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Li Li, Qifa Song and Xi Yang

obesity, and a large proportion of patients with obesity show reduced pancreatic β-cell function despite low insulin resistance, which is causative to glucose dysmetabolism. In the future, the patients with distinct insulin resistance and insulin release

Open access

Chenghao Piao, Xiaojie Wang, Shiqiao Peng, Xinyu Guo, Hui Zhao, Li He, Yan Zeng, Fan Zhang, Kewen Zhu and Yiwei Wang

recombinant mouse IL-34 (rmIL-34) on apoptosis and pancreatic β cell function. Materials and methods Study groups A cross-section study was performed at the Second Affiliated Hospital of Shenyang Medical University. A total of 120 women were

Open access

Tingting Shu, Zhigang Lv, Yuchun Xie, Junming Tang and Xuhua Mao

on iron regulation, hepcidin is involved in glucotoxicity-mediated impairment of pancreatic β-cell function by inhibiting insulin synthesis ( 14 ). Under hyperglycemic conditions, the expression of hepcidin was inhibited and the iron metabolism

Open access

Thozhukat Sathyapalan, Anne-Marie Coady, Eric S Kilpatrick and Stephen L Atkin

Background

There is an increased risk of developing T2DM in women with polycystic ovary syndrome (PCOS), and there is evidence that statins improve metabolic parameters in these patients. However, there are some data to show that statins increase the risk of incipient diabetes.

Materials and methods

We have previously shown that 12 weeks of atorvastatin improves insulin resistance when measured using HOMA-IR. This post hoc analysis was designed to look at the effect of atorvastatin on pancreatic β cell function using HOMA-β in the same study. In this randomised, double-blind placebo controlled study, 40 medication-naïve patients with PCOS were randomised to either atorvastatin 20 mg daily or placebo for 3 months. A 3-month extension study for both groups of patients was undertaken with metformin 1500 mg daily after completing initial 3 months of atorvastatin or placebo.

Results

There was a significant reduction in HOMA-β (240 ± 3.2 vs 177 ± 2.3; P value <0.01) after 12 weeks of atorvastatin treatment, which was maintained by metformin in the subsequent 12 weeks. There were no changes in HOMA-β after the placebo or after subsequent metformin treatment.

There was no linear correlation between reduction in HOMA-β with improvement of free androgen index (FAI) (r 2 = 0.02; P = 0.72), testosterone (r 2 = 0.13; P = 0.49), SHBG (r 2 = 0.22; P = 0.48), hsCRP (r 2 = 0.19; P = 0.64), triglycerides (r 2 = 0.09; P = 0.12), total cholesterol (r 2 = 0.11; P = 0.32) or LDL-C (r 2 = 0.19; P = 0.38).

Conclusion

Treatment with atorvastatin for 12 weeks in women with PCOS significantly reduced HOMA-β. This could be potentially due to fall in β-cell requirement with improvement of insulin resistance rather than a reduction of β-cell function.

Open access

B Fabre, G Maccallini, A Oneto, D Gonzalez, V Hirschler, C Aranda and G Berg

origin tissue (8) is a basic parameter to evaluate pancreatic β-cell function and clinical situations that need of additional evidence to establish a diagnosis and an appropriate therapy. The aim of this study is to validate a salivary insulin method

Open access

Julia Modesto Vicente, Junia Carolina Santos-Silva, Caio Jordão Teixeira, Dailson Nogueira de Souza, Jean Franciesco Vettorazzi, Fabiola Sales Furtuoso, Isabel Gouveia Adabo, Fabio Takeo Sato, Marco Aurélio Ramirez Vinolo, Everardo Magalhães Carneiro, Silvana Bordin and Gabriel Forato Anhê

). Additional prospective data revealed that exclusive breastfeeding for at least 6 months presented increased insulin sensitivity as assessed by HOMA-IR index 3 years after delivery rather than increased pancreatic β-cell function as indicated by in vivo

Open access

Janaína Felix Braga, Daniela Ravizzoni Dartora, Natalia Alenina, Michael Bader and Robson Augusto Souza Santos

improves pancreatic β-cell function in vitro and in vivo . Endocrinology 2016 157 4677 – 4690 . ( doi:10.1210/en.2016-1247 ) 18 Dominici FP Burghi V Muñoz MC Giani JF. Modulation of the action of insulin by angiotensin-(1-7) . Clinical Science

Open access

Xuhua Mao, Hucheng Chen, Junmin Tang, Liangliang Wang and Tingting Shu

in addition to its role in iron regulation, hepcidin is involved in the mechanism by which gluco-toxicity impairs pancreatic β-cell function by inhibiting insulin synthesis. Furthermore, in addition to the inhibitory effects on insulin expression and

Open access

Maria Lola Evia-Viscarra, Edel Rafael Rodea-Montero, Evelia Apolinar-Jiménez and Silvia Quintana-Vargas

elucidate the risk factors and the time needed for their condition to lead to the deterioration of pancreatic β-cell function. Some authors consider MS to be a poor predictor of T2DM (37) and even suggest that haemaglobin A1c may be a more sensitive

Open access

Ali Abbasi

Medicine 2011 8 e1001112 . ( doi:10.1371/journal.pmed.1001112 ). 38 Song Y Yeung E Liu A Vanderweele TJ Chen L Lu C Liu C Schisterman EF Ning Y Zhang C . Pancreatic β-cell function and type 2 diabetes risk: quantify the causal