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Introduction Neuron-specific enolase (NSE) is a dimer characterised by the presence of a neuron-specific γ subunit. NSE is one of the isoenzymes of enolase, classified as a glycolytic enzyme. The biological half-life of this isoenzyme is
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assessment with respect to the neuron-specific enolase (NSE) in the diagnosis of NF-pNETs with the best cut-off value. Here, we present the clinical characteristics of NF-pNETs and the clinical value of serum CgA measurement in the evaluation of the
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, nondiabetic NET patients ( N =28) and age- (±3 years) and sex-matched nonobese, nondiabetic controls ( N =28); and (ii) study the relationship between AG, UAG, and AG/UAG ratios and biochemical (chromogranin-A (CgA) and neuron-specific enolase (NSE) levels
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neuron-specific enolase as prognostic markers in patients with advanced pnet treated with everolimus . Journal of Clinical Endocrinology and Metabolism 2011 96 3741 – 3749 . ( doi:10.1210/jc.2011-0666 ) 32 Lawrence B Gustafsson BI Kidd
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) by a decrease of at least 1 point. Biological response was reported for both neuron-specific enolase (NSE) and alkaline phosphatase (ALP), in patients with high baseline levels of NSE/ALP, as a >30% decrease in level compared to baseline
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biomarkers for both prognostic and diagnostic purposes (e.g. 5-hydroxyindoleacetic acid, neuron-specific enolase, chromogranin A (CgA), and beta subunit of human chorionic gonadotropin) ( 5 , 6 , 7 , 8 ). Identification of an optimal biomarker for a given
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Wren Laboratories, Yale University School of Medicine, 35 NE Industrial Road, Branford, Connecticut, USA
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date, the use of either single-specific tumor products (e.g. serotonin, PP, and neuron specific enolase (NSE)) or a general marker of neuroendocrine secretion (CgA) has not met the rigorous criteria to be considered optimally effective in attaining
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and neuron-specific enolase as prognostic markers in patients with advanced pNET treated with everolimus . Journal of Clinical Endocrinology and Metabolism 2011 96 3741 – 3749 . ( doi:10.1210/jc.2011-0666 ). 19 De Martino MC van Koetsveld PM
Waikato Clinical Campus, University of Auckland, Hamilton, New Zealand
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for neuroendocrine differentiation were positive (CD56, synaptophysin, neuron-specific enolase (NSE)), as was TTF-1. The Ki-67 (MIB-1) proliferation index was estimated as 35–45% (WHO grade 3) and weak positive staining for ACTH was present. Staining
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Specific Enolase (NSE) was 16.6 ± 6.1 µg/L, for a normal upper limit of 13 µg/L. Laboratory values for 5-HIAA, Gastrin, Insulin, Glucagon and Serotonin were available in less than 4 patients. Surgery and pathological staging Overall, 63.7% of the