Qian Wang
Qian Wang
Department of Thyroid and Neck Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China
Search for other papers by Qian Wang in
Google Scholar
PubMed
Search for other papers by Qian Wang in
Google Scholar
PubMed
Jiacheng Wang
Jiacheng Wang
Department of Thyroid and Neck Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China
Search for other papers by Jiacheng Wang in
Google Scholar
PubMed
Search for other papers by Jiacheng Wang in
Google Scholar
PubMed
Yunhui Xin
Yunhui Xin
Department of Thyroid and Neck Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China
Search for other papers by Yunhui Xin in
Google Scholar
PubMed
Search for other papers by Yunhui Xin in
Google Scholar
PubMed
Ziyang He
Ziyang He
Department of Thyroid and Neck Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China
Search for other papers by Ziyang He in
Google Scholar
PubMed
Search for other papers by Ziyang He in
Google Scholar
PubMed
Xiang Zhou
Xiang Zhou
Department of Pathology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China
Search for other papers by Xiang Zhou in
Google Scholar
PubMed
Search for other papers by Xiang Zhou in
Google Scholar
PubMed
Xing Liu
Xing Liu
Department of Thyroid and Neck Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China
Search for other papers by Xing Liu in
Google Scholar
PubMed
Search for other papers by Xing Liu in
Google Scholar
PubMed
Teng Zhao
Teng Zhao
Department of Thyroid and Neck Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China
Search for other papers by Teng Zhao in
Google Scholar
PubMed
Search for other papers by Teng Zhao in
Google Scholar
PubMed
Lihan He
Lihan He
Department of Thyroid and Neck Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China
Search for other papers by Lihan He in
Google Scholar
PubMed
Search for other papers by Lihan He in
Google Scholar
PubMed
Hong Shen
Hong Shen
Department of Thyroid and Neck Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China
Search for other papers by Hong Shen in
Google Scholar
PubMed
Search for other papers by Hong Shen in
Google Scholar
PubMed
Mulan Jin
Mulan Jin
Department of Pathology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China
Search for other papers by Mulan Jin in
Google Scholar
PubMed
Search for other papers by Mulan Jin in
Google Scholar
PubMed
Bojun Wei
Bojun Wei
Department of Thyroid and Neck Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China
Search for other papers by Bojun Wei in
Google Scholar
PubMed
Search for other papers by Bojun Wei in
Google Scholar
PubMed
Background
Parathyroid carcinoma (PC), often misdiagnosed as a parathyroid adenoma (PA), is prone to local relapse due to the initial surgery being restricted to parathyroid lesions instead of en bloc resection of parathyroid lesions with negative incision margins. However, it is very challenging to distinguish PC from PA preoperatively; hence, this study investigated an effective biomarker for increasing accuracy in PC diagnosis.
Method
First, the differentially expressed circular RNAs between three PC tissues and three PA tissues were screened by high-throughput circular RNA sequencing, and the expression of hsa_circ_0005729 was verified by qRT-PCR in 14 patients with PC and 40 patients with PA. Secondly, the receiver operating characteristic curve and the area under the curve (AUC) were used to analyze the diagnostic efficiency of hsa_circ_0005729 in PC by combining with laboratory data. Thirdly, RNF138mRNA, the corresponding linear transcript of hsa_circ_0005729, was measured, and the relationship between hsa_circ_0005729 and RNF138 mRNA was analyzed in patients with PA and patients with PC.
Results
Hsa_circ_0005729 expression was significantly higher in patients with PC than in patients with PA. Serum calcium (P = 0.045), alkaline phosphatase (ALP) (P = 0.048), and creatinine levels (P = 0.036) were significantly higher in patients with PC than in patients with PA. The AUC increased to 0.86 when hsa_circ_0005729 combined with serum calcium, creatinine, and ALP. In addition, hsa_circ_0005729 was positively correlated with RNF138 mRNA in patients with PA but not in patients with PC.
Conclusion
The novel circular RNA hsa_circ_0005729 was found to have a higher expression in patients with PC, indicating its usefulness for distinguishing PC from PA.
Qinglei Yin
Qinglei Yin
Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Guangdong Geriatric Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China
Search for other papers by Qinglei Yin in
Google Scholar
PubMed
Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Guangdong Geriatric Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China
Search for other papers by Qinglei Yin in
Google Scholar
PubMed
Zhou Jin
Zhou Jin
Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Search for other papers by Zhou Jin in
Google Scholar
PubMed
Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Search for other papers by Zhou Jin in
Google Scholar
PubMed
Yulin Zhou
Yulin Zhou
Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Search for other papers by Yulin Zhou in
Google Scholar
PubMed
Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Search for other papers by Yulin Zhou in
Google Scholar
PubMed
Dalong Song
Dalong Song
Guangdong Geriatric Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China
Reproductive Medicine Center, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China
Search for other papers by Dalong Song in
Google Scholar
PubMed
Reproductive Medicine Center, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China
Search for other papers by Dalong Song in
Google Scholar
PubMed
Chenyang Fu
Chenyang Fu
Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Search for other papers by Chenyang Fu in
Google Scholar
PubMed
Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Search for other papers by Chenyang Fu in
Google Scholar
PubMed
FengJiao Huang
FengJiao Huang
Reproductive Medicine Center, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China
Division of Endocrinology, Department of Internal Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China
Search for other papers by FengJiao Huang in
Google Scholar
PubMed
Division of Endocrinology, Department of Internal Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China
Search for other papers by FengJiao Huang in
Google Scholar
PubMed
Shu Wang
Shu Wang
Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Search for other papers by Shu Wang in
Google Scholar
PubMed
Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Search for other papers by Shu Wang in
Google Scholar
PubMed
system . Circulation Research 2018 122 399 – 401 . ( https://doi.org/10.1161/CIRCRESAHA.117.312512 ) 13 Mercer TR Dinger ME Mattick JS Long non-coding RNAs: insights into functions . Nature Reviews: Genetics 2009 10 155 – 159
Jiwen Yang
Jiwen Yang
Department of Nuclear Medicine, Yijishan Hospital of Wannan Medical College, Wuhu City, Anhui Province, China
Search for other papers by Jiwen Yang in
Google Scholar
PubMed
Search for other papers by Jiwen Yang in
Google Scholar
PubMed
Yayin Huang
Yayin Huang
Department of Clinical Laboratory, The Second People’s Hospital of Wuhu, Wuhu City, Anhui Province, China
Search for other papers by Yayin Huang in
Google Scholar
PubMed
Search for other papers by Yayin Huang in
Google Scholar
PubMed
Bohan Dong
Bohan Dong
Department of Biochemistry and Molecular Biology, Wannan Medical College, Wuhu City, Anhui Province, China
Search for other papers by Bohan Dong in
Google Scholar
PubMed
Search for other papers by Bohan Dong in
Google Scholar
PubMed
Yunhai Dai
Yunhai Dai
Department of Nuclear Medicine, Yijishan Hospital of Wannan Medical College, Wuhu City, Anhui Province, China
Search for other papers by Yunhai Dai in
Google Scholar
PubMed
Search for other papers by Yunhai Dai in
Google Scholar
PubMed
Wang Z A long non-coding RNA, PTCSC3, as a tumor suppressor and a target of miRNAs in thyroid cancer cells . Experimental and Therapeutic Medicine 2013 5 1143 – 1146 . ( https://doi.org/10.3892/etm.2013.933 ) 3 Eades G Zhang YS Li QL
Anna-Pauliina Iivonen
Anna-Pauliina Iivonen
Institute of Biomedicine/Physiology, Biomedicum Helsinki and Stem Cells and Metabolism Research Program, University of Helsinki, Helsinki, Finland
Search for other papers by Anna-Pauliina Iivonen in
Google Scholar
PubMed
Search for other papers by Anna-Pauliina Iivonen in
Google Scholar
PubMed
Johanna Känsäkoski
Johanna Känsäkoski
Institute of Biomedicine/Physiology, Biomedicum Helsinki and Stem Cells and Metabolism Research Program, University of Helsinki, Helsinki, Finland
Search for other papers by Johanna Känsäkoski in
Google Scholar
PubMed
Search for other papers by Johanna Känsäkoski in
Google Scholar
PubMed
Kirsi Vaaralahti
Kirsi Vaaralahti
Institute of Biomedicine/Physiology, Biomedicum Helsinki and Stem Cells and Metabolism Research Program, University of Helsinki, Helsinki, Finland
Search for other papers by Kirsi Vaaralahti in
Google Scholar
PubMed
Search for other papers by Kirsi Vaaralahti in
Google Scholar
PubMed
Taneli Raivio
Taneli Raivio
Institute of Biomedicine/Physiology, Biomedicum Helsinki and Stem Cells and Metabolism Research Program, University of Helsinki, Helsinki, Finland
New Children’s Hospital, Pediatric Research Center, Helsinki University Hospital, Helsinki, Finland
Search for other papers by Taneli Raivio in
Google Scholar
PubMed
New Children’s Hospital, Pediatric Research Center, Helsinki University Hospital, Helsinki, Finland
Search for other papers by Taneli Raivio in
Google Scholar
PubMed
against the human reference genome (GRCh38) with the BLAT ( 12 ) and BLASTN ( 13 ) tools in Ensembl database ( 14 ). The BLAT search was run with ‘Genomic sequence’ and the BLASTN search with ‘Ensembl Non-coding RNA genes’ as DNA databases. In both
Tian Zhou
Tian Zhou
School of Clinical Medicine, GuiZhou Medical University, Guiyang, Guizhou, China
Department of Breast Surgery, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China
Search for other papers by Tian Zhou in
Google Scholar
PubMed
Department of Breast Surgery, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China
Search for other papers by Tian Zhou in
Google Scholar
PubMed
Dai-wei Zhao
Dai-wei Zhao
School of Clinical Medicine, GuiZhou Medical University, Guiyang, Guizhou, China
Department of Surgery, Second People's Hospital of Guizhou Province, Guiyang, Guizhou, China
Search for other papers by Dai-wei Zhao in
Google Scholar
PubMed
Department of Surgery, Second People's Hospital of Guizhou Province, Guiyang, Guizhou, China
Search for other papers by Dai-wei Zhao in
Google Scholar
PubMed
Ning Ma
Ning Ma
School of Clinical Medicine, GuiZhou Medical University, Guiyang, Guizhou, China
Search for other papers by Ning Ma in
Google Scholar
PubMed
Search for other papers by Ning Ma in
Google Scholar
PubMed
Xue-ying Zhu
Xue-ying Zhu
School of Clinical Medicine, GuiZhou Medical University, Guiyang, Guizhou, China
Search for other papers by Xue-ying Zhu in
Google Scholar
PubMed
Search for other papers by Xue-ying Zhu in
Google Scholar
PubMed
Xing-hong Chen
Xing-hong Chen
Department of Surgery, Second People's Hospital of Guizhou Province, Guiyang, Guizhou, China
Search for other papers by Xing-hong Chen in
Google Scholar
PubMed
Search for other papers by Xing-hong Chen in
Google Scholar
PubMed
Xue Luo
Xue Luo
Department of Breast Surgery, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China
Search for other papers by Xue Luo in
Google Scholar
PubMed
Search for other papers by Xue Luo in
Google Scholar
PubMed
Song Chen
Song Chen
School of Clinical Medicine, GuiZhou Medical University, Guiyang, Guizhou, China
Search for other papers by Song Chen in
Google Scholar
PubMed
Search for other papers by Song Chen in
Google Scholar
PubMed
Qing-jun Gao
Qing-jun Gao
Department of Thyroid Surgery, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China
Search for other papers by Qing-jun Gao in
Google Scholar
PubMed
Search for other papers by Qing-jun Gao in
Google Scholar
PubMed
from the TCGA dataset and compared in tumor and normal groups ( 21 ). Analysis of the potential relationship between long non-coding RNA forkhead box P4–antisense RNA 1 and forkhead box P4 The relationship between long non-coding RNA (lncRNA
Helene Bandsholm Leere Tallaksen
Helene Bandsholm Leere Tallaksen
Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark
Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark
Department of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark
Search for other papers by Helene Bandsholm Leere Tallaksen in
Google Scholar
PubMed
Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark
Department of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark
Search for other papers by Helene Bandsholm Leere Tallaksen in
Google Scholar
PubMed
Emma B Johannsen
Emma B Johannsen
Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark
Department of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark
Search for other papers by Emma B Johannsen in
Google Scholar
PubMed
Department of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark
Search for other papers by Emma B Johannsen in
Google Scholar
PubMed
Jesper Just
Jesper Just
Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark
Department of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark
Search for other papers by Jesper Just in
Google Scholar
PubMed
Department of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark
Search for other papers by Jesper Just in
Google Scholar
PubMed
Mette Hansen Viuff
Mette Hansen Viuff
Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark
Department of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark
Department of Gynaecology and Obstetrics, Aarhus University Hospital, Aarhus, Denmark
Search for other papers by Mette Hansen Viuff in
Google Scholar
PubMed
Department of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark
Department of Gynaecology and Obstetrics, Aarhus University Hospital, Aarhus, Denmark
Search for other papers by Mette Hansen Viuff in
Google Scholar
PubMed
Claus H Gravholt
Claus H Gravholt
Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark
Department of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark
Department of Endocrinology, Aarhus University Hospital, Aarhus, Denmark
Search for other papers by Claus H Gravholt in
Google Scholar
PubMed
Department of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark
Department of Endocrinology, Aarhus University Hospital, Aarhus, Denmark
Search for other papers by Claus H Gravholt in
Google Scholar
PubMed
Anne Skakkebæk
Anne Skakkebæk
Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark
Department of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark
Department of Clinical Genetics, Aarhus University Hospital, Aarhus, Denmark
Search for other papers by Anne Skakkebæk in
Google Scholar
PubMed
Department of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark
Department of Clinical Genetics, Aarhus University Hospital, Aarhus, Denmark
Search for other papers by Anne Skakkebæk in
Google Scholar
PubMed
hypermethylation in KS, and with DEGs displaying an inverse expression pattern in TS and KS, respectively. Furthermore, the altered transcriptome seen in SCAs does not only include coding RNAs. Also, autosomal and X chromosomal non-coding RNAs (e.g. microRNAs
Hui Li
Hui Li
Department of Thyroid Surgery, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University/Hunan Cancer Hospital, Changsha, Hunan, P. R. China.
Search for other papers by Hui Li in
Google Scholar
PubMed
Search for other papers by Hui Li in
Google Scholar
PubMed
Peng Wu
Peng Wu
Department of Thyroid Surgery, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University/Hunan Cancer Hospital, Changsha, Hunan, P. R. China.
Search for other papers by Peng Wu in
Google Scholar
PubMed
Search for other papers by Peng Wu in
Google Scholar
PubMed
various diseases, including thyroid cancer ( 3 , 4 ). This regulation includes DNA methylation, chromatin remodeling, histone modifications, and the expression of diverse non-coding RNAs (ncRNAs), such as microRNAs (miRNAs), long ncRNAs (lncRNAs), and
Yu Lin
Yu Lin
State Key Laboratory of Reproductive Medicine, Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, People’s Republic of China
Search for other papers by Yu Lin in
Google Scholar
PubMed
Search for other papers by Yu Lin in
Google Scholar
PubMed
Yingying Zhang
Yingying Zhang
State Key Laboratory of Reproductive Medicine, Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, People’s Republic of China
Search for other papers by Yingying Zhang in
Google Scholar
PubMed
Search for other papers by Yingying Zhang in
Google Scholar
PubMed
Lei Xu
Lei Xu
Maternal and Child Health Care Hospital of Dongchangfu District, Liaocheng, People’s Republic of China
Search for other papers by Lei Xu in
Google Scholar
PubMed
Search for other papers by Lei Xu in
Google Scholar
PubMed
Wei Long
Wei Long
State Key Laboratory of Reproductive Medicine, Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, People’s Republic of China
Search for other papers by Wei Long in
Google Scholar
PubMed
Search for other papers by Wei Long in
Google Scholar
PubMed
Chunjian Shan
Chunjian Shan
State Key Laboratory of Reproductive Medicine, Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, People’s Republic of China
Search for other papers by Chunjian Shan in
Google Scholar
PubMed
Search for other papers by Chunjian Shan in
Google Scholar
PubMed
Hongjuan Ding
Hongjuan Ding
State Key Laboratory of Reproductive Medicine, Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, People’s Republic of China
Search for other papers by Hongjuan Ding in
Google Scholar
PubMed
Search for other papers by Hongjuan Ding in
Google Scholar
PubMed
Lianghui You
Lianghui You
State Key Laboratory of Reproductive Medicine, Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, People’s Republic of China
Search for other papers by Lianghui You in
Google Scholar
PubMed
Search for other papers by Lianghui You in
Google Scholar
PubMed
Chun Zhao
Chun Zhao
State Key Laboratory of Reproductive Medicine, Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, People’s Republic of China
Search for other papers by Chun Zhao in
Google Scholar
PubMed
Search for other papers by Chun Zhao in
Google Scholar
PubMed
Zhonghua Shi
Zhonghua Shi
State Key Laboratory of Reproductive Medicine, Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, People’s Republic of China
Search for other papers by Zhonghua Shi in
Google Scholar
PubMed
Search for other papers by Zhonghua Shi in
Google Scholar
PubMed
Hung T Argani P Rinn JL et al . Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis . Nature 2010 464 1071 – 1076 . ( https://doi.org/10.1038/nature08975 ) 10 Klattenhoff CA Scheuermann JC Surface LE
Bingbing Wang
Bingbing Wang
Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology and Reproductive Sciences, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA
Search for other papers by Bingbing Wang in
Google Scholar
PubMed
Search for other papers by Bingbing Wang in
Google Scholar
PubMed
Mayra Cruz Ithier
Mayra Cruz Ithier
Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology and Reproductive Sciences, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA
Search for other papers by Mayra Cruz Ithier in
Google Scholar
PubMed
Search for other papers by Mayra Cruz Ithier in
Google Scholar
PubMed
Nataliya Parobchak
Nataliya Parobchak
Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology and Reproductive Sciences, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA
Search for other papers by Nataliya Parobchak in
Google Scholar
PubMed
Search for other papers by Nataliya Parobchak in
Google Scholar
PubMed
Stacy M Yadava
Stacy M Yadava
Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology and Reproductive Sciences, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA
Search for other papers by Stacy M Yadava in
Google Scholar
PubMed
Search for other papers by Stacy M Yadava in
Google Scholar
PubMed
Jay Schulkin
Jay Schulkin
Department of Obstetrics, Gynecology, University of Washington, Seattle, Washington, USA
Search for other papers by Jay Schulkin in
Google Scholar
PubMed
Search for other papers by Jay Schulkin in
Google Scholar
PubMed
Todd Rosen
Todd Rosen
Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology and Reproductive Sciences, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA
Search for other papers by Todd Rosen in
Google Scholar
PubMed
Search for other papers by Todd Rosen in
Google Scholar
PubMed
cellular process examined so far ( 21 ). As shown in Table 1 , there were a total of 1586 genomic sites targeted by 1,25(OH)2D-simulated VDR in human STB, which include 1112 sites for non-coding RNA genes and 148 for coding genes. Remarkably, 1,25(OH)2D
Veronica Astro
Veronica Astro
Biological and Environmental Science and Engineering Division, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia
Search for other papers by Veronica Astro in
Google Scholar
PubMed
Search for other papers by Veronica Astro in
Google Scholar
PubMed
Elisabetta Fiacco
Elisabetta Fiacco
Biological and Environmental Science and Engineering Division, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia
Search for other papers by Elisabetta Fiacco in
Google Scholar
PubMed
Search for other papers by Elisabetta Fiacco in
Google Scholar
PubMed
Kelly Johanna Cardona-Londoño
Kelly Johanna Cardona-Londoño
Biological and Environmental Science and Engineering Division, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia
Search for other papers by Kelly Johanna Cardona-Londoño in
Google Scholar
PubMed
Search for other papers by Kelly Johanna Cardona-Londoño in
Google Scholar
PubMed
Ilario De Toma
Ilario De Toma
Sequentia Biotech SL, Barcelona, Spain
Search for other papers by Ilario De Toma in
Google Scholar
PubMed
Search for other papers by Ilario De Toma in
Google Scholar
PubMed
Hams Saeed Alzahrani
Hams Saeed Alzahrani
Department of Genetic Medicine, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia
Search for other papers by Hams Saeed Alzahrani in
Google Scholar
PubMed
Search for other papers by Hams Saeed Alzahrani in
Google Scholar
PubMed
Jumana Alama
Jumana Alama
Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia
Search for other papers by Jumana Alama in
Google Scholar
PubMed
Search for other papers by Jumana Alama in
Google Scholar
PubMed
Amal Kokandi
Amal Kokandi
Department of Dermatology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia
Search for other papers by Amal Kokandi in
Google Scholar
PubMed
Search for other papers by Amal Kokandi in
Google Scholar
PubMed
Taha Abo-Almagd Abdel-Meguid Hamoda
Taha Abo-Almagd Abdel-Meguid Hamoda
Department of Urology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia
Search for other papers by Taha Abo-Almagd Abdel-Meguid Hamoda in
Google Scholar
PubMed
Search for other papers by Taha Abo-Almagd Abdel-Meguid Hamoda in
Google Scholar
PubMed
Majed Felemban
Majed Felemban
Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia
Center of Innovation in Personalized Medicine, King Abdulaziz University, Jeddah, Saudi Arabia
Search for other papers by Majed Felemban in
Google Scholar
PubMed
Center of Innovation in Personalized Medicine, King Abdulaziz University, Jeddah, Saudi Arabia
Search for other papers by Majed Felemban in
Google Scholar
PubMed
Antonio Adamo
Antonio Adamo
Biological and Environmental Science and Engineering Division, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia
Search for other papers by Antonio Adamo in
Google Scholar
PubMed
Search for other papers by Antonio Adamo in
Google Scholar
PubMed
extra X chromosome in all the established KS-iPSC clones and a normal chromosomal content in the iPSCs obtained from the 46,XY donor (Supplementary Fig. 1). Next, we assessed the mRNA levels of the long non-coding RNA (lncRNA) XIST in KS and 46,XY
