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Devis Pascut, Sofia Tamini, Silvia Bresolin, Pablo Giraudi, Giuseppe Basso, Alessandro Minocci, Claudio Tiribelli, Graziano Grugni and Alessandro Sartorio

chromosome 15 (UPD15, 20–30% of cases) and imprinting defects (IC, 1–3%) ( 2 ). PWS has an estimated incidence rate of 1 in 15,000 live births ( 3 ), representing the most common syndromic form of life-threatening obesity. The main characteristics of PWS

Open access

L Bahler, H J Verberne, E Brakema, R Tepaske, J Booij, J B Hoekstra and F Holleman

. Recently, a quick release variant of bromocriptine has emerged as a new glucose-lowering treatment in obese patients with type 2 diabetes mellitus. Bromocriptine is a centrally acting dopamine D 2 -receptor agonist, but it also weakly stimulates the

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M Jensterle, A Podbregar, K Goricar, N Gregoric and A Janez

Introduction Obesity causes functional hypogonadism (FH) due to suppression of hypothalamus-pituitary-testicular (HPT) axis that is potentially reversible ( 1 ). Recent evidence suggests that weight reduction (WR) with lifestyle measures (LSMs

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Aneta Gawlik, Michael Shmoish, Michaela F Hartmann, Stefan A Wudy, Zbigniew Olczak, Katarzyna Gruszczynska and Ze’ev Hochberg

Introduction Nonsyndromic childhood obesity is associated with nonalcoholic fatty liver disease (NAFLD), a spectrum of conditions, ranging from steatosis to nonalcoholic steatohepatitis (NASH), and various degrees of fibrosis and cirrhosis ( 1

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Anru Wang, Xueqin Yan, Cai Zhang, Caiqi Du, Wenjun Long, Di Zhan and Xiaoping Luo

Introduction The worldwide prevalence of obesity among children and adolescents has increased in past years ( 1 ). Obesity is associated with insulin resistance, type 2 diabetes mellitus (T2DM) and long-term cardiovascular complications

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Maria Lola Evia-Viscarra, Edel Rafael Rodea-Montero, Evelia Apolinar-Jiménez and Silvia Quintana-Vargas

Introduction A sedentary lifestyle and a diet rich in carbohydrates and fats during childhood leads to obesity. In Mexico, the National Health and Nutrition Survey 2012 data estimate a high prevalence of obesity, defined as a BMI ≥ the 95th

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Thomas Reinehr, Alexandra Kulle, Juliane Rothermel, Caroline Knop-Schmenn, Nina Lass, Christina Bosse and Paul-Martin Holterhus

underlying mechanisms of PCOS are not fully understood yet though obesity and insulin resistance are regarded as major risk factors for hyperandrogenism in PCOS due to abnormal sex steroid production in ovaries and adrenals ( 2 ). Especially, the differential

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Jay Toulany, Sebastian D Parlee, Christopher J Sinal, Kathryn Slayter, Shelly McNeil and Kerry B Goralski

Introduction After characterisation as an adipokine by our group in 2007, research concerning chemerin and its relationship to obesity has risen steadily. Chemerin is secreted as an inactive precursor prochemerin, which undergoes processing at

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Jing Wang, Leishen Wang, Huikun Liu, Shuang Zhang, Junhong Leng, Weiqin Li, Tao Zhang, Nan Li, Wei Li, Andrea A Baccarelli, Lifang Hou and Gang Hu

Introduction The worldwide rise in over-nutrition, sedentary life and obesity has resulted in a steep increase in the number of women who develop gestational diabetes mellitus (GDM) during pregnancy ( 1 ). Nearly 7% of pregnancies in the

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Lars Peter Sørensen, Tina Parkner, Esben Søndergaard, Bo Martin Bibby, Holger Jon Møller and Søren Nielsen

Introduction Obesity is a major risk factor for the development of insulin resistance and type 2 diabetes mellitus (T2DM), but the adverse metabolic consequences of obesity vary between individuals (1) . The mechanisms underlying obesity