Search Results

You are looking at 1 - 10 of 99 items for :

  • "mouse model" x
  • All content x
Clear All
Open access

K E Lines, R P Vas Nunes, M Frost, C J Yates, M Stevenson, and R V Thakker

in vivo studies several MEN1 mouse models have been generated and investigations of these have yielded important insights in NET cell proliferation and responses to treatments. For example, conventional heterozygous germline Men1 -knockout mouse

Open access

Ashley N Reeb, Andrea Ziegler, and Reigh-Yi Lin

.e.m . of two independent experiments with three parallels. Tumorigenesis analysis using an orthotopic mouse model of thyroid cancer in immunodeficient mice To explore whether the FTC cell lines could initiate tumors in vivo , we used an

Open access

Tatiana V Novoselova, Peter J King, Leonardo Guasti, Louise A Metherell, Adrian J L Clark, and Li F Chan

histopathology showing the absence of fasciculata or reticularis cells together with disorganisation of zona granulosa (ZG) cells ( 16 ). Recent data in mouse models show that PKA signalling overactivation drives the differentiation of a reticularis-like zone in

Open access

Bo Zhu, Yumei Chen, Fang Xu, Xiaolu Shen, Xuanyu Chen, Jieqiang Lv, and Songying Zhang

some PCOS patients and repair reproductive and metabolic disorders in PCOS models ( 12 , 13 , 14 ). Moreover, knockdown of AR can inhibit the metabolic and reproductive traits of PCOS in mouse model ( 15 ). ER stress promotes the accumulation of

Open access

Neil R Chappell, Beth Zhou, Amy K Schutt, William E Gibbons, and Chellakkan S Blesson

, 14 , 15 , 16 , 17 ). This group comprises 20–30% of the PCOS population and provides the opportunity to look at PCOS independent of obesity. Mouse models have long served as a useful platform to study PCOS, and several models have been described

Open access

Yali Cheng, Qiaoying Lv, Bingying Xie, Bingyi Yang, Weiwei Shan, Chengcheng Ning, Bing Li, Liying Xie, Chao Gu, Xuezhen Luo, Xiaojun Chen, and Qin Zhu

estrogen sensitivity are critical to endometrial tumorigenesis. To investigate the interaction between insulin resistance and estrogen in endometrial carcinogenesis, we established an ovariectomized C57BL/6 mouse model treated with subcutaneous

Open access

Serena Martinelli, Mario Maggi, and Elena Rapizzi

, RS1/2 cells have larger secretory granules and lack cytoplasmic vacuoles. Interestingly, RS0 cells grown in a serum-free medium form tumour cell spheroids spontaneously, which are able to grow in suspension. Mouse models For research purposes

Open access

Zhiwei Zhang, Hui Zhao, and Aixia Wang

effects of oleuropein in alleviating symptoms of GDM is warranted. In this study, we aimed to study the efficacy of oleuropein in treating GDM in a genetically modified mouse model of GDM. GDM symptoms, including increased blood glucose levels, body

Open access

Emmanuelle Noirrit, Mélissa Buscato, Marion Dupuis, Bernard Payrastre, Coralie Fontaine, Jean-François Arnal, and Marie-Cécile Valera

indicate that, after a chronic CE + BZA treatment, mouse models are protected from in vivo induced thrombosis without significant functional alterations to coagulation factor levels. Concerning the question of the thrombotic risk of TSEC, only

Open access

Yusaku Mori, Hiroyuki Shimizu, Hideki Kushima, Tomomi Saito, Munenori Hiromura, Michishige Terasaki, Masakazu Koshibu, Hirokazu Ohtaki, and Tsutomu Hirano

the vasoprotective and vasopressor effects of nesfatin-1 at different doses in mouse models of peripheral arterial remodeling. Additionally, we sought to clarify the underlying mechanisms in cultured human vascular endothelial cells (VECs) and vascular