Ulrik Ø Andersen
Ulrik Ø Andersen
Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark
Institute of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Institute of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Dijana Terzic
Dijana Terzic
Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark
Institute of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Institute of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Nicolai Jacob Wewer Albrechtsen
Nicolai Jacob Wewer Albrechtsen
Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark
Institute of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Novo Nordisk Foundation Centre for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Institute of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Novo Nordisk Foundation Centre for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Peter Dall Mark
Peter Dall Mark
Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark
Institute of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Institute of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Peter Plomgaard
Peter Plomgaard
Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Jens F Rehfeld
Jens F Rehfeld
Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark
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Finn Gustafsson
Finn Gustafsson
Department of Cardiology, Rigshospitalet, Copenhagen, Denmark
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Jens P Goetze
Jens P Goetze
Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark
Institute of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Institute of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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. The drug is composed of valsartan, an angiotensin-II receptor 1 blocker, and sacubitril, which inhibits the peptide-degrading enzyme neprilysin (neutral endopeptidase 24.11) ( 1 ). Neprilysin degrades a plethora of peptide hormones, including atrial
Hugo R Ramos
Hugo R Ramos
Department of Internal Medicine, Section of Metabolic Vascular Medicine, Division of Diabetes and Nutritional Sciences, Cardiovascular Endocrinology Laboratory, Faculty of Medicine, Hospital de Urgencias, National University of Córdoba, X5000 Córdoba, Argentina
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Andreas L Birkenfeld
Andreas L Birkenfeld
Department of Internal Medicine, Section of Metabolic Vascular Medicine, Division of Diabetes and Nutritional Sciences, Cardiovascular Endocrinology Laboratory, Faculty of Medicine, Hospital de Urgencias, National University of Córdoba, X5000 Córdoba, Argentina
Department of Internal Medicine, Section of Metabolic Vascular Medicine, Division of Diabetes and Nutritional Sciences, Cardiovascular Endocrinology Laboratory, Faculty of Medicine, Hospital de Urgencias, National University of Córdoba, X5000 Córdoba, Argentina
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Department of Internal Medicine, Section of Metabolic Vascular Medicine, Division of Diabetes and Nutritional Sciences, Cardiovascular Endocrinology Laboratory, Faculty of Medicine, Hospital de Urgencias, National University of Córdoba, X5000 Córdoba, Argentina
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Adolfo J de Bold
Adolfo J de Bold
Department of Internal Medicine, Section of Metabolic Vascular Medicine, Division of Diabetes and Nutritional Sciences, Cardiovascular Endocrinology Laboratory, Faculty of Medicine, Hospital de Urgencias, National University of Córdoba, X5000 Córdoba, Argentina
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strikingly low levels of plasma cNP (19, 20, 21, 22) due to multiple mechanisms that might include increased neprilysin-neutral endopeptidase activity resulting in increased degradation of circulating cNP and increased adipose tissue expression of the NP
Justyna Modrzynska
Justyna Modrzynska
Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Christine F Klein
Christine F Klein
Department of Cardiology, Herlev Gentofte Hospital, Herlev, Denmark
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Kasper Iversen
Kasper Iversen
Department of Clinical Medicine, Herlev Gentofte Hospital, Herlev, Denmark
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Henning Bundgaard
Henning Bundgaard
Department of Cardiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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Bolette Hartmann
Bolette Hartmann
Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Maike Mose
Maike Mose
Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark
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Nikolaj Rittig
Nikolaj Rittig
Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark
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Niels Møller
Niels Møller
Department of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark
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Jens J Holst
Jens J Holst
Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Nicolai J Wewer Albrechtsen
Nicolai J Wewer Albrechtsen
Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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patients ( 13 ), in mice following LPS injection ( 23 ), and in humans with burn lesions ( 24 ). Estimation of plasma GLP-1 in mice is troublesome due to the rapid degradation by neprilysin ( 25 , 26 ), and the assays employed in the current human study
Sara Ullsten
Sara Ullsten
Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden
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Sara Bohman
Sara Bohman
Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden
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Marie E Oskarsson
Marie E Oskarsson
Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden
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K Peter R Nilsson
K Peter R Nilsson
Department of Chemistry, Linköping University, Linköping, Sweden
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Gunilla T Westermark
Gunilla T Westermark
Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden
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Per-Ola Carlsson
Per-Ola Carlsson
Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden
Department of Medical Sciences, Uppsala University, Uppsala, Sweden
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Department of Medical Sciences, Uppsala University, Uppsala, Sweden
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microspheres ( n = 6, Fig. 4C , D and E ). There was neither any difference in the expression of insulin-degrading enzyme (IDE) ( n = 6, fold change 1.54 ± 0.51 in islets with microspheres) and neprilysin ( n = 4, fold change 1.22 ± 0.67 in islets with
Xianghe Chen
Xianghe Chen
College of Physical Education, Yangzhou University, Yangzhou, Jiangsu, China
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Xinyu Zeng
Xinyu Zeng
College of Physical Education, Yangzhou University, Yangzhou, Jiangsu, China
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Xiao Qiu
Xiao Qiu
College of Physical Education, Yangzhou University, Yangzhou, Jiangsu, China
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Chi Liu
Chi Liu
College of Physical Education, Yangzhou University, Yangzhou, Jiangsu, China
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Pengcheng Lu
Pengcheng Lu
College of Physical Education, Yangzhou University, Yangzhou, Jiangsu, China
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Ziming Shen
Ziming Shen
College of Physical Education, Yangzhou University, Yangzhou, Jiangsu, China
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Xiangxiang Zhou
Xiangxiang Zhou
College of Physical Education, Yangzhou University, Yangzhou, Jiangsu, China
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Kang Yang
Kang Yang
Department of Rehabilitation Medicine, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, Jiangsu, China
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Pressure Research 2021 46 219 – 228 . ( https://doi.org/10.1159/000514680 ) 27 Gutta S Grobe N Kumbaji M Osman H Saklayen M Li G & Elased KM . Increased urinary angiotensin converting enzyme 2 and neprilysin in patients with type 2
