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Dongyan Han Department of Pathology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, China

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Min Ding Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

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Rongli Xie Department of General Surgery, RuiJin Hospital Lu Wan Branch, Shanghai Jiaotong University School of Medicine, Shanghai, China

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Zhengshi Wang Thyroid Center, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, China
Shanghai Center of Thyroid Diseases, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, China

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Guohui Xiao Department of General Surgery, Pancreatic Disease Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

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Xiaohong Wang Shanghai Rigen Biotechnology Co., Ltd. Shanghai, China

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Lei Dong Department of Pathology, Shanghai Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

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Zhiqiang Yin Thyroid Center, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, China
Shanghai Center of Thyroid Diseases, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, China

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Jian Fei Department of General Surgery, Pancreatic Disease Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Research Institute of Pancreatic Diseases, Shanghai Jiao Tong University School of Medicine, Shanghai, China
State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Shanghai Jiao Tong University, Shanghai, China
Institute of Translational Medicine, Shanghai Jiao Tong University, Shanghai, China

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between cytological examination and molecular testing for thyroid nodules Next, whether the 18-gene test panel could predict malignancy was examined. There were 140 samples that could be used for calculating the diagnostic efficiency, which was

Article Type:
Research Article
Collections:
Thyroid
DOI:
https://doi.org/10.1530/EC-23-0135
Volume/Issue:
Volume 12: Issue 8
Open access
Klaudia Zajkowska Endocrinology, Holycross Cancer Centre, Kielce, Poland

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Janusz Kopczyński Surgical Pathology, Holycross Cancer Centre, Kielce, Poland

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Stanisław Góźdź Faculty of Health Sciences, Jan Kochanowski University, Kielce, Poland

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Aldona Kowalska Endocrinology, Holycross Cancer Centre, Kielce, Poland
Faculty of Health Sciences, Jan Kochanowski University, Kielce, Poland

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tumour should be examined to exclude the presence of papillary structures. In addition, secondary criteria (molecular testing for BRAF V600E and other high-risk mutations and immunohistochemistry for BRAF V600E) were added that may be helpful but are

Article Type:
Review Article
DOI:
https://doi.org/10.1530/EC-19-0566
Volume/Issue:
Volume 9: Issue 3
Open access
Irfan Vardarli 5th Medical Department, Division of Endocrinology and Diabetes, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany

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Susanne Tan Department of Endocrinology, Diabetes and Metabolism, Clinical Chemistry – Division of Laboratory Research Endocrine Tumor Center at WTZ/Comprehensive Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany

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Rainer Görges Department of Nuclear Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany

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Bernhard K Krämer 5th Medical Department, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany

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Ken Herrmann Department of Nuclear Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany

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Christoph Brochhausen Institue of Pathology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany

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, there is a need to avoid unnecessary thyroid surgery. The guidelines recommend the use of molecular tests for further management of thyroid nodules with indeterminate cytology (ITN); however, for the choice of the suitable method and the interpretation

Article Type:
Research Article
Collections:
Thyroid
DOI:
https://doi.org/10.1530/EC-24-0170
Volume/Issue:
Volume 13: Issue 7
Open access
Elizabeth J de Koster Department of Radiology and Nuclear Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands

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Olga Husson Department of Psychosocial Research and Epidemiology, Netherlands Cancer Institute, Amsterdam, The Netherlands
Division of Medical Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands
Division of Clinical Studies, Institute of Cancer Research, London, UK

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Eveline W C M van Dam Department of Internal Medicine, Division of Endocrinology, location VU University Medical Center, Amsterdam University Medical Centers, Amsterdam, The Netherlands

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G Sophie Mijnhout Department of Internal Medicine, Isala Hospital, Zwolle, The Netherlands

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Romana T Netea-Maier Department of Internal Medicine, Division of Endocrinology, Radboud University Medical Centre, Nijmegen, The Netherlands

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Wim J G Oyen Department of Radiology and Nuclear Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands
Department of Radiology and Nuclear Medicine, Rijnstate Hospital, Arnhem, The Netherlands
Department of Biomedical Sciences and Humanitas Clinical and Research Centre, Department of Nuclear Medicine, Humanitas University, Milan, Italy

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Marieke Snel Department of Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands

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Lioe-Fee de Geus-Oei Department of Radiology and Nuclear Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands
Department of Radiology, Section of Nuclear Medicine, Leiden University Medical Center, Leiden, The Netherlands
Biomedical Photonic Imaging Group, University of Twente, Enschede, The Netherlands

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Dennis Vriens Department of Radiology, Section of Nuclear Medicine, Leiden University Medical Center, Leiden, The Netherlands

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for the EfFECTS trial study group
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diagnostic surgery for approximately 75% benign nodules, a range of additional diagnostics is currently available, including various ultrasound classification systems, molecular testing, and 2-[ 18 F]fluoro-2-deoxy-D-glucose (FDG)-PET/CT ( 4 , 5 , 6 ). Our

Article Type:
Research Article
Collections:
Thyroid
DOI:
https://doi.org/10.1530/EC-22-0014
Volume/Issue:
Volume 11: Issue 8
Open access
Barbora Pekova Department of Molecular Endocrinology, Institute of Endocrinology, Prague 1, Czech Republic

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Sarka Dvorakova Department of Molecular Endocrinology, Institute of Endocrinology, Prague 1, Czech Republic

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Vlasta Sykorova Department of Molecular Endocrinology, Institute of Endocrinology, Prague 1, Czech Republic

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Gabriela Vacinova Department of Molecular Endocrinology, Institute of Endocrinology, Prague 1, Czech Republic

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Eliska Vaclavikova Department of Molecular Endocrinology, Institute of Endocrinology, Prague 1, Czech Republic

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Jitka Moravcova Department of Molecular Endocrinology, Institute of Endocrinology, Prague 1, Czech Republic

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Rami Katra Department of Ear, Nose and Throat, 2nd Faculty of Medicine, Charles University in Prague and Motol University Hospital, Prague 5, Czech Republic

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Petr Vlcek Department of Nuclear Medicine and Endocrinology, 2nd Faculty of Medicine, Charles University in Prague and Motol University Hospital, Prague 5, Czech Republic

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Pavla Sykorova Department of Nuclear Medicine and Endocrinology, 2nd Faculty of Medicine, Charles University in Prague and Motol University Hospital, Prague 5, Czech Republic

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Daniela Kodetova Department of Pathology and Molecular Medicine, 2nd Faculty of Medicine, Charles University in Prague and Motol University Hospital, Prague 5, Czech Republic

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Josef Vcelak Department of Molecular Endocrinology, Institute of Endocrinology, Prague 1, Czech Republic

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Bela Bendlova Department of Molecular Endocrinology, Institute of Endocrinology, Prague 1, Czech Republic

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variants should also be detected, which could be another trigger of thyroid cancer. The genetic molecular testing seems to be the benefit for pediatric patients for their diagnosis and prognosis. Hopefully, it will improve the quality of life of pediatric

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-19-0069
Volume/Issue:
Volume 8: Issue 6
Open access
Mahmoud Al-Masri Department of Surgery, King Hussein Cancer Center, Amman, Jordan

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Tawfiq Al-Shobaki Department of Surgery, King Hussein Cancer Center, Amman, Jordan

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Hani Al-Najjar Department of Surgery, King Hussein Cancer Center, Amman, Jordan

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Rafal Iskanderian Department of Surgery, King Hussein Cancer Center, Amman, Jordan

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Enas Younis Department of Internal Medicine, Endocrine, King Hussein Cancer Center, Amman, Jordan

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Niveen Abdallah Department of Cell Therapy & Applied Genomics, King Hussein Cancer Center, Amman, Jordan

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Abdelghani Tbakhi Department of Cell Therapy & Applied Genomics, King Hussein Cancer Center, Amman, Jordan

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Hussam Haddad Department of Pathology & Laboratory Medicine, King Hussein Cancer Center, Amman, Jordan

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Mohammad Al-Masri School of Medicine, University of Jordan, Amman, Jordan

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Zeinab Obeid Department of Surgery, King Hussein Cancer Center, Amman, Jordan

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Awad Jarrar Department of Surgery, King Hussein Cancer Center, Amman, Jordan

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Committee on Cancer (AJCC) staging system. Molecular testing for somatic genetic changes All the retrieved hematoxylin and eosin (H&E) stained sections for the cohort cases were reviewed separately by two experienced histopathologists at the

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-21-0410
Volume/Issue:
Volume 10: Issue 12
Open access
Danielle Christine Maria van der Kaay Erasmus University Medical Center, Department of Pediatrics, Subdivision of Endocrinology, Rotterdam, Netherlands

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Anne Rochtus Department of Pediatric Endocrinology, University Hospitals Leuven, Leuven, Belgium

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Gerhard Binder University Children’s Hospital, Pediatric Endocrinology, University of Tübingen, Tübingen, Germany

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Ingo Kurth Institute of Human Genetics, Medical Faculty, RWTH Aachen University, Aachen, Germany

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Dirk Prawitt Center for Paediatrics and Adolescent Medicine, University Medical Center, Mainz, Germany

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Irène Netchine Sorbonne Université, Centre de Recherche Saint-Antoine, INSERM, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France

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Gudmundur Johannsson Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
Department of Endocrinology at Sahlgrenska University Hospital, Gothenburg, Sweden

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Anita C S Hokken-Koelega Erasmus University Medical Center, Department of Pediatrics, Subdivision of Endocrinology, Rotterdam, Netherlands

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Miriam Elbracht Institute of Human Genetics, Medical Faculty, RWTH Aachen University, Aachen, Germany

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Thomas Eggermann Institute of Human Genetics, Medical Faculty, RWTH Aachen University, Aachen, Germany

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have exponentially increased our understanding of the underlying causes of short stature, but despite established clinical diagnostic and management recommendations, the decision on the molecular testing strategy in patients with growth disturbances can

Article Type:
Review Article
Collections:
Paediatric Endocrinology
DOI:
https://doi.org/10.1530/EC-22-0277
Volume/Issue:
Volume 11: Issue 11
Open access
Sara Ahmadi Division of Endocrinology, Thyroid Section, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA

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Iñigo Landa Division of Endocrinology, Thyroid Section, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA

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-specific mortality in a cohort of 69 RAS -driven DTCs ( 17 ). In addition, two recent side-by-side publications from the same group demonstrated the power of comprehensive molecular testing in predicting tumor recurrence and refining the current methods for risk

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Thyroid
DOI:
https://doi.org/10.1530/EC-23-0297
Volume/Issue:
Volume 13: Issue 2
Open access
Ayako Sato Department of Surgical Oncology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
Department of Tumor and Diagnostic Pathology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan

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Katsuya Matsuda Department of Tumor and Diagnostic Pathology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan

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Takahiro Motoyama Department of Tumor and Diagnostic Pathology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan

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Zhanna Mussazhanova Department of Tumor and Diagnostic Pathology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
Al-Farabi Kazakh National University, Almaty City, Republic of Kazakhstan

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Ryota Otsubo Department of Surgical Oncology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan

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Hisayoshi Kondo Biostatics Section, Division of Scientific Data Registry, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan

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Yuko Akazawa Department of Tumor and Diagnostic Pathology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan

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Miyoko Higuchi Department of Diagnostic Pathology and Cytology, Kuma Hospital, Kobe, Hyogo, Japan

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Ayana Suzuki Department of Diagnostic Pathology and Cytology, Kuma Hospital, Kobe, Hyogo, Japan

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Mitsuyoshi Hirokawa Department of Diagnostic Pathology and Cytology, Kuma Hospital, Kobe, Hyogo, Japan

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Akira Miyauchi Department of Diagnostic Pathology and Cytology, Kuma Hospital, Kobe, Hyogo, Japan

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Takeshi Nagayasu Department of Surgical Oncology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan

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Masahiro Nakashima Department of Tumor and Diagnostic Pathology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan

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1 expression were closely associated with high-grade malignancy. According to the 2017 Bethesda System for Reporting Thyroid Cytology, for category III or IV cases, molecular testing is usually recommended to obtain further diagnostic information

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-20-0630
Volume/Issue:
Volume 10: Issue 3
Open access
Natalie Rogowski-Lehmann Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, Munich, Germany

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Aikaterini Geroula Institut für Klinische Chemie und Laboratoriumsmedizin, Universitätsklinikum Carl Gustav Carus an der TU Dresden, Dresden, Germany

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Aleksander Prejbisz Department of Hypertension, Institute of Cardiology, Warsaw, Poland

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Henri J L M Timmers Section of Endocrinology, Department of Internal Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands

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Felix Megerle Medizinische Klinik und Poliklinik I des Universitätsklinikums Würzburg, Würzburg, Germany

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Mercedes Robledo Hereditary Endocrine Cancer Group, Human Cancer Genetics Programme, Spanish National Cancer Research Centre, Centro de Investigacion Biomedica en Red de Enfermedades Raras (CIBERER), Madrid, Spain

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Martin Fassnacht Medizinische Klinik und Poliklinik I des Universitätsklinikums Würzburg, Würzburg, Germany

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Stephanie M J Fliedner First Department of Medicine, University Medical Center Schleswig-Holstein, Lübeck, Germany

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Martin Reincke Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, Munich, Germany

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Anthony Stell Department of Computing and Information, University of Melbourne, Melbourne Australia

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Andrzej Januszewicz Department of Hypertension, Institute of Cardiology, Warsaw, Poland

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Jacques W M Lenders Section of Endocrinology, Department of Internal Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands
Medizinische Klinik III, Universitätsklinikum Carl Gustav Carus an der Technische Universität Dresden, Dresden, Germany

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Graeme Eisenhofer Institut für Klinische Chemie und Laboratoriumsmedizin, Universitätsklinikum Carl Gustav Carus an der TU Dresden, Dresden, Germany
Medizinische Klinik III, Universitätsklinikum Carl Gustav Carus an der Technische Universität Dresden, Dresden, Germany

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Felix Beuschlein Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, Munich, Germany
Klinik für Endokrinologie, Diabetologie und Klinische Ernährung, Universitätsspital Zürich, Zürich, Switzerland

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paraganglioma: molecular testing and personalized medicine . Current Opinion in Oncology 2016 28 5 – 10 . ( https://doi.org/10.1097/CCO.0000000000000249 ) 10.1097/CCO.0000000000000249 26599293 11 Favier J Amar L Gimenez-Roqueplo AP. Paraganglioma and

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-18-0318
Volume/Issue:
Volume 7: Issue 11
Open access