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Jie Shi, Zhen Yang, Yixin Niu, Weiwei Zhang, Ning Lin, Xiaoyong Li, Hongmei Zhang, Hongxia Gu, Jie Wen, Guang Ning, Li Qin and Qing Su

an automated electronic device (OMRON Model1 Plus; Omron Company, Kyoto, Japan) after the subjects sat down and rested quietly for >5 min. BP measurements were taken three times and the mean was recorded as the BP result. Overweight was defined as 24

Open access

Volha V Zhukouskaya, Anya Rothenbuhler, Annamaria Colao, Carolina Di Somma, Peter Kamenický, Séverine Trabado, Dominique Prié, Christelle Audrain, Anna Barosi, Christèle Kyheng, Anne-Sophie Lambert and Agnès Linglart

level and BMI. On the other hand, phosphorus supplementation for 3 months significantly decreased body weight, BMI, waist circumference; restored diet-induced thermogenesis; and increased post-prandial satiety in obese/overweight subjects ( 10 , 11

Open access

Charlotte Janus, Dorte Vistisen, Hanan Amadid, Daniel R Witte, Torsten Lauritzen, Søren Brage, Anne-Louise Bjerregaard, Torben Hansen, Jens J Holst, Marit E Jørgensen, Oluf Pedersen, Kristine Færch and Signe S Torekov

responsible for up to 70% of the postprandial insulin response in healthy individuals whilst being severely impaired in patients with prediabetes and T2D ( 5 , 6 ). Furthermore, GLP-1 responses are lower in individuals with overweight and obesity

Open access

Mirjam M Oosterwerff, Rosa Meijnen, Natasja M Van Schoor, Dirk L Knol, Mark H H Kramer, Mireille N M Van Poppel, Paul Lips and E Marelise W Eekhoff

Introduction Physical inactivity has been identified as the fourth leading risk factor for global mortality, while overweight and obesity are in the fifth place (1) . Both factors are more prevalent among non-western immigrants in The Netherlands

Open access

Mojca Jensterle, Nika Aleksandra Kravos, Simona Ferjan, Katja Goricar, Vita Dolzan and Andrej Janez

in overweight-obese patients with PCOS and normal baseline glycemic homeostasis on body mass (BM), menstrual frequencies (MF), metabolic and hormonal outcomes. This allows us to summarize our perspective in future research that can help to identify

Open access

Zeeshan Javed, Maria Papageorgiou, Leigh A Madden, Alan S Rigby, Eric S Kilpatrick, Stephen L Atkin and Thozhukat Sathyapalan

Context: Endothelial microparticles (EMPs) are novel, surrogate biomarkers of endothelial function and have been shown to be elevated in women with polycystic ovary syndrome (PCOS). It remains poorly understood how pharmacological options for managing PCOS affect EMP levels.

Objective: To characterise and compare the effects of empagliflozin vs. metformin on the circulating levels of EMPs in overweight/ obese women with PCOS.

Methods: This was a randomised, comparative, 12-week single-centre trial conducted at the Academic Diabetes, Endocrinology and Metabolism Research Centre, Hull, UK. This analysis includes data from thirty-nine overweight/obese women with PCOS who completed the study and were randomised to empagliflozin (15 mg/day) (n = 19) or metformin (1500 mg/day) (n = 20). Blood samples were collected at baseline and 12 weeks after treatment and analysed for specific surface proteins expressed by circulating EMPs using flow cytometry.

Results: In the empagliflozin group, ICAM-1 (p=0.006), E-selectin (p=0.016) and VCAM-1 (p=0.001) EMPs increased significantly following 12 weeks of treatment, but no changes were seen in PECAM-1 (p=0.93) or endoglin (p=0.13) EMPs. In the metformin group, VCAM-1 EMPs (p<0.001) increased significantly after 12 weeks of treatment, whereas all other EMPs remained unchanged. When data were expressed as the percentage change from baseline in each group, no significant differences were seen between groups for any biomarker (p-values from 0.22 to 0.80).

Conclusions: Short-term administration of empagliflozin and metformin in overweight/obese women with PCOS appear to increase EMPs expressed by endothelial cells during their activation.

Open access

Lars Peter Sørensen, Tina Parkner, Esben Søndergaard, Bo Martin Bibby, Holger Jon Møller and Søren Nielsen

demonstrated that expansion of visceral adipose tissue (VAT) rather than subcutaneous adipose tissue (SAT) depots is critical for the development of obesity-associated insulin resistance, and that, at least in overweight/obese subjects, expansion of SAT depots

Open access

S U Jayasinghe, S J Torres, C A Nowson, A J Tilbrook and A I Turner

baseline resting period and low frequency of sampling. Furthermore, very little research has considered the SAM system and the HPA axis together. The aims of this study were to determine whether lean and overweight/obese men differ in their cortisol and

Open access

Jing Wang, Leishen Wang, Huikun Liu, Shuang Zhang, Junhong Leng, Weiqin Li, Tao Zhang, Nan Li, Wei Li, Andrea A Baccarelli, Lifang Hou and Gang Hu

, two recent studies from the Hyperglycemia and Adverse Pregnancy Outcome study (HAPO) ( 10 ) and Kaiser Permanente Northwest and Hawaii ( 11 ) presented that maternal hyperglycemia during pregnancy increased the offspring’s risk of overweight and

Open access

N K Stepto, D Hiam, M Gibson-Helm, S Cassar, C L Harrison, S K Hutchison, A E Joham, B J Canny, A Moreno-Asso, B J Strauss, N Hatzirodos, R J Rodgers and H J Teede

(LP), (ii) lean without (control; LC), (iii) overweight to obese with PCOS (OWP) and (iv) overweight to obese without PCOS (control; OWC). Confirmation of PCOS diagnosis was undertaken by expert endocrinologists (SKH, AEJ and HJT) based on Rotterdam