, Changsha, China
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Xiao Yu
Xiao Yu
Department of General Surgery, The Third Xiangya Hospital, Central South University, Changsha, China
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Yongchao Yang
Yongchao Yang
Department of Burns and Plastic Surgery, The Third Xiangya Hospital, Central South University, Changsha, China
European Pancreas Center, Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany
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European Pancreas Center, Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany
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Introduction The incidence of pancreatic neuroendocrine neoplasm (pNEN), the most aggressive neuroendocrine malignancy among gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs), has increased significantly over the past few decades
Simon Schimmack
Simon Schimmack
European Pancreas Center, Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany
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Yongchao Yang
Yongchao Yang
European Pancreas Center, Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany
Department of General Surgery, Xiangya Hospital, Central South University, Changsha, China
Department of Burns and Plastic Surgery, The Third Xiangya Hospital, Central South University, Changsha, China
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Department of General Surgery, Xiangya Hospital, Central South University, Changsha, China
Department of Burns and Plastic Surgery, The Third Xiangya Hospital, Central South University, Changsha, China
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Klaus Felix
Klaus Felix
European Pancreas Center, Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany
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Markus Herbst
Markus Herbst
European Pancreas Center, Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany
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Yixiong Li
Yixiong Li
Department of General Surgery, Xiangya Hospital, Central South University, Changsha, China
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Miriam Schenk
Miriam Schenk
European Pancreas Center, Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany
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Frank Bergmann
Frank Bergmann
Institute of Pathology, Heidelberg University, Heidelberg, Germany
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Thilo Hackert
Thilo Hackert
European Pancreas Center, Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany
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Oliver Strobel
Oliver Strobel
European Pancreas Center, Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany
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Introduction Pancreatic neuroendocrine neoplasm (pNEN), the most aggressive neuroendocrine malignancy, has an increasing incidence, with 3.2 cases per 1,000,000 inhabitants currently being diagnosed annually in the United States ( 1 , 2 , 3
Xu Han
Xu Han
Department of Pancreatic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China
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Xuefeng Xu
Xuefeng Xu
Department of Pancreatic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China
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Hongyun Ma
Hongyun Ma
Department of Pancreatic Surgery, Changhai Hospital, Second Military Medical University, Shanghai, China
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Yuan Ji
Yuan Ji
Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai, China
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Dansong Wang
Dansong Wang
Department of Pancreatic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China
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Tiantao Kuang
Tiantao Kuang
Department of Pancreatic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China
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Wenchuan Wu
Wenchuan Wu
Department of Pancreatic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China
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Bin Song
Bin Song
Department of Pancreatic Surgery, Changhai Hospital, Second Military Medical University, Shanghai, China
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Gang Li
Gang Li
Department of Pancreatic Surgery, Changhai Hospital, Second Military Medical University, Shanghai, China
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Gang Jin
Gang Jin
Department of Pancreatic Surgery, Changhai Hospital, Second Military Medical University, Shanghai, China
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Wenhui Lou
Wenhui Lou
Department of Pancreatic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China
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Introduction Pancreatic neuroendocrine neoplasms (pNENs) are rare and heterogeneous neoplasms of the pancreas, which make up 1–5% of all pancreatic neoplasms ( 1 , 2 ). The incidence and prevalence of pNENs have been increasing significantly
Qi Zhang
Qi Zhang
Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China
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Hongshan Wang
Hongshan Wang
Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China
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Yanhong Xie
Yanhong Xie
Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai, China
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Suming Huang
Suming Huang
Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai, China
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Ke Chen
Ke Chen
Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai, China
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Botian Ye
Botian Ye
Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China
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Yupeng Yang
Yupeng Yang
Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China
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Jie Sun
Jie Sun
Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China
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Hongyong He
Hongyong He
Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China
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Fenglin Liu
Fenglin Liu
Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China
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Zhenbin Shen
Zhenbin Shen
Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China
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Weidong Chen
Weidong Chen
Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China
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Kuntang Shen
Kuntang Shen
Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China
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Yuan Ji
Yuan Ji
Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai, China
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Yihong Sun
Yihong Sun
Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China
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Consensus on the Pathological Diagnosis of Gastrointestinal and Pancreatic Neuroendocrine Neoplasms Experts Group. Chinese consensus on the pathological diagnosis of G and pancreatic neuroendocrine neoplasms experts G . Chinese Journal of Pathology 2021
Kazhan Mollazadegan
Kazhan Mollazadegan
Department of Medical Sciences, Uppsala University, Uppsala, Sweden
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Britt Skogseid
Britt Skogseid
Department of Medical Sciences, Uppsala University, Uppsala, Sweden
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Johan Botling
Johan Botling
Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden
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Tobias Åkerström
Tobias Åkerström
Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
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Barbro Eriksson
Barbro Eriksson
Department of Medical Sciences, Uppsala University, Uppsala, Sweden
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Staffan Welin
Staffan Welin
Department of Medical Sciences, Uppsala University, Uppsala, Sweden
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Anders Sundin
Anders Sundin
Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
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Joakim Crona
Joakim Crona
Department of Medical Sciences, Uppsala University, Uppsala, Sweden
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Introduction Pancreatic neuroendocrine neoplasms (panNENs) constitute a heterogeneous group of different diseases, in terms of biology as well as in patient characteristics and outcomes. The panNENs displaying the highest proliferation rate
Chao-bin He
Chao-bin He
Department of Hepatobiliary and Pancreatic Surgery, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, People’s Republic of China
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Yu Zhang
Yu Zhang
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, Guangdong, People’s Republic of China
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Zhi-yuan Cai
Zhi-yuan Cai
Department of Hepatobiliary and Pancreatic Surgery, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, People’s Republic of China
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Xiao-jun Lin
Xiao-jun Lin
Department of Hepatobiliary and Pancreatic Surgery, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, People’s Republic of China
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patterns in the detection and outcomes of pancreatic neuroendocrine neoplasms: the Massachusetts General Hospital experience from 1977 to 2005 . Archives of Surgery 2007 142 347 – 354 . ( https://doi.org/10.1001/archsurg.142.4.347 ) 10.1001/archsurg
Hanbaro Kim
Hanbaro Kim
Department of Surgery, Hallym University College of Medicine, Chuncheon, Republic of Korea
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Ki Byung Song
Ki Byung Song
Division of Hepatobilliary and Pancreatic Surgery, Department of Surgery, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Republic of Korea
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Dae Wook Hwang
Dae Wook Hwang
Division of Hepatobilliary and Pancreatic Surgery, Department of Surgery, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Republic of Korea
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Jae Hoon Lee
Jae Hoon Lee
Division of Hepatobilliary and Pancreatic Surgery, Department of Surgery, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Republic of Korea
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Shadi Alshammary
Shadi Alshammary
Department of Surgery, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia
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Song Cheol Kim
Song Cheol Kim
Division of Hepatobilliary and Pancreatic Surgery, Department of Surgery, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Republic of Korea
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.1001/archsurg.138.4.427 ) 11 Vagefi PA Razo O Deshpande V McGrath DJ Lauwers GY Thayer SP Warshaw AL Fernandez-Del Castillo C . Evolving patterns in the detection and outcomes of pancreatic neuroendocrine neoplasms: the Massachusetts General
Logan Mills
Logan Mills
Institute of Liver Studies, King’s College Hospital, London, UK
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Panagiotis Drymousis
Panagiotis Drymousis
Department of Surgery and Cancer, Imperial College, London, UK
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Yogesh Vashist
Yogesh Vashist
Department of General, Visceral and Thoracic Surgery, University Medical Center, Hamburg-Eppendorf, Hamburg, Germany
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Christoph Burdelski
Christoph Burdelski
Department of General, Visceral and Thoracic Surgery, University Medical Center, Hamburg-Eppendorf, Hamburg, Germany
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Andreas Prachalias
Andreas Prachalias
Department of Surgery, King’s College Hospital, London, UK
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Parthi Srinivasan
Parthi Srinivasan
Department of Surgery, King’s College Hospital, London, UK
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Krishna Menon
Krishna Menon
Department of Surgery, King’s College Hospital, London, UK
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Corina Cotoi
Corina Cotoi
Department of Histopathology, King’s College Hospital, London, UK
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Saboor Khan
Saboor Khan
Department of Surgery, University Hospitals Coventry and Warwickshire, Coventry, UK
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Judith Cave
Judith Cave
Department of Oncology, University Hospital, Southampton, UK
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Thomas Armstrong
Thomas Armstrong
Department of Surgery, University Hospital, Southampton, UK
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Martin O Weickert
Martin O Weickert
Department of Endocrinology, University Hospitals Coventry and Warwickshire, Coventry, UK
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Jakob Izbicki
Jakob Izbicki
Department of General, Visceral and Thoracic Surgery, University Medical Center, Hamburg-Eppendorf, Hamburg, Germany
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Joerg Schrader
Joerg Schrader
Departments of Gastroenterology and Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
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Andreja Frilling
Andreja Frilling
Department of Surgery and Cancer, Imperial College, London, UK
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John K Ramage
John K Ramage
Institute of Liver Studies, King’s College Hospital, London, UK
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Raj Srirajaskanthan
Raj Srirajaskanthan
Institute of Liver Studies, King’s College Hospital, London, UK
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-functional tumours observed for a period of three years. The second study ASPEN (a prospective evaluation of the management of sporadic asymptomatic non-functioning pancreatic neuroendocrine neoplasms ≤2 cm) is a prospective observational study assessing time to
Giulia Bresciani
Giulia Bresciani
Section of Endocrinology and Internal Medicine, Department of Medical Sciences, University of Ferrara, Ferrara, Italy
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Angeliki Ditsiou
Angeliki Ditsiou
Department of Biochemistry and Biomedicine, School of Life Sciences, University of Sussex, Brighton, UK
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Chiara Cilibrasi
Chiara Cilibrasi
Department of Biochemistry and Biomedicine, School of Life Sciences, University of Sussex, Brighton, UK
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Viviana Vella
Viviana Vella
Department of Biochemistry and Biomedicine, School of Life Sciences, University of Sussex, Brighton, UK
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Federico Rea
Federico Rea
Department of Cardiac, Thoracic and Vascular Sciences, University of Padua, Padua, Italy
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Marco Schiavon
Marco Schiavon
Department of Cardiac, Thoracic and Vascular Sciences, University of Padua, Padua, Italy
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Narciso Giorgio Cavallesco
Narciso Giorgio Cavallesco
Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy
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Georgios Giamas
Georgios Giamas
Department of Biochemistry and Biomedicine, School of Life Sciences, University of Sussex, Brighton, UK
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Maria Chiara Zatelli
Maria Chiara Zatelli
Section of Endocrinology and Internal Medicine, Department of Medical Sciences, University of Ferrara, Ferrara, Italy
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Teresa Gagliano
Teresa Gagliano
Department of Biochemistry and Biomedicine, School of Life Sciences, University of Sussex, Brighton, UK
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multi-tyrosine kinase growth factor receptor (RTKs) inhibitor indicated for the treatment of several NENs, such as gastrointestinal stromal tumours, advanced renal cell carcinoma and pancreatic neuroendocrine neoplasms ( 23 ). Its efficacy has been well
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