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pathway plays a pivotal role. In the thyroid the NOTCH pathway is usually active during the embryonal development and regulates proliferation and differentiation of C-cells ( 11 ). However, it is also well known that the NOTCH pathway is downregulated
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Garcia-Manero G Zweidler-McKay PA . NOTCH pathway activation induces neuroblastoma tumor cell growth arrest . Pediatric Blood and Cancer 2012 58 . ( https://doi.org/10.1002/pbc.23202 ) 12 Aster JC Pear WS Blacklow SC . The varied roles
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) 25 Mao G Jin H Wu L DDX23-Linc00630-HDAC1 axis activates the Notch pathway to promote metastasis . Oncotarget 2017 8 38937 – 38949 . ( https://doi.org/10.18632/oncotarget.17156 ) 26 Uhlmann-Schiffler H Kiermayer S Stahl H The DEAD
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: Gastrointestinal and Liver Physiology 2005 289 G636 – G642 . 167 Pinchot SN Jaskula-Sztul R Ning L Peters NR Cook MR Kunnimalaiyaan M Chen H . Identification and validation of Notch pathway activating compounds through a novel