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M Jensterle, A Podbregar, K Goricar, N Gregoric and A Janez

Introduction Obesity causes functional hypogonadism (FH) due to suppression of hypothalamus-pituitary-testicular (HPT) axis that is potentially reversible ( 1 ). Recent evidence suggests that weight reduction (WR) with lifestyle measures (LSMs

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Anru Wang, Xueqin Yan, Cai Zhang, Caiqi Du, Wenjun Long, Di Zhan and Xiaoping Luo

Introduction The worldwide prevalence of obesity among children and adolescents has increased in past years ( 1 ). Obesity is associated with insulin resistance, type 2 diabetes mellitus (T2DM) and long-term cardiovascular complications

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L Bahler, H J Verberne, E Brakema, R Tepaske, J Booij, J B Hoekstra and F Holleman

. Recently, a quick release variant of bromocriptine has emerged as a new glucose-lowering treatment in obese patients with type 2 diabetes mellitus. Bromocriptine is a centrally acting dopamine D 2 -receptor agonist, but it also weakly stimulates the

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Eliana Piantanida, Daniela Gallo, Giovanni Veronesi, Eugenia Dozio, Eugenia Trotti, Adriana Lai, Silvia Ippolito, Jessica Sabatino, Maria Laura Tanda, Antonio Toniolo, Marco Ferrario and Luigi Bartalena

calcium along with an increase in adipocyte fatty acid synthase and glycerol-3-phosphate dehydrogenase activities and lipolysis inhibition ( 28 ). Metabolic syndrome (MetS) is a multifactorial condition, having central obesity as a causative factor

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Aneta Gawlik, Michael Shmoish, Michaela F Hartmann, Stefan A Wudy, Zbigniew Olczak, Katarzyna Gruszczynska and Ze’ev Hochberg

Introduction Nonsyndromic childhood obesity is associated with nonalcoholic fatty liver disease (NAFLD), a spectrum of conditions, ranging from steatosis to nonalcoholic steatohepatitis (NASH), and various degrees of fibrosis and cirrhosis ( 1

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Maria Giannakou, Katerina Saltiki, Emily Mantzou, Eleni Loukari, Georgios Philippou, Konstantinos Terzidis, Charalampos Stavrianos, Miltiades Kyprianou, Theodora Psaltopoulou, Kalliopi Karatzi and Maria Alevizaki

high oxidative stress is further influenced by obesity and dietary habits in euthyroid women with Hashimoto thyroiditis. Materials and methods This cross-sectional study was conducted in Greece; it involved 218 consecutive euthyroid women with

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Maria Lola Evia-Viscarra, Edel Rafael Rodea-Montero, Evelia Apolinar-Jiménez and Silvia Quintana-Vargas

Introduction A sedentary lifestyle and a diet rich in carbohydrates and fats during childhood leads to obesity. In Mexico, the National Health and Nutrition Survey 2012 data estimate a high prevalence of obesity, defined as a BMI ≥ the 95th

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Jay Toulany, Sebastian D Parlee, Christopher J Sinal, Kathryn Slayter, Shelly McNeil and Kerry B Goralski

Introduction After characterisation as an adipokine by our group in 2007, research concerning chemerin and its relationship to obesity has risen steadily. Chemerin is secreted as an inactive precursor prochemerin, which undergoes processing at

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Thomas Reinehr, Alexandra Kulle, Juliane Rothermel, Caroline Knop-Schmenn, Nina Lass, Christina Bosse and Paul-Martin Holterhus

underlying mechanisms of PCOS are not fully understood yet though obesity and insulin resistance are regarded as major risk factors for hyperandrogenism in PCOS due to abnormal sex steroid production in ovaries and adrenals ( 2 ). Especially, the differential

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Lars Peter Sørensen, Tina Parkner, Esben Søndergaard, Bo Martin Bibby, Holger Jon Møller and Søren Nielsen

Introduction Obesity is a major risk factor for the development of insulin resistance and type 2 diabetes mellitus (T2DM), but the adverse metabolic consequences of obesity vary between individuals (1) . The mechanisms underlying obesity