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M Ingenwerth Institute of Pathology, University Hospital of Essen, University of Duisburg–Essen, Essen, Germany

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T Brandenburg Division of Laboratory Research, Department of Endocrinology, Diabetes and Metabolism and Clinical Chemistry, University Hospital Essen, University of Duisburg-Essen, Germany

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D Führer-Sakel Division of Laboratory Research, Department of Endocrinology, Diabetes and Metabolism and Clinical Chemistry, University Hospital Essen, University of Duisburg-Essen, Germany

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M Goetz Institute of Pathology, University Hospital of Essen, University of Duisburg–Essen, Essen, Germany

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F Weber Department of General, Visceral and Transplantation Surgery, University Hospital Essen, University of Duisburg-Essen, Essen, Germany

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H Dralle Department of General, Visceral and Transplantation Surgery, University Hospital Essen, University of Duisburg-Essen, Essen, Germany

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H-U Schildhaus Institute of Pathology, University Hospital of Essen, University of Duisburg–Essen, Essen, Germany

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K W Schmid Institute of Pathology, University Hospital of Essen, University of Duisburg–Essen, Essen, Germany

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S Theurer Institute of Pathology, University Hospital of Essen, University of Duisburg–Essen, Essen, Germany

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pathway plays a pivotal role. In the thyroid the NOTCH pathway is usually active during the embryonal development and regulates proliferation and differentiation of C-cells ( 11 ). However, it is also well known that the NOTCH pathway is downregulated

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Simonetta Piana Pathology Unit, Azienda USL – IRCCS Reggio Emilia, Reggio Emilia, Italy

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Eleonora Zanetti Pathology Unit, Azienda USL – IRCCS Reggio Emilia, Reggio Emilia, Italy

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Alessandra Bisagni Pathology Unit, Azienda USL – IRCCS Reggio Emilia, Reggio Emilia, Italy

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Alessia Ciarrocchi Laboratory of Translational Research, Azienda USL – IRCCS Reggio Emilia, Reggio Emilia, Italy

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Davide Giordano Otolaryngology Unit, Azienda USL – IRCCS Reggio Emilia, Reggio Emilia, Italy

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Federica Torricelli Laboratory of Translational Research, Azienda USL – IRCCS Reggio Emilia, Reggio Emilia, Italy

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Teresa Rossi Laboratory of Translational Research, Azienda USL – IRCCS Reggio Emilia, Reggio Emilia, Italy

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Moira Ragazzi Pathology Unit, Azienda USL – IRCCS Reggio Emilia, Reggio Emilia, Italy

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Garcia-Manero G Zweidler-McKay PA . NOTCH pathway activation induces neuroblastoma tumor cell growth arrest . Pediatric Blood and Cancer 2012 58 . ( https://doi.org/10.1002/pbc.23202 ) 12 Aster JC Pear WS Blacklow SC . The varied roles

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Jasmin Asberger Department of Obstetrics and Gynecology, Medical Center – University of Freiburg, Freiburg, Germany
Faculty of Medicine, University of Freiburg, Freiburg, Germany

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Thalia Erbes Department of Obstetrics and Gynecology, Medical Center – University of Freiburg, Freiburg, Germany
Faculty of Medicine, University of Freiburg, Freiburg, Germany

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Markus Jaeger Department of Obstetrics and Gynecology, Medical Center – University of Freiburg, Freiburg, Germany
Faculty of Medicine, University of Freiburg, Freiburg, Germany

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Gerta Rücker Institute of Medical Biometry and Statistics, Medical Center – University of Freiburg, Freiburg, Germany

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Claudia Nöthling Department of Obstetrics and Gynecology, Medical Center – University of Freiburg, Freiburg, Germany
Faculty of Medicine, University of Freiburg, Freiburg, Germany

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Andrea Ritter Department of Obstetrics and Gynecology, Medical Center – University of Freiburg, Freiburg, Germany
Faculty of Medicine, University of Freiburg, Freiburg, Germany

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Kai Berner Department of Obstetrics and Gynecology, Medical Center – University of Freiburg, Freiburg, Germany
Faculty of Medicine, University of Freiburg, Freiburg, Germany

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Ingolf Juhasz-Böss Department of Obstetrics and Gynecology, Medical Center – University of Freiburg, Freiburg, Germany
Faculty of Medicine, University of Freiburg, Freiburg, Germany

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Marc Hirschfeld Department of Obstetrics and Gynecology, Medical Center – University of Freiburg, Freiburg, Germany
Faculty of Medicine, University of Freiburg, Freiburg, Germany
Institute of Veterinary Medicine, Georg-August-University Goettingen, Goettingen, Germany

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) 25 Mao G Jin H Wu L DDX23-Linc00630-HDAC1 axis activates the Notch pathway to promote metastasis . Oncotarget 2017 8 38937 – 38949 . ( https://doi.org/10.18632/oncotarget.17156 ) 26 Uhlmann-Schiffler H Kiermayer S Stahl H The DEAD

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E T Aristizabal Prada Department of Internal Medicine IV, Campus Grosshadern, University-Hospital, Ludwig-Maximilians-University of Munich, Munich, Germany

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C J Auernhammer Department of Internal Medicine IV, Campus Grosshadern, University-Hospital, Ludwig-Maximilians-University of Munich, Munich, Germany

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: Gastrointestinal and Liver Physiology 2005 289 G636 – G642 . 167 Pinchot SN Jaskula-Sztul R Ning L Peters NR Cook MR Kunnimalaiyaan M Chen H . Identification and validation of Notch pathway activating compounds through a novel

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