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V G Pluimakers Princess Máxima Centre for Paediatric Oncology, Utrecht, The Netherlands

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M van Waas Department of Paediatric Oncology/Haematology, Erasmus MC–Sophia Children’s Hospital, Rotterdam, The Netherlands

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C W N Looman Department of Public Health, Erasmus MC, Rotterdam, The Netherlands

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M P de Maat Department of Haematology, Erasmus MC, Rotterdam, The Netherlands

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R de Jonge Department of Clinical Chemistry, Erasmus MC, Rotterdam, The Netherlands

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P Delhanty Section Endocrinology, Department of Medicine, Erasmus MC, Rotterdam, The Netherlands

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M Huisman Section Endocrinology, Department of Medicine, Erasmus MC, Rotterdam, The Netherlands

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F U S Mattace-Raso Section Geriatric Medicine, Department of Medicine, Erasmus MC, Rotterdam, The Netherlands

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M M van den Heuvel-Eibrink Princess Máxima Centre for Paediatric Oncology, Utrecht, The Netherlands

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S J C M M Neggers Princess Máxima Centre for Paediatric Oncology, Utrecht, The Netherlands
Section Endocrinology, Department of Medicine, Erasmus MC, Rotterdam, The Netherlands

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Introduction Over the past decades, survival rates of childhood nephroblastoma and neuroblastoma have increased to respectively ~90% and ~40–95% (strongly dependent on stadium) ( 1 , 2 ). These tumours are of embryonic origin, with a peak

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-20-0144
Volume/Issue:
Volume 9: Issue 7
Open access
Catherine Cardot Bauters CHU Lille, Service d’Endocrinologie, Diabétologie, Métabolisme-Nutrition, Hôpital Claude Huriez, Lille, France

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Emmanuelle Leteurtre Univ. Lille, Inserm, CHU Lille, UMR-S 1277-CANTHER, Cancer Heterogeneity, Plasticity & Resistance to Therapies, Lille, France

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Bruno Carnaille CHU Lille, Service de Chirurgie Endocrine, Hôpital Claude Huriez, Lille, France

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Christine Do Cao CHU Lille, Service d’Endocrinologie, Diabétologie, Métabolisme-Nutrition, Hôpital Claude Huriez, Lille, France

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Stéphanie Espiard CHU Lille, Service d’Endocrinologie, Diabétologie, Métabolisme-Nutrition, Hôpital Claude Huriez, Lille, France

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Malo Penven CHU Lille, Service de Biochimie Hormonologie, Métabolisme, Nutrition-Oncologie, Centre de Biologie Pathologie Génétique, Lille, France

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Evelyne Destailleur CHU Lille, Service de Biochimie Hormonologie, Métabolisme, Nutrition-Oncologie, Centre de Biologie Pathologie Génétique, Lille, France

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Isabelle Szuster CHU Lille, Service de Biochimie Hormonologie, Métabolisme, Nutrition-Oncologie, Centre de Biologie Pathologie Génétique, Lille, France

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Tonio Lovecchio CHU Lille, Service de Biochimie Hormonologie, Métabolisme, Nutrition-Oncologie, Centre de Biologie Pathologie Génétique, Lille, France

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Julie Leclerc Univ. Lille, Inserm, CHU Lille, UMR-S 1277-CANTHER, Cancer Heterogeneity, Plasticity & Resistance to Therapies, Lille, France
CHU Lille, Service de Biochimie Hormonologie, Métabolisme, Nutrition-Oncologie, Centre de Biologie Pathologie Génétique, Lille, France

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Fredéric Frénois Univ. Lille, CHU Lille, EA-7364 RADEME, Faculté de Médecine, Lille, France

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Emmanuel Esquivel Dept Medicine, Mays Cancer Center, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA

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Patricia L M Dahia Dept Medicine, Mays Cancer Center, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA

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Emilie Ait-Yahya CHU Lille, Institut de Biochimie & Biologie Moléculaire, Centre de Biologie Pathologie Génétique, Lille, France

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Michel Crépin CHU Lille, Service de Biochimie Hormonologie, Métabolisme, Nutrition-Oncologie, Centre de Biologie Pathologie Génétique, Lille, France

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Pascal Pigny CHU Lille, Service de Biochimie Hormonologie, Métabolisme, Nutrition-Oncologie, Centre de Biologie Pathologie Génétique, Lille, France

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the ability of KIF1Bβ to promote the apoptosis of primary rat sympathetic neurons ( 3 ) and thus may facilitate tumorigenesis later on. Conversely enforced expression of KIF1B resulted in an induction of apoptosis of neuroblastoma (NB) cells ( 4

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-20-0460
Volume/Issue:
Volume 9: Issue 10
Open access
Chanyang Kim Department of Biomedical Science, Graduate School, Kyung Hee University, Seoul, Korea

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Seungjoon Park Department of Pharmacology and Medical Research Center for Bioreaction to ROS and Biomedical Science Institute, School of Medicine, Kyung Hee University, Seoul, Korea

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caspase cascade ( 8 ). It has been shown that MPP + produces oxidative stress, mitochondrial dysfunction and apoptosis in human neuroblastoma cell line SH-SY5Y ( 9 , 10 , 11 ). Therefore, the molecules targeting pharmacological intervention of

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-17-0350
Volume/Issue:
Volume 7: Issue 3
Open access
Jingci Chen Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

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Yan Wu Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

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Pengyan Wang Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

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Huanwen Wu Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

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Anli Tong Department of Endocrinology, Key Laboratory of Endocrinology, National Health Commission of the People’s Republic of China, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

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Xiaoyan Chang Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

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, including ganglioneuroma (GN), neuroblastoma, ganglioneuroblastoma, etc ( 1 , 2 ). Currently, little is known about its pathogenesis and relationship with its pure tumor counterparts. Comstock et al. investigated the N- myc amplification status in CP

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-21-0300
Volume/Issue:
Volume 10: Issue 8
Open access
Wafaa M Rashed Research Department, Children’s Cancer Hospital Egypt (CCHE-57357), Cairo, Egypt
Armed Forces College of Medicine, Cairo, Egypt

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Anas Saad Faculty of Medicine, Damascus University, Damascus, Syria

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Muneer Al-Husseini Faculty of Medicine, Ain Shams University, Cairo, Egypt

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Ahmed Mahmoud Galal Armed Forces College of Medicine, Cairo, Egypt

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Assem Mohamed Ismael Armed Forces College of Medicine, Cairo, Egypt

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Ahmed M Al-Tayep Armed Forces College of Medicine, Cairo, Egypt

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Ayman El Shafie Armed Forces College of Medicine, Cairo, Egypt

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Mahmoud Ahmed Ali Armed Forces College of Medicine, Cairo, Egypt

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Ahmad Samir Alfaar Charité – Universitätsmedizin Berlin, Campus Virchow Klinikum, Ophthalmology Department, Berlin, Germany

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only. However, we noticed that the latencies between the first and second adrenal gland tumor in these four cases were reasonably long (21–175 months). Neuroblastoma is the third most common malignancy in pediatrics, but little is known about

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-18-0304
Volume/Issue:
Volume 7: Issue 10
Open access
Jean-Benoît Corcuff Department of Nuclear Medicine, Haut Lévêque Hospital, Pessac, France
Nutrition et Neurobiologie intégrée, UMR 1286, University of Bordeaux, Bordeaux, France
Groupe de Biologie Spécialisée, Société Française de Médecine Nucléaire, Paris, France

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Laurence Chardon Department of Biochemistry, Edouard Herriot Hospital, Lyon, France

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Ines El Hajji Ridah Biomnis, Lyon, France

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Julie Brossaud Department of Nuclear Medicine, Haut Lévêque Hospital, Pessac, France
Nutrition et Neurobiologie intégrée, UMR 1286, University of Bordeaux, Bordeaux, France
Groupe de Biologie Spécialisée, Société Française de Médecine Nucléaire, Paris, France

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tryptophan thereby reducing urinary 5HIAA ( 71 ). Urinary metabolites of catecholamines, metanephrines To biologically diagnose pheochromocytomas or paragangliomas or neuroblastomas, various tumour-related markers might be assayed ( 72 , 73 , 74

Article Type:
Review Article
DOI:
https://doi.org/10.1530/EC-17-0071
Volume/Issue:
Volume 6: Issue 6
Open access
Thiago U Pantaleão Laboratório de Fisiologia Endócrina Doris Rosenthal, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

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Andrea C F Ferreira Laboratório de Fisiologia Endócrina Doris Rosenthal, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
NUMPEX, Pólo de Xerém, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

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Maria C S Santos Laboratório de Fisiologia Endócrina Doris Rosenthal, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

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Álvaro S P Figueiredo Laboratório de Fisiologia Endócrina Doris Rosenthal, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

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Ruy A N Louzada Laboratório de Fisiologia Endócrina Doris Rosenthal, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

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Doris Rosenthal Laboratório de Fisiologia Endócrina Doris Rosenthal, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

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Denise P Carvalho Laboratório de Fisiologia Endócrina Doris Rosenthal, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

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Vânia M Corrêa da Costa Laboratório de Fisiologia Endócrina Doris Rosenthal, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

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in both mouse neuroblastoma cell line ( 7 ) and rat pituitary tumor cell line ( 8 ). In mice, maternal exposure to methylmercury was able to inhibit D3 activity in the brain of newborns, but D2 activity was not affected ( 9 ) Sulkowski and coworkers

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-17-0220
Volume/Issue:
Volume 6: Issue 8
Open access
Selina Mäkinen Minerva Foundation Institute for Medical Research, Helsinki, Finland
Department of Medicine, University of Helsinki, Helsinki University Central Hospital, Helsinki, Finland

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Neeta Datta Minerva Foundation Institute for Medical Research, Helsinki, Finland
Department of Medicine, University of Helsinki, Helsinki University Central Hospital, Helsinki, Finland

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Yen H Nguyen Minerva Foundation Institute for Medical Research, Helsinki, Finland
Department of Medicine, University of Helsinki, Helsinki University Central Hospital, Helsinki, Finland

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Petro Kyrylenko Minerva Foundation Institute for Medical Research, Helsinki, Finland
Department of Medicine, University of Helsinki, Helsinki University Central Hospital, Helsinki, Finland

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Markku Laakso Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland

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Heikki A Koistinen Minerva Foundation Institute for Medical Research, Helsinki, Finland
Department of Medicine, University of Helsinki, Helsinki University Central Hospital, Helsinki, Finland

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study where simvastatin reduced glycolysis and glycolytic capacity in neuroblastoma cells ( 34 ). Statins have been implicated with impaired mitochondrial function in several studies ( 16 , 17 , 35 ). Lactone-form statins, including lactone

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-20-0444
Volume/Issue:
Volume 9: Issue 11
Open access
Jasmin Asberger Department of Obstetrics and Gynecology, Medical Center – University of Freiburg, Freiburg, Germany
Faculty of Medicine, University of Freiburg, Freiburg, Germany

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Thalia Erbes Department of Obstetrics and Gynecology, Medical Center – University of Freiburg, Freiburg, Germany
Faculty of Medicine, University of Freiburg, Freiburg, Germany

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Markus Jaeger Department of Obstetrics and Gynecology, Medical Center – University of Freiburg, Freiburg, Germany
Faculty of Medicine, University of Freiburg, Freiburg, Germany

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Gerta Rücker Institute of Medical Biometry and Statistics, Medical Center – University of Freiburg, Freiburg, Germany

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Claudia Nöthling Department of Obstetrics and Gynecology, Medical Center – University of Freiburg, Freiburg, Germany
Faculty of Medicine, University of Freiburg, Freiburg, Germany

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Andrea Ritter Department of Obstetrics and Gynecology, Medical Center – University of Freiburg, Freiburg, Germany
Faculty of Medicine, University of Freiburg, Freiburg, Germany

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Kai Berner Department of Obstetrics and Gynecology, Medical Center – University of Freiburg, Freiburg, Germany
Faculty of Medicine, University of Freiburg, Freiburg, Germany

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Ingolf Juhasz-Böss Department of Obstetrics and Gynecology, Medical Center – University of Freiburg, Freiburg, Germany
Faculty of Medicine, University of Freiburg, Freiburg, Germany

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Marc Hirschfeld Department of Obstetrics and Gynecology, Medical Center – University of Freiburg, Freiburg, Germany
Faculty of Medicine, University of Freiburg, Freiburg, Germany
Institute of Veterinary Medicine, Georg-August-University Goettingen, Goettingen, Germany

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protein level. In parallel, a similar effect could be observed regarding cyclin D1 mRNA expression, which also characterizes as a proliferation marker. DDX1 expression has been associated with different types of tumours including neuroblastoma ( 27

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-20-0281
Volume/Issue:
Volume 9: Issue 12
Open access
Sara Storvall Department of Endocrinology, Abdominal Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland

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Helena Leijon Department of Pathology and Huslab, University of Helsinki and Helsinki University Hospital, Helsinki, Finland

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Eeva Ryhänen Department of Endocrinology, Abdominal Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland

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Johanna Louhimo Department of Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland

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Caj Haglund Department of Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland

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Camilla Schalin-Jäntti Department of Endocrinology, Abdominal Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland

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Johanna Arola Department of Pathology and Huslab, University of Helsinki and Helsinki University Hospital, Helsinki, Finland

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demonstrated in different NETs including pituitary adenomas, GEP-NETs, pheochromocytomas and paragangliomas, neuroblastoma, Merkel cell carcinoma and medullary thyroid carcinoma ( 38 ). Most previous studies have focused on membrane expression. We recently

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-19-0260
Volume/Issue:
Volume 8: Issue 8
Open access