Ya-Fen Hu
Ya-Fen Hu
Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, Beijing, China
Department of Endocrinology, The People’s Hospital of Daxing District, Beijing, China
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Department of Endocrinology, The People’s Hospital of Daxing District, Beijing, China
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Lin Hua
Lin Hua
Department of Mathematics, School of Biomedical Engineering, Capital Medical University, Beijing, China
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Xiu Tuo
Xiu Tuo
Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, Beijing, China
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Ting-Ting Shi
Ting-Ting Shi
Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, Beijing, China
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Yi-Lin Yang
Yi-Lin Yang
Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, Beijing, China
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Yun-Fu Liu
Yun-Fu Liu
Department of Radiology, Beijing Tongren Hospital, Capital Medical University, Beijing, China
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Zhong-Yu Yan
Zhong-Yu Yan
Department of Radiology, Beijing Tongren Hospital, Capital Medical University, Beijing, China
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Zhong Xin
Zhong Xin
Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, Beijing, China
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inflammation of the orbital tissues, which is known as GO ( 1 ). It occurs in patients with hyperthyroidism, hypothyroidism, or normal thyroid function. However, the pathogenesis underlying the disease has not yet been clarified. Several factors, including
B Shahida
B Shahida
Department of Clinical Sciences, Genomics, Diabetes and Endocrinology, Lund University, Malmö, Sweden
Department of Diabetes and Endocrinology, Skåne University Hospital, Malmö, Sweden
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Department of Diabetes and Endocrinology, Skåne University Hospital, Malmö, Sweden
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P Sahlstrand Johnson
P Sahlstrand Johnson
Department of Oto-Rhino-Laryngology, Skåne University Hospital, Malmö, Sweden
Department of Clinical Sciences, Lund University, Malmö, Sweden
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Department of Clinical Sciences, Lund University, Malmö, Sweden
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R Jain
R Jain
Department of Clinical Sciences, Genomics, Diabetes and Endocrinology, Lund University, Malmö, Sweden
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H Brorson
H Brorson
Department of Clinical Sciences, Lund University, Malmö, Sweden
Department of Plastic Surgery, Skåne University Hospital, Malmö, Sweden
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Department of Plastic Surgery, Skåne University Hospital, Malmö, Sweden
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P Åsman
P Åsman
Department of Clinical Sciences Malmö, Ophthalmology, Lund University, Malmö, Sweden
Department of Ophthalmology, Skåne University Hospital, Malmö, Sweden
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Department of Ophthalmology, Skåne University Hospital, Malmö, Sweden
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M Lantz
M Lantz
Department of Clinical Sciences, Genomics, Diabetes and Endocrinology, Lund University, Malmö, Sweden
Department of Diabetes and Endocrinology, Skåne University Hospital, Malmö, Sweden
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Department of Diabetes and Endocrinology, Skåne University Hospital, Malmö, Sweden
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T Planck
T Planck
Department of Clinical Sciences, Genomics, Diabetes and Endocrinology, Lund University, Malmö, Sweden
Department of Diabetes and Endocrinology, Skåne University Hospital, Malmö, Sweden
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Department of Diabetes and Endocrinology, Skåne University Hospital, Malmö, Sweden
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Introduction Autoimmune thyroid disease is a prerequisite for the development of Graves’ ophthalmopathy (GO), and both thyroid and orbital tissues are infiltrated by immunocompetent cells. The thyroid-stimulating hormone receptor (TSHR) acts
Yue-Yue Wang
Yue-Yue Wang
Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
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Qian Wu
Qian Wu
Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
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Lu Chen
Lu Chen
Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
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Wen Chen
Wen Chen
Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
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Tao Yang
Tao Yang
Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
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Xiao-Quan Xu
Xiao-Quan Xu
Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
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Fei-Yun Wu
Fei-Yun Wu
Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
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Hao Hu
Hao Hu
Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
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Huan-Huan Chen
Huan-Huan Chen
Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
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Introduction Thyroid-associated ophthalmopathy (TAO) is an autoimmune and inflammatory orbital disease ( 1 ). The natural course of TAO is composed of an initial active stage and a later static stage. Systemic immunosuppressive treatment is
Waleed K W Al-Badri
Waleed K W Al-Badri
Orbital center Amsterdam, Department of Ophthalmology, Academic Medical Centre, University of Amsterdam, Amsterdam, the Netherlands
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Hinke Marijke Jellema
Hinke Marijke Jellema
Orbital center Amsterdam, Department of Ophthalmology, Academic Medical Centre, University of Amsterdam, Amsterdam, the Netherlands
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Arnaud R G G Potvin
Arnaud R G G Potvin
Orbital center Amsterdam, Department of Ophthalmology, Academic Medical Centre, University of Amsterdam, Amsterdam, the Netherlands
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Ruth M A van Nispen
Ruth M A van Nispen
Amsterdam University Medical Center, Vrije Universiteit, Department of Ophthalmology, Amsterdam Public Health research institute, Amsterdam, the Netherlands
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Peter H Bisschop
Peter H Bisschop
Department of Endocrinology, Academic Medical Centre, University of Amsterdam, Amsterdam, the Netherlands
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Peerooz Saeed
Peerooz Saeed
Orbital center Amsterdam, Department of Ophthalmology, Academic Medical Centre, University of Amsterdam, Amsterdam, the Netherlands
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) Diplopia No relation No relation No significant association between diplopia and depression/anxiety ( 13 , 80 ) Orbital decompression surgery Significantly improved depression Significantly improved anxiety Significantly improved
Ru-Xuan Zhao
Ru-Xuan Zhao
Department of Endocrinology, Beijing Diabetes Institute, Beijing Tongren Hospital, Capital Medical University, Beijing, China
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Ting-Ting Shi
Ting-Ting Shi
Department of Endocrinology, Beijing Diabetes Institute, Beijing Tongren Hospital, Capital Medical University, Beijing, China
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Sha Luo
Sha Luo
Department of Nuclear Medicine, Beijing Tongren Hospital, Capital Medical University, Beijing, China
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Yun-Fu Liu
Yun-Fu Liu
Department of Radiology, Beijing Tongren Hospital, Capital Medical University, Beijing, China
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Zhong Xin
Zhong Xin
Department of Endocrinology, Beijing Diabetes Institute, Beijing Tongren Hospital, Capital Medical University, Beijing, China
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Jin-Kui Yang
Jin-Kui Yang
Department of Endocrinology, Beijing Diabetes Institute, Beijing Tongren Hospital, Capital Medical University, Beijing, China
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Introduction Graves’ orbitopathy (GO) is an autoimmune disease which frequently arises in patients suffering from Graves’ disease ( 1 , 2 ). GO, often involving both eyes, is one of the most common orbital diseases in adults ( 3 , 4 ). GO
Xiaowen Zhang
Xiaowen Zhang
Department of Endocrinology, Drum Tower Hospital affiliated to Nanjing University Medical School, Branch of National Clinical Research Centre for Metabolic Diseases, Endocrine and Metabolic Disease Medical Center, Drum Tower Hospital affiliated to Nanjing University Medical School, Nanjing, China
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Chen Han
Chen Han
Department of Endocrinology, Drum Tower Hospital affiliated to Nanjing University Medical School, Branch of National Clinical Research Centre for Metabolic Diseases, Endocrine and Metabolic Disease Medical Center, Drum Tower Hospital affiliated to Nanjing University Medical School, Nanjing, China
Department of Endocrinology and Metabolism, Drum Tower Clinical Medical College, Southeast University, Nanjing, China
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Department of Endocrinology and Metabolism, Drum Tower Clinical Medical College, Southeast University, Nanjing, China
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Hongwei Wang
Hongwei Wang
State Key Laboratory of Analytical Chemistry for Life Science & Jiangsu Key Laboratory of Molecular Medicine, Nanjing University School of Medicine, Nanjing, China
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Xinghong Sun
Xinghong Sun
Department of Ophthalmology, Nanjing University Medical School Affiliated Drum Tower Hospital, Nanjing, China
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Xin Dou
Xin Dou
Department of Radiology, Nanjing University Medical School Affiliated Drum Tower Hospital, Nanjing, China
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Xueying He
Xueying He
Department of Radiology, Nanjing University Medical School Affiliated Drum Tower Hospital, Nanjing, China
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Di Wu
Di Wu
Department of Radiology, Southeast University Medical School Affiliated Zhongda Hospital, Nanjing, China
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Shanmei Shen
Shanmei Shen
Department of Endocrinology, Drum Tower Hospital affiliated to Nanjing University Medical School, Branch of National Clinical Research Centre for Metabolic Diseases, Endocrine and Metabolic Disease Medical Center, Drum Tower Hospital affiliated to Nanjing University Medical School, Nanjing, China
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Dalong Zhu
Dalong Zhu
Department of Endocrinology, Drum Tower Hospital affiliated to Nanjing University Medical School, Branch of National Clinical Research Centre for Metabolic Diseases, Endocrine and Metabolic Disease Medical Center, Drum Tower Hospital affiliated to Nanjing University Medical School, Nanjing, China
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Xinlin Zhang
Xinlin Zhang
Department of Cardiology, Nanjing University Medical School Affiliated Drum Tower Hospital, Nanjing, China
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Yan Bi
Yan Bi
Department of Endocrinology, Drum Tower Hospital affiliated to Nanjing University Medical School, Branch of National Clinical Research Centre for Metabolic Diseases, Endocrine and Metabolic Disease Medical Center, Drum Tower Hospital affiliated to Nanjing University Medical School, Nanjing, China
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Introduction Thyroid eye disease (TED), although relatively rare, is the major extrathyroidal manifestation of Graves’ disease (GD). TED is an inflammatory condition affecting the orbit around the eye, with more cases mild and nonprogressive
Bushra Shahida
Bushra Shahida
Department of Clinical Sciences, Genomics, Diabetes and Endocrinology, Lund University, Malmö, Sweden
Department of Diabetes & Endocrinology, Skåne University Hospital, Malmö, Sweden
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Department of Diabetes & Endocrinology, Skåne University Hospital, Malmö, Sweden
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Tereza Planck
Tereza Planck
Department of Clinical Sciences, Genomics, Diabetes and Endocrinology, Lund University, Malmö, Sweden
Department of Diabetes & Endocrinology, Skåne University Hospital, Malmö, Sweden
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Department of Diabetes & Endocrinology, Skåne University Hospital, Malmö, Sweden
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Tania Singh
Tania Singh
Department of Clinical Sciences, Genomics, Diabetes and Endocrinology, Lund University, Malmö, Sweden
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Peter Åsman
Peter Åsman
Department of Clinical Sciences Malmö, Ophthalmology, Lund University, Malmö, Sweden
Department of Ophthalmology, Skåne University Hospital, Malmö, Sweden
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Department of Ophthalmology, Skåne University Hospital, Malmö, Sweden
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Mikael Lantz
Mikael Lantz
Department of Clinical Sciences, Genomics, Diabetes and Endocrinology, Lund University, Malmö, Sweden
Department of Diabetes & Endocrinology, Skåne University Hospital, Malmö, Sweden
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Department of Diabetes & Endocrinology, Skåne University Hospital, Malmö, Sweden
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developing GO ( 4 , 5 , 6 ). GO is a complex autoimmune disease characterized by inflammation in orbital tissue and increased adipogenesis ( 7 ). Inflammation of the orbital tissue includes elevated synthesis of hyaluronic acid by orbital fibroblasts, which
Jakub Supronik
Jakub Supronik
Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland
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Małgorzata Szelachowska
Małgorzata Szelachowska
Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland
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Adam Kretowski
Adam Kretowski
Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland
Clinical Research Centre, Medical University of Bialystok, Bialystok, Poland
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Clinical Research Centre, Medical University of Bialystok, Bialystok, Poland
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Katarzyna Siewko
Katarzyna Siewko
Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland
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clinically relevant cases was 16 per 100,000 in females and 2.9 per 100,000 in males ( 2 , 3 , 4 ). The symptoms of GO include excessive tearing, foreign body sensation, photophobia, and/or pain in the orbit, either resting or gaze evoked. Diplopia
Hathairat Rueangdetnarong
Hathairat Rueangdetnarong
Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
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Rattanaporn Sekararithi
Rattanaporn Sekararithi
Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
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Thidarat Jaiwongkam
Thidarat Jaiwongkam
Cardiac Electrophysiology Research and Training Center (CERT), Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
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Sirinart Kumfu
Sirinart Kumfu
Cardiac Electrophysiology Research and Training Center (CERT), Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
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Nipon Chattipakorn
Nipon Chattipakorn
Cardiac Electrophysiology Research and Training Center (CERT), Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
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Theera Tongsong
Theera Tongsong
Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
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Phudit Jatavan
Phudit Jatavan
Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
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started by adding 100 μL diluted Anti-8-iso-PGF2α antibody to the Goat Anti-Rabbit antibody-coated plate. The sample was incubated for 1 h at 25°C on an orbital shaker and then the antibody solution was removed from the wells. The samples were washed 5
Xiao-Shan Huang
Xiao-Shan Huang
Department of Radiology, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China
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Ning Dai
Ning Dai
Zhejiang Chinese Medical University, Hangzhou, China
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Jian-Xia Xu
Jian-Xia Xu
Department of Radiology, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China
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Jun-Yi Xiang
Jun-Yi Xiang
Department of Radiology, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China
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Xiao-Zhong Zheng
Xiao-Zhong Zheng
Department of Radiology, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China
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Tian-Yu Ke
Tian-Yu Ke
Department of Radiology, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China
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Lin-Ying Ma
Lin-Ying Ma
Department of Radiology, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China
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Qi-Hao Shi
Qi-Hao Shi
Zhejiang Chinese Medical University, Hangzhou, China
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Shu-Feng Fan
Shu-Feng Fan
Department of Radiology, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China
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Yoneda M Takahashi Y Akiyama Y & Awai K . Thyroid-associated orbitopathy: quantitative evaluation of the orbital fat volume and edema using IDEAL-FSE . European Journal of Radiology Open 2019 6 182 – 186 . ( https://doi.org/10.1016/j.ejro.2019
